Systolic and diastolic left ventricular function in children with primary hypertension: a systematic review and meta-analysis.
Journal
Journal of hypertension
ISSN: 1473-5598
Titre abrégé: J Hypertens
Pays: Netherlands
ID NLM: 8306882
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
3
12
2022
Statut:
ppublish
Résumé
Evaluation of left ventricular function provides early evidence of target-organ damage in children with primary hypertension. We performed a systematic review and meta-analysis of left ventricular systolic and diastolic function in children and adolescents with primary hypertension. Literature search was performed in PubMed database and out of 718 articles (published between 2000 and 2021) 22 studies providing comparison of left ventricular function parameters between children with primary hypertension and normotensive controls were selected. Overall, 3460 children (5-21 years) with primary hypertension were analyzed. Meta-analysis showed that hypertensive patients when compared with normotensives, had an increased heart rate (mean difference [MD] 5.59; 95% confidence interval [CI] 3.28, 7.89; 10 studies) and increased fractional shortening (MD 1.04; 95% CI 0.48, 1.60; 9 studies) but did not differ in ejection fraction (MD -0.03; 95% CI -1.07, 1.02; 12 studies). Stroke volume was higher in one out of three studies, whereas no differences in cardiac output were found in two studies with available data. Hypertensive children had also lower E/A values (MD -0.21; -0.33, -0.09; 14 studies), greater values of E/e' (MD 0.59; 0.36, 0.82; 8 studies) and greater global longitudinal stress (MD 2.50; 2.03, 2.96; 4 studies) when compared to those with normotension. Our results indicate that hypertensive children and adolescents present with signs of hyperkinetic function of the left ventricle, demonstrate evidence of increased left ventricular strain and impaired diastolic function compared to normotensive controls.
Identifiants
pubmed: 36453653
doi: 10.1097/HJH.0000000000003298
pii: 00004872-202301000-00006
doi:
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-62Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Références
Meng L, Hou D, Zhao X, Hu Y, Liang Y, Liu J, et al. Cardiovascular target organ damage could have been detected in sustained pediatric hypertension. Blood Press 2015; 24:284–292.
Litwin M, Niemirska A, Śladowska-Kozlowska J, Wierzbicka A, Janas R, Wawer ZT, et al. Regression of target organ damage in children and adolescents with primary hypertension. Pediatr Nephrol 2010; 25:2489–2499.
Liu W, Hou C, Hou M, Xu Q-Q, Wang H, Gu P-P, et al. Ultrasonography to detect cardiovascular damage in children with essential hypertension. Cardiovasc Ultrasound 2021; 19:26.
Litwin M, Niemirska A, Śladowska J, Antoniewicz J, Daszkowska J, Wierzbicka A, et al. Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension. Pediatr Nephrol 2006; 21:811–819.
Urbina EM, Lande MB, Hooper SR, Daniels SR. Target organ abnormalities in pediatric hypertension. J Pediatr 2018; 202:14–22.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 2021; 10:89.
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114:555–576.
Lurbe E, Cifkova R, Cruickshank JK, Dillon MJ, Ferreira I, Invitti C, et al. Manejo de la hipertensión arterial en niños y adolescentes: recomendaciones de la Sociedad Europea de Hipertensión. An Pediatría 2010; 73:e1–e51. e28.
Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 2016; 34:1887–1920.
Leung DH, Squires JE, Jhaveri R, Kerkar N, Lin C-H, Mohan P, et al. Hepatitis C in 2020: a North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper. J Pediatr Gastroenterol Nutr 2020; 71:407–417.
Flynn JT, Daniels SR, Hayman LL, Maahs DM, McCrindle BW, Mitsnefes M, et al. Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension 2014; 63:1116–1135.
Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, et al. Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 2017; 140:e20171904.
Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. National high blood pressure education program working group on hypertension control in children and adolescents. Pediatrics 1996; 98:649–658.
Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, et al. Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research. Hypertension 2008; 52:433–451.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003; 42:1206–1252.
Cheang MH, Kowalik GT, Quail MA, Steeden JA, Hothi D, Tullus K, et al. The cardiovascular phenotype of childhood hypertension: a cardiac magnetic resonance study. Pediatr Radiol 2019; 49:727–736.
