Enhanced Mitochondrial Calcium Uptake Suppresses Atrial Fibrillation Associated With Metabolic Syndrome.

Mice Animals Atrial Fibrillation / etiology Calcium Metabolic Syndrome / complications Atrial Appendage Anti-Arrhythmia Agents Mice, Inbred C57BL
atrial arrhythmias calcium diabetic cardiomyopathy metabolism

Journal

Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365

Informations de publication

Date de publication:
06 12 2022
Historique:
received: 05 06 2022
revised: 12 09 2022
accepted: 20 09 2022
entrez: 1 12 2022
pubmed: 2 12 2022
medline: 6 12 2022
Statut: ppublish

Résumé

Patients with metabolic syndrome (MetS) have an increased risk of atrial fibrillation (AF). Impaired Ca The aim of this study was to determine the initial mechanisms related to AF susceptibility and mitochondrial dysfunction encountered in metabolic cardiomyopathy. A total of 161 mice and 34 patients were studied. Mitochondrial Ca Increased expression of the MICUs subunits of the MCUC (1.00 ± 0.33 AU vs 1.29 ± 0.23 AU; P = 0.034) was associated with impaired mitochondrial Ca Impaired MCUC activity and mitochondrial Ca

Sections du résumé

BACKGROUND
Patients with metabolic syndrome (MetS) have an increased risk of atrial fibrillation (AF). Impaired Ca
OBJECTIVES
The aim of this study was to determine the initial mechanisms related to AF susceptibility and mitochondrial dysfunction encountered in metabolic cardiomyopathy.
METHODS
A total of 161 mice and 34 patients were studied. Mitochondrial Ca
RESULTS
Increased expression of the MICUs subunits of the MCUC (1.00 ± 0.33 AU vs 1.29 ± 0.23 AU; P = 0.034) was associated with impaired mitochondrial Ca
CONCLUSIONS
Impaired MCUC activity and mitochondrial Ca

Identifiants

DOI: 10.1016/j.jacc.2022.09.041 PMID: 36456051
pubmed: 36456051
pii: S0735-1097(22)07040-1
doi: 10.1016/j.jacc.2022.09.041
pii:
doi:

Substances chimiques

Calcium SY7Q814VUP
Anti-Arrhythmia Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2205-2219

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Funding Support and Author Disclosures Dr Fauconnier was supported by the Fondation de France (No. 00056858/ No. 00121055). Drs Fauconnier and Montaigne were supported by ANR CALMOS (ANR-18-CE17-0003). Dr Panel was supported by the Fondation Lefoulon-Delalande. Drs Dr Panel and Lacampagne were supported by the Fondation pour la Recherche Médicale (No. DPC20171138967). Drs Montaigne, Butruille, Woitrain, and Decoin are supported by grants from Agence Nationale pour la Recherche (ANR-10-LABX-0046, ANR TOMIS-Leukocyte: ANR-CE14-0003-01), the Leducq Foundation LEAN Network 16CVD01. and the National Center for Precision Diabetic Medicine–PreciDIAB (ANR-18-IBHU-0001;20001891/NP0025517; 2019_ESR_11). All authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Auteurs

Lucile Fossier (L)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

Mathieu Panel (M)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

Laura Butruille (L)

University of Lille, Inserm, CHU Lille-Department of Cardiovascular Physiology, Institut Pasteur de Lille, Lille, France.

Sarah Colombani (S)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

Lan Azria (L)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

Eloise Woitrain (E)

University of Lille, Inserm, CHU Lille-Department of Cardiovascular Physiology, Institut Pasteur de Lille, Lille, France.

Raphael Decoin (R)

University of Lille, Inserm, CHU Lille-Department of Cardiovascular Physiology, Institut Pasteur de Lille, Lille, France.

Angelo G Torrente (AG)

IGF, Inserm, CNRS, University of Montpellier, Montpellier, France.

Jérôme Thireau (J)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

Alain Lacampagne (A)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France.

David Montaigne (D)

University of Lille, Inserm, CHU Lille-Department of Cardiovascular Physiology, Institut Pasteur de Lille, Lille, France.

Jérémy Fauconnier (J)

PhyMedExp, Inserm, CNRS, University of Montpellier, Montpellier, France. Electronic address: jeremy.fauconnier@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Eucaryotes › Animaux › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Atrium du coeur › Auricule de l'atrium › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antiarythmiques › Enhanced Mitochondrial Calcium Uptake...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Enhanced Mitochondrial Calcium Uptake...