Small airways dysfunction in patients with systemic sclerosis and interstitial lung disease.
R5–R20
interstitial lung disease
phase III slopeN2SBW
pulmonary function tests
small airways dysfunction
systemic sclerosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
08
2022
accepted:
24
10
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
2
12
2022
Statut:
epublish
Résumé
A number of studies report small airways involvement in patients with systemic sclerosis (SSc). Furthermore, small airways dysfunction is increasingly recognized in patients with interstitial lung disease (ILD) of idiopathic or autoimmune etiology. The objectives of this study were to evaluate small airways function in SSc patients with ILD and explore the effect of treatment on small airways function by using conventional and contemporary pulmonary function tests (PFTs). This single-center, prospective, observational study included a total of 35 SSc patients, with and without ILD based on HRCT scan, evaluated by a special radiologist blindly. Clinical data were collected from all patients who were also assessed for HRCT findings of small airways disease. Small airways function was assessed by classic spirometry, measurement of diffusing capacity for carbon monoxide, body plethysmography, single breath nitrogen washout (N Phase III slope Phase III slope
Sections du résumé
Background
UNASSIGNED
A number of studies report small airways involvement in patients with systemic sclerosis (SSc). Furthermore, small airways dysfunction is increasingly recognized in patients with interstitial lung disease (ILD) of idiopathic or autoimmune etiology. The objectives of this study were to evaluate small airways function in SSc patients with ILD and explore the effect of treatment on small airways function by using conventional and contemporary pulmonary function tests (PFTs).
Methods
UNASSIGNED
This single-center, prospective, observational study included a total of 35 SSc patients, with and without ILD based on HRCT scan, evaluated by a special radiologist blindly. Clinical data were collected from all patients who were also assessed for HRCT findings of small airways disease. Small airways function was assessed by classic spirometry, measurement of diffusing capacity for carbon monoxide, body plethysmography, single breath nitrogen washout (N
Results
UNASSIGNED
Phase III slope
Conclusion
UNASSIGNED
Phase III slope
Identifiants
pubmed: 36452897
doi: 10.3389/fmed.2022.1016898
pmc: PMC9702077
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1016898Informations de copyright
Copyright © 2022 Panagopoulos, Goules, Georgakopoulou, Kallianos, Chatzinikita, Pezoulas, Malagari, Fotiadis, Vlachoyiannopoulos, Vassilakopoulos and Tzioufas.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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