Conserved structures of neural activity in sensorimotor cortex of freely moving rats allow cross-subject decoding.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 12 2022
02 12 2022
Historique:
received:
08
02
2021
accepted:
17
11
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
Our knowledge about neuronal activity in the sensorimotor cortex relies primarily on stereotyped movements that are strictly controlled in experimental settings. It remains unclear how results can be carried over to less constrained behavior like that of freely moving subjects. Toward this goal, we developed a self-paced behavioral paradigm that encouraged rats to engage in different movement types. We employed bilateral electrophysiological recordings across the entire sensorimotor cortex and simultaneous paw tracking. These techniques revealed behavioral coupling of neurons with lateralization and an anterior-posterior gradient from the premotor to the primary sensory cortex. The structure of population activity patterns was conserved across animals despite the severe under-sampling of the total number of neurons and variations in electrode positions across individuals. We demonstrated cross-subject and cross-session generalization in a decoding task through alignments of low-dimensional neural manifolds, providing evidence of a conserved neuronal code.
Identifiants
pubmed: 36456557
doi: 10.1038/s41467-022-35115-6
pii: 10.1038/s41467-022-35115-6
pmc: PMC9715555
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7420Informations de copyright
© 2022. The Author(s).
Références
PLoS Comput Biol. 2016 Nov 4;12(11):e1005175
pubmed: 27814352
Neuron. 2017 Jun 7;94(5):978-984
pubmed: 28595054
Science. 2008 Jul 4;321(5885):48-50
pubmed: 18599763
Nature. 2014 Aug 28;512(7515):423-6
pubmed: 25164754
Nat Neurosci. 2019 Oct;22(10):1677-1686
pubmed: 31551604
Neuron. 2018 Nov 21;100(4):964-976.e7
pubmed: 30344047
Nature. 2012 Jul 5;487(7405):51-6
pubmed: 22722855
Annu Rev Neurosci. 2014;37:435-56
pubmed: 25002277
Nat Commun. 2019 Oct 18;10(1):4745
pubmed: 31628322
J Neurosci. 2017 Nov 8;37(45):10904-10916
pubmed: 28972128
Elife. 2018 Aug 15;7:
pubmed: 30109848
Nat Neurosci. 2020 Feb;23(2):260-270
pubmed: 31907438
Front Syst Neurosci. 2008 Nov 24;2:4
pubmed: 19104670
Nature. 2021 Feb;590(7847):606-611
pubmed: 33361819
Neuron. 2017 Aug 2;95(3):683-696.e11
pubmed: 28735748
Neuron. 2020 Aug 19;107(4):745-758.e6
pubmed: 32516573
Neuron. 2018 Feb 21;97(4):953-966.e8
pubmed: 29398358
Annu Rev Neurosci. 2013 Jul 8;36:337-59
pubmed: 23725001
Nat Commun. 2021 Sep 10;12(1):5390
pubmed: 34508073
Nat Methods. 2018 Oct;15(10):805-815
pubmed: 30224673
Nat Commun. 2018 Oct 12;9(1):4233
pubmed: 30315158
Nat Neurosci. 2019 Feb;22(2):297-306
pubmed: 30643294
Neuron. 2011 Oct 20;72(2):404-16
pubmed: 22017997
Nat Commun. 2016 Oct 27;7:13239
pubmed: 27807345
Curr Biol. 2021 Oct 11;31(19):4293-4304.e5
pubmed: 34428470
Nat Rev Neurosci. 2009 Feb;10(2):113-25
pubmed: 19145235
Curr Biol. 2020 Jul 20;30(14):2665-2680.e8
pubmed: 32470366
Nat Neurosci. 2017 Jan;20(1):115-125
pubmed: 27918531
Nat Commun. 2019 Apr 5;10(1):1575
pubmed: 30952848
Nat Biomed Eng. 2020 Jul;4(7):672-685
pubmed: 32313100
Annu Rev Neurosci. 2020 Jul 8;43:249-275
pubmed: 32640928
J Neurosci. 2016 Oct 5;36(40):10440-10455
pubmed: 27707977
Science. 2018 Nov 2;362(6414):584-589
pubmed: 30385578
Nat Neurosci. 2014 Nov;17(11):1500-9
pubmed: 25151264
Curr Opin Neurobiol. 2015 Jun;32:148-55
pubmed: 25932978
Elife. 2019 Dec 10;8:
pubmed: 31820736
Nat Neurosci. 2014 Mar;17(3):440-8
pubmed: 24487233
IEEE Trans Neural Syst Rehabil Eng. 2017 Oct;25(10):1687-1696
pubmed: 28278476
Science. 2004 Mar 12;303(5664):1634-40
pubmed: 15016991
J Neurosci. 2018 Oct 31;38(44):9390-9401
pubmed: 30381431
Cereb Cortex. 2016 Jun;26(6):2919-2934
pubmed: 26980615
Brain Res. 1982 Jan 28;232(1):151-6
pubmed: 7055691