A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic).

Congenital defects Disproporcional growth Langobards Skeletal dysplasia Tooth cementum annulation (TCA)

Journal

International journal of paleopathology
ISSN: 1879-9825
Titre abrégé: Int J Paleopathol
Pays: Netherlands
ID NLM: 101562474

Informations de publication

Date de publication:
03 2023
Historique:
received: 08 02 2022
revised: 19 10 2022
accepted: 13 11 2022
pubmed: 2 12 2022
medline: 25 2 2023
entrez: 1 12 2022
Statut: ppublish

Résumé

To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530. Morphological and metric analyses. Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. The final diagnosis is limited by the lack of genetic analysis. Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.

Identifiants

pubmed: 36455429
pii: S1879-9817(22)00058-4
doi: 10.1016/j.ijpp.2022.11.003
pii:
doi:

Types de publication

Case Reports Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

33-40

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest.

Auteurs

Lenka Vargová (L)

Research Group of Medical Anthropology and Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic. Electronic address: vargova@med.muni.cz.

Kateřina Vymazalová (K)

Research Group of Medical Anthropology and Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic. Electronic address: vymazalova@med.muni.cz.

Ivana Jarošová (I)

Freelancer in anthropology, Czech Republic. Electronic address: ivanajar@gmail.com.

Ivo Mařík (I)

Faculty of Health Care Studies, West Bohemia University, Pilsen Ambulant & Centre for Defects of Locomotor Apparatus, Olšanská 7, 130 00 Praha 3, Czech Republic. Electronic address: ambul_centrum@volny.cz.

Ladislava Horáčková (L)

Department of Kinesiology, Faculty of Sports Studies, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Electronic address: lhorac@fsps.muni.cz.

František Trampota (F)

Regional Museum in Mikulov, Zámek 1/4, 692 01 Mikulov, Czech Republic; Department of Archaeology and Museology, Faculty of Arts, Masaryk University, Arna Nováka 1, 602 00 Brno, Czech Republic; Institute of Archaeology of the Czech Academy of Sciences, Letenská 4, 118 01, Prague, Czech Republic. Electronic address: trampota@rmm.cz.

Katharina Rebay-Salisbury (K)

Austrian Archaeological Institute, Austrian Academy of Sciences, Hollandstraße 11-13, 1020 Vienna, Austria. Electronic address: katharina.rebay-salisbury@oeaw.ac.at.

Barbara Rendl (B)

Unit of Forensic Anthropology, Medical University of Vienna, Center for Forensic Medicine, Sensengasse 2, 1090 Vienna, Austria. Electronic address: barbara.rendl@gmail.com.

Fabian Kanz (F)

Unit of Forensic Anthropology, Medical University of Vienna, Center for Forensic Medicine, Sensengasse 2, 1090 Vienna, Austria. Electronic address: fabian.kanz@meduniwien.ac.at.

Denisa Zlámalová (D)

Department of Archaeology and Museology, Faculty of Arts, Masaryk University, Arne Nováka 1, 602 00 Brno, Czech Republic. Electronic address: 460688@mail.muni.cz.

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