Cilsal E, Koc AS. Renal resistive index significantly increased in hypertensive children and it is independently related to the pulse pressure and left ventricular mass index. Clin Exp Hypertens 2019; 41:607–614.
Gu H, Singh C, Li Y, Simpson J, Chowienczyk P, Sinha MD. Early ventricular contraction in children with primary hypertension relates to left ventricular mass. J Hypertens 2021; 39:711–717.
Hou M, Cao L, Ding Y, Chen Y, Wang B, Shen J, et al. Neutrophil to lymphocyte ratio is increased and associated with left ventricular diastolic function in newly diagnosed essential hypertension children. Front Pediatr 2021; 9:576005.
Kaplinski M, Griffis H, Liu F, Tinker C, Laney NC, Mendoza M, et al. Left ventricular measurements and strain in pediatric patients evaluated for systemic hypertension and the effect of adequate antihypertensive treatment. Pediatr Cardiol 2022; 43:155–163.
Abdul-Raheem JN, Binka E, Roem J, Turer CB, Urbina EM, Brady TM. Left ventricular diastolic dysfunction among youth with obesity and history of elevated blood pressure. J Pediatr 2021; 235:130–137.
Tran AH, Flynn JT, Becker RC, Daniels SR, Falkner BE, Ferguson M, et al. Subclinical systolic and diastolic dysfunction is evident in youth with elevated blood pressure. Hypertension 2020; 75:1551–1556.
Paris G, Gorla SR, Arenas-Morales AJ, Seeherunvong W, Swaminathan S. Comparison of echocardiographic changes in children with primary hypertension and hypertension due to mild to moderate chronic kidney disease. Pediatr Nephrol 2019; 34:487–494.
Zhang P, Li D, Su Y, Wang X, Sun J, Xu Y, et al. Assessment of myocardial strain in children with risk factors for atherosclerosis with use of 3D speckle tracking echocardiography. Echocardiography 2018; 35:487–493.
Gupta-Malhotra M, Hamzeh RK, Poffenbarger T, McNiece-Redwine K, Hashmi SS. Myocardial performance index in childhood onset essential hypertension and white coat hypertension. Am J Hypertens 2015; hpv123.
Zamojska J, Niewiadomska-Jarosik K, Wosiak A, Lipiec P, Stańczyk J. Myocardial dysfunction measured by tissue Doppler echocardiography in children with primary arterial hypertension. Kardiol Pol 2015; 73:194–200.
Pieruzzi F, Antolini L, Salerno FR, Giussani M, Brambilla P, Galbiati S, et al. The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children. J Hypertens 2015; 33:1182–1192.
Dušan P, Tamara I, Goran V, Gordana M-L, Amira P-A. Left ventricular mass and diastolic function in obese children and adolescents. Pediatr Nephrol 2015; 30:645–652.
Alp H, Karaarslan S, Eklioğlu BS, Atabek ME, Baysal T. The effect of hypertension and obesity on left ventricular geometry and cardiac functions in children and adolescents. J Hypertens 2014; 32:1283–1292.
Agu NC, McNiece Redwine K, Bell C, Garcia KM, Martin DS, Poffenbarger TS, et al. Detection of early diastolic alterations by Tissue Doppler Imaging in untreated childhood-onset essential hypertension. J Am Soc Hypertens 2014; 8:303–311.
Border WL, Kimball TR, Witt SA, Glascock BJ, Khoury P, Daniels SR. Diastolic filling abnormalities in children with essential hypertension. J Pediatr 2007; 150:503–509.
Floriańczyk T, Gołąbek-Dylewska M, Kucińska B, Werner B. Evaluation of left ventricular function in overweight children and teenagers with arterial hypertension and white coat hypertension. Cardiol J 2019; 26:343–349.
Wójtowicz J, Łempicka A, Łuczyński W, Szczepański W, Zomerfeld A, Semeran K, et al. Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension. Adv Clin Exp Med 2017; 26:1399–1404.
