Comparison of Diagnostic Reliability of p63 and Smooth Muscle Actin in Salivary Gland Neoplasms.
Adenoid cystic carcinoma
Benign salivary neoplasm
Immunohistochemistry
Malignant salivary gland tumors
P63
Pleomorphic adenoma
SMA
Journal
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
ISSN: 2231-3796
Titre abrégé: Indian J Otolaryngol Head Neck Surg
Pays: India
ID NLM: 9422551
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
15
09
2020
accepted:
16
10
2020
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
2
12
2022
Statut:
ppublish
Résumé
Salivary gland neoplasms pose considerable diagnostic difficulty owing to their diverse histological features in individual lesions and the presence of a number of types and variants & similar histological features with other tumor entities. Myoepithelial and basal cells play a significant role in the pathogenesis of salivary gland neoplasm. p63 and smooth muscle actin are more reliable markers for identifying these cells and not studied much comparing their reliability in the diagnosis of salivary gland neoplasms. Hence, the aim of this study is to evaluate and compare the diagnostic reliability of immunohistochemical markers such as p63 and smooth muscle actin (SMA) in the diagnosis of various benign and malignant salivary gland neoplasms. The study comprises of 18 samples categorized into two groups: Group I comprised 9 cases, of which 4 cases were Pleomorphic adenoma, 2 cases were Myoepithelioma, 2 cases of Basal cell adenoma and 1 case was Warthin's tumor; and Group II consisted of 9cases, of which 3 was Mucoepidermoid carcinoma, 1 cases were Myoepithelial carcinoma and 5 cases were Adenoid cystic carcinoma. The selected cases were subjected to immunohistochemistry (IHC) procedure to assess the expression pattern of p63 and smooth muscle actin. The obtained data was analysed statistically by using Mann-Whitney test. In SMA, strong positivity for epithelial and connective tissue components of benign salivary neoplasm is about 22.2%respectively. In malignant salivary neoplasm, SMA was strongly positive for the epithelial and connective tissue component of about 77.7% and 88.8% cases respectively. The difference in the connective tissue components was found to be statistically significant (
Identifiants
pubmed: 36452668
doi: 10.1007/s12070-020-02237-6
pii: 2237
pmc: PMC9702114
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2520-2526Informations de copyright
© Association of Otolaryngologists of India 2020.
Références
Int J Surg Pathol. 2019 Jun;27(4):360-371
pubmed: 30482064
Am J Surg Pathol. 2009 Mar;33(3):409-16
pubmed: 18971778
Head Neck Pathol. 2013 Mar;7(1):64-8
pubmed: 23054955
Nature. 1999 Apr 22;398(6729):708-13
pubmed: 10227293
Cell Tissue Res. 2016 Aug;365(2):357-66
pubmed: 26979829
Arch Otolaryngol Head Neck Surg. 1990 Jun;116(6):692-6
pubmed: 1692711
Arch Pathol Lab Med. 2015 Jan;139(1):55-66
pubmed: 25549144
Trends Genet. 2002 Feb;18(2):90-5
pubmed: 11818141
Indian J Pathol Microbiol. 2018 Oct-Dec;61(4):479-484
pubmed: 30303133
Histopathology. 1994 Feb;24(2):187-91
pubmed: 8181816
J Oral Pathol. 1984 Aug;13(4):342-58
pubmed: 6432979
Head Neck Pathol. 2007 Dec;1(2):123-31
pubmed: 20614263
Acta Histochem Cytochem. 2012 Oct 31;45(5):269-82
pubmed: 23209336
Pathol Res Pract. 2009;205(12):838-42
pubmed: 19646823
Int J Surg Pathol. 2005 Jan;13(1):57-65
pubmed: 15735856
Br J Oral Maxillofac Surg. 2009 Dec;47(8):587-93
pubmed: 19409681
Oral Oncol. 1997 May;33(3):204-8
pubmed: 9307730
J Histochem Cytochem. 2003 Feb;51(2):133-9
pubmed: 12533521
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 May;97(5):613-9
pubmed: 15153875
Adv Anat Pathol. 2004 Mar;11(2):69-85
pubmed: 15090843
Prog Histochem Cytochem. 2003;38(4):343-426
pubmed: 14509196
J Oral Maxillofac Pathol. 2019 May-Aug;23(2):218-223
pubmed: 31516227
Histopathology. 2007 Jul;51(1):1-20
pubmed: 17539914
Head Neck. 2005 Aug;27(8):696-702
pubmed: 16021638
Nat Cell Biol. 2009 Dec;11(12):1451-7
pubmed: 19898465
J Oral Pathol Med. 2009 Sep;38(8):639-43
pubmed: 19473444