Genetic variation in the dopamine system is associated with mixed-strategy decision-making in patients with Parkinson's disease.
Parkinson's disease
decision-making
dopamine
mixed-strategy
striatum
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
30 Nov 2022
30 Nov 2022
Historique:
revised:
16
11
2022
received:
15
07
2022
accepted:
25
11
2022
pubmed:
2
12
2022
medline:
2
12
2022
entrez:
1
12
2022
Statut:
aheadofprint
Résumé
Decision-making during mixed-strategy games requires flexibly adapting choice strategies in response to others' actions and dynamically tracking outcomes. Such decisions involve diverse cognitive processes, including reinforcement learning, which are affected by disruptions to the striatal dopamine system. We therefore investigated how genetic variation in dopamine function affected mixed-strategy decision-making in Parkinson's disease (PD), which involves striatal dopamine pathology. Sixty-six PD patients (ages 49-85, Hoehn and Yahr Stages 1-3) and 22 healthy controls (ages 54-75) competed in a mixed-strategy game where successful performance depended on minimizing choice biases (i.e., flexibly adapting choices trial by trial). Participants also completed a fixed-strategy task that was matched for sensory input, motor outputs and overall reward rate. Factor analyses were used to disentangle cognitive from motor aspects within both tasks. Using a within-subject, multi-centre design, patients were examined on and off dopaminergic therapy, and genetic variation was examined via a multilocus genetic profile score representing the additive effects of three single nucleotide polymorphisms (SNPs) that influence dopamine transmission: rs4680 (COMT Val
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ontario Brain Institute
Organisme : Parkinson's Canada Pilot Project Grant
Organisme : CIHR
ID : FDN-148418
Pays : Canada
Organisme : CIHR
ID : MOP-93667
Pays : Canada
Organisme : Ontario Neurodegenerative Disease Research Initiative
Organisme : Canada Research Chairs
Informations de copyright
© 2022 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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