Navarini S, Bellsham-Revell H, Chubb H, Gu H, Sinha MD, Simpson JM. Myocardial deformation measured by 3-dimensional speckle tracking in children and adolescents with systemic arterial hypertension. Hypertension 2017; 70:1142–1147.
Morka A, Szydlowski L, Moric-Janiszewska E, Mazurek B, Markiewicz-Loskot G, Stec S. Left ventricular diastolic dysfunction assessed by conventional echocardiography and spectral tissue doppler imaging in adolescents with arterial hypertension. Medicine (Baltimore) 2016; 95:e2820.
Lee H, Kong Y-H, Kim K-H, Huh J, Kang I-S, Song J. Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension. Clin Hypertens 2015; 21:21.
Wikstrand J. Left ventricular function in early primary hypertension. Functional consequences of cardiovascular structural changes. Hypertension 1984; 6:III108–III116.
McEniery CM, Yasmin null, Wallace S, Maki-Petaja K, McDonnell B, Sharman JE, et al. Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults. Hypertension 2005; 46:221–226.
Obrycki Ł, Feber J, Derezinski T, Lewandowska W, Kułaga Z, Litwin M. Hemodynamic patterns and target organ damage in adolescents with ambulatory prehypertension. Hypertension 2020; 75:826–834.
Li Y, Gu H, Sinha MD, Chowienczyk P. Hemodynamic characterization of primary hypertension in children and adolescents. J Am Heart Assoc 2020; 9:e015097.
Julius S, Krause L, Schork NJ, Mejia AD, Jones KA, van de Ven C, et al. Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens 1991; 9:77–84.
Palatini P, Julius S. The role of cardiac autonomic function in hypertension and cardiovascular disease. Curr Hypertens Rep 2009; 11:199–205.
Julius S, Nesbitt S. Sympathetic overactivity in hypertension. A moving target. Am J Hypertens 1996; 9:113S–120S.
Julius S, Valentini M, Palatini P. Overweight and hypertension: a 2-way street? Hypertension 2000; 35:807–813.
Litwin M, Simonetti GD, Niemirska A, Ruzicka M, Wühl E, Schaefer F, et al. Altered cardiovascular rhythmicity in children with white coat and ambulatory hypertension. Pediatr Res 2010; 67:419–423.
Niemirska A, Litwin M, Feber J, Jurkiewicz E. Blood pressure rhythmicity and visceral fat in children with hypertension. Hypertension 2013; 62:782–788.
Lund-Johansen P. Central haemodynamics in essential hypertension at rest and during exercise: a 20-year follow-up study. J Hypertens Suppl 1989; 7:S52–S55.
Tadic M, Cuspidi C. Left ventricular strain and arterial hypertension: Is longitudinal strain ready for primetime? J Clin Hypertens 2020; 22:683–685.
Tadic M, Sala C, Carugo S, Mancia G, Grassi G, Cuspidi C. Myocardial strain in hypertension: a meta-analysis of two-dimensional speckle tracking echocardiographic studies. J Hypertens 2021; 39:2103–2112.
Biering-Sørensen T, Biering-Sørensen SR, Olsen FJ, Sengeløv M, Jørgensen PG, Mogelvang R, et al. Global longitudinal strain by echocardiography predicts long-term risk of cardiovascular morbidity and mortality in a low-risk general population: the Copenhagen City Heart Study. Circ Cardiovasc Imaging 2017; 10:e005521.
Dong Y, Ma J, Song Y, Dong B, Wang Z, Yang Z, et al. National blood pressure reference for Chinese han children and adolescents aged 7 to 17 years. Hypertension 2017; 70:897–906.
Wühl E, Witte K, Soergel M, Mehls O, Schaefer F. German Working Group on Pediatric Hypertension Distribution of 24-h ambulatory blood pressure in children: normalised reference values and role of body dimensions. Hypertens 2002; 20:1995–2200.
Kułaga Z, Litwin M, Grajda A, Gurzkowska B, Napieralska E, Kułaga K. OLAF Study Group. Distribution of blood pressure in school-aged children and adolescents reference population. Standardy Medyczne/Pediatria 2010; 7:853–864. [in Polish].