Intergenerational effects of maternal lifetime stressor exposure on offspring telomere length in Black and White women.
Cellular aging
Chronic stress
Intergenerational stress
Pregnancy
Race
STRAIN
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
medline:
4
10
2023
pubmed:
3
12
2022
entrez:
2
12
2022
Statut:
ppublish
Résumé
Although maternal stressor exposure has been associated with shorter telomere length (TL) in offspring, this literature is based largely on White samples. Furthermore, timing of maternal stressors has rarely been examined. Here, we examined how maternal stressors occurring during adolescence, pregnancy, and across the lifespan related to child TL in Black and White mothers. Mothers (112 Black; 110 White; Neither maternal adolescence nor lifespan stressors interacted with race in relation to child TL. In contrast, greater maternal pregnancy stressors were associated with shorter child TL, but this effect was present for children of White but not Black mothers. Moreover, this effect was significant for financial but not social pregnancy stressors. Race-stratified models revealed that greater financial pregnancy stressors predicted shorter telomeres in offspring of White, but not Black mothers. Race and maternal stressors interact and are related to biological aging across generations, but these effects are specific to certain races, stressors, and exposure time periods.
Sections du résumé
BACKGROUND
Although maternal stressor exposure has been associated with shorter telomere length (TL) in offspring, this literature is based largely on White samples. Furthermore, timing of maternal stressors has rarely been examined. Here, we examined how maternal stressors occurring during adolescence, pregnancy, and across the lifespan related to child TL in Black and White mothers.
METHOD
Mothers (112 Black; 110 White;
RESULTS
Neither maternal adolescence nor lifespan stressors interacted with race in relation to child TL. In contrast, greater maternal pregnancy stressors were associated with shorter child TL, but this effect was present for children of White but not Black mothers. Moreover, this effect was significant for financial but not social pregnancy stressors. Race-stratified models revealed that greater financial pregnancy stressors predicted shorter telomeres in offspring of White, but not Black mothers.
CONCLUSIONS
Race and maternal stressors interact and are related to biological aging across generations, but these effects are specific to certain races, stressors, and exposure time periods.
Identifiants
pubmed: 36457292
doi: 10.1017/S0033291722003397
pii: S0033291722003397
pmc: PMC10235210
mid: NIHMS1857560
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6171-6182Subventions
Organisme : NICHD NIH HHS
ID : R01 HD073568
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG062778
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL141878
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL145817
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059677
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG062778
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD051958
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG059677
Pays : United States
Références
Psychoneuroendocrinology. 2021 Jan;123:105043
pubmed: 33176222
Am J Public Health. 1992 Dec;82(12):1613-20
pubmed: 1456335
J Intern Med. 2007 May;261(5):412-7
pubmed: 17444880
J Gerontol A Biol Sci Med Sci. 2008 Sep;63(9):979-83
pubmed: 18840804
PLoS Med. 2006 Sep;3(9):e260
pubmed: 16968116
Am J Obstet Gynecol. 2016 Jul;215(1):94.e1-8
pubmed: 26829506
J Child Psychol Psychiatry. 2004 Feb;45(2):260-73
pubmed: 14982240
Arch Psychiatr Nurs. 2016 Feb;30(1):7-12
pubmed: 26804495
Sci Rep. 2020 Aug 19;10(1):13986
pubmed: 32814800
Child Psychiatry Hum Dev. 2019 Apr;50(2):278-290
pubmed: 30132095
BMJ. 2014 Jul 08;349:g4227
pubmed: 25006006
Qual Health Res. 2010 May;20(5):668-83
pubmed: 20154298
Stress. 2005 Mar;8(1):35-45
pubmed: 16019596
Psychol Bull. 2005 Sep;131(5):662-83
pubmed: 16187853
Brain Behav Immun. 2016 Nov;58:248-253
pubmed: 27470228
Child Maltreat. 2014 Mar 18;19(2):67-78
pubmed: 24642695
EBioMedicine. 2016 Sep;11:296-301
pubmed: 27566956
Am J Obstet Gynecol. 2004 Sep;191(3):691-9
pubmed: 15467527
Psychosom Med. 2016 Sep;78(7):776-87
pubmed: 27359174
Neuropsychopharmacology. 2017 Nov;42(12):2407-2413
pubmed: 28397798
Soc Sci Med. 2023 Jan;316:115070
pubmed: 35690497
Mol Biol Rep. 2020 Sep;47(9):7181-7188
pubmed: 32876842
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
J Adolesc Health. 2018 Nov;63(5):546-553
pubmed: 30348278
Psychoneuroendocrinology. 2018 Sep;95:74-85
pubmed: 29803183
J Clin Endocrinol Metab. 2015 Jan;100(1):267-73
pubmed: 25337925
Gene. 2019 Apr 30;694:97-101
pubmed: 30738962
Front Aging Neurosci. 2017 Dec 06;9:397
pubmed: 29270121
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5944-9
pubmed: 24711381
J Trauma Stress. 2003 Aug;16(4):399-409
pubmed: 12895023
Biol Lett. 2015 Nov;11(11):
pubmed: 26538535
J Psychiatr Res. 2017 Sep;92:47-54
pubmed: 28407508
Issues Ment Health Nurs. 2019 Aug;40(8):672-681
pubmed: 31081707
Exp Gerontol. 2014 Mar;51:15-27
pubmed: 24365661
Aging Cell. 2007 Oct;6(5):639-47
pubmed: 17874998
Psychoneuroendocrinology. 2019 Jun;104:210-218
pubmed: 30884304
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E513-8
pubmed: 21813766
Am J Psychiatry. 2020 Jan 1;177(1):47-57
pubmed: 31509004
Hum Nat. 2010 Mar 10;21(1):19-38
pubmed: 20436780
Ann Epidemiol. 2019 May;33:1-18.e3
pubmed: 30987864
Dev Psychobiol. 2014 Jan;56(1):117-25
pubmed: 23143986
Nat Hum Behav. 2020 Aug;4(8):811-818
pubmed: 32424258
Eur J Hum Genet. 2013 Oct;21(10):1163-8
pubmed: 23321625
Psychosom Med. 2011 Jan;73(1):16-22
pubmed: 21148804
Sci Rep. 2017 Feb 10;7:42160
pubmed: 28186106
Am J Obstet Gynecol. 2013 Feb;208(2):134.e1-7
pubmed: 23200710
Pediatrics. 2016 Apr;137(4):
pubmed: 26969272
Nicotine Tob Res. 2017 Nov 01;19(11):1292-1299
pubmed: 27811157
SSM Popul Health. 2021 Apr 16;14:100798
pubmed: 33997247
Annu Rev Psychol. 2007;58:201-25
pubmed: 16953796
J Gerontol B Psychol Sci Soc Sci. 2020 Feb 14;75(3):650-660
pubmed: 29878196
Genes (Basel). 2021 Jan 09;12(1):
pubmed: 33435482
J Behav Med. 2009 Feb;32(1):20-47
pubmed: 19030981
Brain Behav Immun. 2019 Aug;80:419-426
pubmed: 30974172
J Cell Physiol. 2014 Oct;229(10):1323-9
pubmed: 24374808
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):
pubmed: 29335381
J Pers Disord. 1997 Spring;11(1):19-33
pubmed: 9113820
Psychoneuroendocrinology. 2020 Nov;121:104841
pubmed: 32927181
J Aging Health. 2017 Dec;29(8):1350-1366
pubmed: 27469599
Mutat Res. 2012 Feb 1;730(1-2):85-9
pubmed: 21878343
Science. 2015 Dec 4;350(6265):1193-8
pubmed: 26785477
SSM Popul Health. 2021 Nov 20;16:100977
pubmed: 34869821
Atherosclerosis. 2012 Feb;220(2):506-12
pubmed: 22178426
Am J Psychiatry. 2021 Feb 1;178(2):183-192
pubmed: 32911996
Dev Psychobiol. 2018 Nov;60(7):753-764
pubmed: 30144041
Du Bois Rev. 2011 Spring;8(1):95-113
pubmed: 29887911
Ann N Y Acad Sci. 2019 Dec;1457(1):104-127
pubmed: 31403707
Rejuvenation Res. 2016 Dec;19(6):478-484
pubmed: 26950204
Psychoneuroendocrinology. 2019 Apr;102:225-235
pubmed: 30590340
Aging Cell. 2008 Aug;7(4):448-50
pubmed: 18462275
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6335-E6342
pubmed: 27698131
J Health Soc Behav. 2021 Jun;62(2):136-151
pubmed: 34100655
Psychosom Med. 2018 Jan;80(1):17-27
pubmed: 29016550
PLoS One. 2011;6(6):e20466
pubmed: 21695195
Am J Psychiatry. 2020 Jan 1;177(1):7-9
pubmed: 31892296
Biochem Biophys Res Commun. 2004 Apr 2;316(2):528-32
pubmed: 15020249
Psychol Med. 2004 Oct;34(7):1319-30
pubmed: 15697058
Annu Rev Clin Psychol. 2018 May 7;14:371-397
pubmed: 29494257