Assessment of the post-SARS-CoV-2 vaccination response depending on the epidemiological status, demographic parameters and levels of selected cytokines in medical personnel.

COVID 19 IgG S1 SARS-CoV 2 interferon-γ interleukin-8 transforming growth factor-β vaccination

Journal

Postepy dermatologii i alergologii
ISSN: 1642-395X
Titre abrégé: Postepy Dermatol Alergol
Pays: Poland
ID NLM: 101168357

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 20 07 2021
accepted: 22 09 2021
entrez: 2 12 2022
pubmed: 3 12 2022
medline: 3 12 2022
Statut: ppublish

Résumé

SARS-CoV-2 is responsible for causing the COVID-19 disease, which affected 174 million people worldwide. After vaccines were launched, the focus was on their effectiveness and the degree of their safety. The authors try to find factors that may affect the response to vaccination. The study was conducted in 47 adults (39 women and 8 men; age: 47.3 ±11.2). Participants were vaccinated with two doses of the Comirnaty mRNA vaccine. Each patient had a medical history taken and the concentration of specific sIgG antibodies against S1 protein and SARS-CoV-2 N protein, as well as of selected cytokines (IL-8, TGF-β, IFN-γ) was determined before and 3 weeks after the first and second dose of the vaccine. There were 18 convalescents among the respondents. A statistically significant increase in the concentration of specific sIgG S1 in subsequent determinations was observed. