Acute ST-segment elevations following paclitaxel administration for uterine cervical cancer: a case report and literature review.
Cardiac ischemia
Chemotherapy
Gynecologic malignancy
Paclitaxel
Paclitaxel-induced myocardial infarction
ST elevation
Journal
Cardio-oncology (London, England)
ISSN: 2057-3804
Titre abrégé: Cardiooncology
Pays: England
ID NLM: 101689938
Informations de publication
Date de publication:
01 Dec 2022
01 Dec 2022
Historique:
received:
07
05
2022
accepted:
15
11
2022
entrez:
2
12
2022
pubmed:
3
12
2022
medline:
3
12
2022
Statut:
epublish
Résumé
Paclitaxel-induced cardiac ischemia is a rare but life-threatening complication. Although it may be difficult to distinguish from hypersensitivity or infusion reactions, it should not be overlooked. We herein report a rare case of ST-segment elevation following the administration of paclitaxel for uterine cervical cancer and review the literature regarding paclitaxel-induced cardiac ischemia.A 48-year-old woman with uterine cervical cancer with no cardiovascular risk factors was admitted to our hospital for concurrent chemoradiotherapy (CCRT) and planned to receive weekly paclitaxel and carboplatin for a total of 5 weeks. Just after the completion of the first cycle of paclitaxel infusion, she presented with diaphoresis and her consciousness level decreased. Electrocardiography showed ST elevation, suggesting acute myocardial infarction. Laboratory testing revealed troponin I positivity. Emergency coronary angiography (CAG) revealed a normal coronary artery, suggesting paclitaxel-induced vasospasm. After CAG, the patient was hemodynamically stable and was returned to the gynecologic unit two days after CAG. CCRT without paclitaxel was continued and the patient was uneventfully discharged from hospital.
Identifiants
pubmed: 36457122
doi: 10.1186/s40959-022-00148-9
pii: 10.1186/s40959-022-00148-9
pmc: PMC9714019
doi:
Types de publication
Letter
Langues
eng
Pagination
22Informations de copyright
© 2022. The Author(s).
Références
Gynecol Oncol. 2016 May;141(2):240-246
pubmed: 26883141
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1767-75
pubmed: 16002741
Semin Oncol. 1993 Aug;20(4 Suppl 3):1-15
pubmed: 8102012
Ann Pharmacother. 1996 Oct;30(10):1110-2
pubmed: 8893117
Curr Oncol Rep. 2018 Apr 30;20(7):52
pubmed: 29713898
Korean Circ J. 2009 Mar;39(3):124-7
pubmed: 19949600
Eur J Med Res. 2005 Nov 16;10(11):498-501
pubmed: 16354605
Can J Cardiol. 2003 Mar 15;19(3):300-2
pubmed: 12677287
Clin Cardiol. 2009 Jun;32(6):E94-6
pubmed: 19382279
J Clin Diagn Res. 2016 Oct;10(10):XD01-XD02
pubmed: 27891444
Clin Oncol (R Coll Radiol). 1997;9(2):124-6
pubmed: 9135899
Expert Opin Drug Metab Toxicol. 2021 Jul;17(7):785-801
pubmed: 34128748
J Assoc Physicians India. 2009 Apr;57:342-3
pubmed: 19702043
Cardiol Res. 2014 Aug;5(3-4):108-111
pubmed: 28348706
J Gynecol Oncol. 2017 Jan;28(1):e15
pubmed: 27958682
J Am Coll Cardiol. 2009 Dec 8;54(24):2321-9
pubmed: 19958969
J Clin Oncol. 2005 Oct 20;23(30):7685-96
pubmed: 16234530
J Cancer Res Ther. 2012 Jul-Sep;8(3):442-4
pubmed: 23174732