DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
08
12
2021
accepted:
11
11
2022
revised:
07
11
2022
pmc-release:
01
02
2024
pubmed:
2
12
2022
medline:
3
3
2023
entrez:
1
12
2022
Statut:
ppublish
Résumé
Hallmark pathological features of brain trauma are axonal degeneration and demyelination because myelin-producing oligodendrocytes (OLs) are particularly vulnerable to injury-induced death signals. To reveal mechanisms responsible for this OL loss, we examined a novel class of "death receptors" called dependence receptors (DepRs). DepRs initiate pro-death signals in the absence of their respective ligand(s), yet little is known about their role after injury. Here, we investigated whether the deleted in colorectal cancer (DCC) DepR contributes to OL loss after brain injury. We found that administration of its netrin-1 ligand is sufficient to block OL cell death. We also show that upon acute injury, DCC is upregulated while netrin-1 is downregulated in perilesional tissues. Moreover, after genetically silencing pro-death activity using DCC
Identifiants
pubmed: 36456775
doi: 10.1038/s41418-022-01091-z
pii: 10.1038/s41418-022-01091-z
pmc: PMC9950151
doi:
Substances chimiques
Dcc protein, mouse
0
DCC Receptor
0
Ligands
0
Nerve Growth Factors
0
Netrin-1
158651-98-0
Netrins
0
Receptors, Cell Surface
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-406Subventions
Organisme : NINDS NIH HHS
ID : R01 NS098740
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS120028
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.
Références
Front Cell Dev Biol. 2021 Mar 08;9:653101
pubmed: 33763430
Cell Death Dis. 2015 Oct 15;6:e1922
pubmed: 26469970
Cytokine Growth Factor Rev. 1999 Jun;10(2):119-30
pubmed: 10743503
Brain. 2013 Jan;136(Pt 1):28-42
pubmed: 23365092
Front Neurosci. 2019 Apr 26;13:409
pubmed: 31105519
J Neuroimmunol. 1999 Mar 1;95(1-2):115-25
pubmed: 10229121
J Neuropathol Exp Neurol. 2013 Dec;72(12):1106-25
pubmed: 24226267
Neuroscientist. 2019 Aug;25(4):334-343
pubmed: 30122106
Front Cell Neurosci. 2017 Dec 13;11:387
pubmed: 29321724
J Neurotrauma. 2002 May;19(5):503-57
pubmed: 12042091
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Cell. 1996 Oct 18;87(2):175-85
pubmed: 8861902
Cell Death Dis. 2018 Jan 8;9(1):7
pubmed: 29311672
Exp Neurol. 2013 Aug;246:35-43
pubmed: 22285252
J Clin Invest. 2017 Aug 1;127(8):3114-3125
pubmed: 28714867
Nature. 2020 Feb;578(7796):593-599
pubmed: 32051591
MMWR Morb Mortal Wkly Rep. 2019 Nov 22;68(46):1050-1056
pubmed: 31751321
J Neurosci. 2013 Oct 30;33(44):17278-89
pubmed: 24174661
Int J Mol Sci. 2021 May 02;22(9):
pubmed: 34063230
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14465-70
pubmed: 18796601
Sci Adv. 2021 Apr 16;7(16):
pubmed: 33863723
Science. 1998 Jun 5;280(5369):1610-3
pubmed: 9616125
Cell Rep. 2013 Jan 31;3(1):173-85
pubmed: 23291093
Psychosomatics. 2009 May-Jun;50(3):198-205
pubmed: 19567758
Mol Cell Neurosci. 2006 Apr;31(4):713-22
pubmed: 16483793
J Cereb Blood Flow Metab. 2000 Apr;20(4):669-77
pubmed: 10779011
Stem Cell Res. 2016 Nov;17(3):504-513
pubmed: 27771498
J Neurosci. 2001 Jun 1;21(11):3911-22
pubmed: 11356879
Neuron. 1997 Jan;18(1):59-70
pubmed: 9010205
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4128-33
pubmed: 16537496
Oncogene. 2007 Aug 16;26(38):5615-25
pubmed: 17334389
Brain Commun. 2020 Oct 18;2(2):fcaa175
