A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic).
Congenital defects
Disproporcional growth
Langobards
Skeletal dysplasia
Tooth cementum annulation (TCA)
Journal
International journal of paleopathology
ISSN: 1879-9825
Titre abrégé: Int J Paleopathol
Pays: Netherlands
ID NLM: 101562474
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
08
02
2022
revised:
19
10
2022
accepted:
13
11
2022
pubmed:
2
12
2022
medline:
25
2
2023
entrez:
1
12
2022
Statut:
ppublish
Résumé
To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530. Morphological and metric analyses. Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. The final diagnosis is limited by the lack of genetic analysis. Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.
Identifiants
pubmed: 36455429
pii: S1879-9817(22)00058-4
doi: 10.1016/j.ijpp.2022.11.003
pii:
doi:
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-40Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest.