Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems.
bone
gene-by-environment
quantitative genetics
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
09 02 2023
09 02 2023
Historique:
received:
02
07
2021
accepted:
07
11
2022
pubmed:
2
12
2022
medline:
14
2
2023
entrez:
1
12
2022
Statut:
ppublish
Résumé
Osteoporosis and bone fractures are a severe problem for the welfare of laying hens, with genetics and environment, such as housing system, each making substantial contributions to bone strength. In this work, we performed genetic analyses of bone strength, bone mineral density, and bone composition, as well as body weight, in 860 commercial crossbred laying hens from 2 different companies, kept in either furnished cages or floor pens. We compared bone traits between housing systems and crossbreds and performed a genome-wide association study of bone properties and body weight. As expected, the 2 housing systems produced a large difference in bone strength, with layers housed in floor pens having stronger bones. These differences were accompanied by differences in bone geometry, mineralization, and chemical composition. Genome scans either combining or independently analyzing the 2 housing systems revealed no genome-wide significant loci for bone breaking strength. We detected 3 loci for body weight that were shared between the housing systems on chromosomes 4, 6, and 27 (either genome-wide significant or suggestive) and these coincide with associations for bone length. In summary, we found substantial differences in bone strength, content, and composition between hens kept in floor pens and furnished cages that could be attributed to greater physical activity in pen housing. We found little evidence for large-effect loci for bone strength in commercial crossbred hens, consistent with a highly polygenic architecture for bone strength in the production environment. The lack of consistent genetic associations between housing systems in combination with the differences in bone phenotypes could be due to gene-by-environment interactions with housing system or a lack of power to detect shared associations for bone strength.
Identifiants
pubmed: 36453438
pii: 6855652
doi: 10.1093/g3journal/jkac302
pmc: PMC9911068
pii:
doi:
Banques de données
figshare
['10.6084/m9.figshare.14405894', '10.6084/m9.figshare.21340734']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20320000
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M028291/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Genetics Society of America.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare no conflict of interest.
Références
Poult Sci. 2008 May;87(5):828-37
pubmed: 18420972
J Struct Biol. 2018 Jan;201(1):36-45
pubmed: 29109023
Anim Genet. 2015 Aug;46(4):441-6
pubmed: 25908024
Methods Ecol Evol. 2016 Jul;7(7):792-799
pubmed: 27478587
Anim Genet. 2007 Feb;38(1):45-9
pubmed: 17257187
Bone Rep. 2016 Feb 26;5:43-50
pubmed: 28326346
Poult Sci. 2013 Aug;92(8):1972-80
pubmed: 23873543
Res Vet Sci. 1992 Jul;53(1):52-8
pubmed: 1410819
Br Poult Sci. 2001 May;42(2):260-5
pubmed: 11421336
Gigascience. 2020 Dec 30;9(12):
pubmed: 33377911
Cytokine Growth Factor Rev. 2005 Jun;16(3):319-27
pubmed: 15869900
J Anim Breed Genet. 2014 Jun;131(3):173-82
pubmed: 24628796
Poult Sci. 2002 Dec;81(12):1775-81
pubmed: 12512565
Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E909-21
pubmed: 23443924
PLoS One. 2015 Jan 30;10(1):e0116763
pubmed: 25635404
Nat Genet. 2018 Mar;50(3):362-367
pubmed: 29459679
J Anim Sci. 2018 Jun 29;96(7):2525-2535
pubmed: 29701819
J Bone Miner Res. 2007 Mar;22(3):375-84
pubmed: 17181401
Anim Genet. 2017 Jun;48(3):295-302
pubmed: 28124378
Nat Genet. 2008 May;40(5):575-83
pubmed: 18391952
Vet Rec. 2011 Oct 15;169(16):414
pubmed: 21862469
Genet Sel Evol. 2021 Feb 4;53(1):11
pubmed: 33541269
Br Poult Sci. 1994 Dec;35(5):651-62
pubmed: 7719730
Biom J. 2008 Jun;50(3):346-63
pubmed: 18481363
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Br Poult Sci. 2005 Oct;46(5):536-44
pubmed: 16359105
Nucleic Acids Res. 2016 Jan 4;44(D1):D827-33
pubmed: 26602686
Animals (Basel). 2021 Feb 26;11(3):
pubmed: 33652961
Bone. 2005 Dec;37(6):741-50
pubmed: 16183342
Genome Res. 2002 Apr;12(4):656-64
pubmed: 11932250
Br Poult Sci. 2000 Mar;41(1):33-40
pubmed: 10821520
Poult Sci. 2017 Aug 1;96(8):2518-2527
pubmed: 28431174
Br Poult Sci. 2022 Apr;63(2):115-124
pubmed: 34369224
PLoS One. 2012;7(7):e39929
pubmed: 22808074
Animals (Basel). 2021 Feb 27;11(3):
pubmed: 33673588
Vet J. 2010 Feb;183(2):153-60
pubmed: 19135394
Sci Rep. 2017 Apr 06;7:45317
pubmed: 28383518
Poult Sci. 2015 May;94(5):883-9
pubmed: 25784765
PLoS Genet. 2015 May 29;11(5):e1005250
pubmed: 26023928
Poult Sci. 1998 Oct;77(10):1492-6
pubmed: 9776056
J Dairy Sci. 2008 Nov;91(11):4414-23
pubmed: 18946147
Anim Genet. 2018 Oct;49(5):467-471
pubmed: 30058133
Int J Mol Sci. 2019 Jun 14;20(12):
pubmed: 31208008
Bioinformatics. 2012 Oct 1;28(19):2540-2
pubmed: 22843982
Br Poult Sci. 2006 Dec;47(6):742-55
pubmed: 17190683