pubmed: 33305261
Nat Med. 2014 Dec;20(12):1452-7
pubmed: 25419706
Acta Neuropathol. 2002 Jun;103(6):607-14
pubmed: 12012093
Neuron. 2014 Aug 20;83(4):839-849
pubmed: 25123307
Cell Death Differ. 2009 May;16(5):655-63
pubmed: 19148186
Nature. 1998 Oct 22;395(6704):801-4
pubmed: 9796814
Front Neurol. 2021 Sep 01;12:666430
pubmed: 34539542
Trends Pharmacol Sci. 2010 Dec;31(12):596-604
pubmed: 21035878
J Cereb Blood Flow Metab. 2007 Nov;27(11):1806-18
pubmed: 17406655
Lancet Neurol. 2019 Jan;18(1):56-87
pubmed: 30497965
Brain Inj. 2017;31(10):1270-1278
pubmed: 28686063
Biochim Biophys Acta. 2009 Feb;1793(2):231-8
pubmed: 18948148
Cell. 1994 Aug 12;78(3):425-35
pubmed: 8062385
Cell Mol Life Sci. 2004 Aug;61(15):1854-66
pubmed: 15289929
Neural Plast. 2017;2017:1582182
pubmed: 28491478
Cancer Res. 2020 Feb 15;80(4):747-756
pubmed: 31806640
J Neurosci. 2004 Dec 8;24(49):11010-6
pubmed: 15590916
Oncotarget. 2017 Apr 4;8(14):23750-23759
pubmed: 28423606
Nature. 2012 Apr 29;485(7399):517-21
pubmed: 22622581
Aging (Albany NY). 2020 Sep 9;12(17):17079-17098
pubmed: 32902412
J Alzheimers Dis. 2018;65(2):345-362
pubmed: 30040722
J Neurosci. 2012 Jan 4;32(1):356-71
pubmed: 22219296
Biol Cell. 2003 Oct;95(7):425-36
pubmed: 14597260
FASEB J. 2003 Jul;17(10):1367-9
pubmed: 12738800
Stem Cells. 2010 Jul;28(7):1231-42
pubmed: 20496368
J Neurotrauma. 2020 Nov 15;37(22):2381-2400
pubmed: 30907237
Handb Clin Neurol. 2021;183:235-260
pubmed: 34389120
Curr Opin Oncol. 2010 Jan;22(1):46-54
pubmed: 19934758
Oncogene. 2010 Apr 1;29(13):1865-82
pubmed: 20173780
EMBO Mol Med. 2016 Jan 31;8(2):96-104
pubmed: 26882243
Nature. 2011 Dec 11;482(7386):534-7
pubmed: 22158121
Neurobiol Dis. 2016 Oct;94:73-84
pubmed: 27317833
Nature. 2002 May 23;417(6887):443-7
pubmed: 11986622
J Neuropathol Exp Neurol. 2016 Jun;75(6):503-15
pubmed: 27105664
J Neurosci. 2008 Oct 22;28(43):11003-14
pubmed: 18945908
J Neurosurg. 2018 Apr 1;:1-18
pubmed: 29701556
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
J Neurosci. 2002 Dec 1;22(23):10346-56
pubmed: 12451134
Front Neurol. 2020 Sep 04;11:990
pubmed: 33013653
J Neurosci. 2018 Oct 10;38(41):8723-8736
pubmed: 30143572
Apoptosis. 2004 Jan;9(1):37-49
pubmed: 14739597
Brain Res. 2008 Sep 10;1229:210-7
pubmed: 18657520
Science. 1998 Aug 28;281(5381):1305-8
pubmed: 9721089
Brain Pathol. 2004 Apr;14(2):215-22
pubmed: 15193035
Curr Neuropharmacol. 2019;17(7):614-629
pubmed: 30207236
Int J Mol Sci. 2014 Jan 17;15(1):1216-36
pubmed: 24445258
J Neurosci. 2002 May 1;22(9):3504-11
pubmed: 11978827
Mol Med Rep. 2014 May;9(5):1761-6
pubmed: 24604122
Development. 2009 Feb;136(3):415-26
pubmed: 19141671
Eur J Neurosci. 2013 Jul;38(1):2153-65
pubmed: 23458840
Biomedicines. 2021 Jun 10;9(6):
pubmed: 34200905
Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84
pubmed: 19249984
J Neuropathol Exp Neurol. 2015 Mar;74(3):218-32
pubmed: 25668562
EMBO J. 2001 Jun 1;20(11):2715-22
pubmed: 11387206
Nature. 2012 Feb 22;482(7386):538-41
pubmed: 22358843
Dev Biol. 2000 Feb 15;218(2):259-74
pubmed: 10656768
J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92
pubmed: 15811950
J Neurosci Methods. 2016 Apr 1;263:57-67
pubmed: 26854397
Cell Death Dis. 2014 May 08;5:e1207
pubmed: 24810043
ACS Chem Neurosci. 2019 Mar 20;10(3):1595-1602
pubmed: 30421909
EMBO J. 2021 Feb 1;40(3):e105537
pubmed: 33351190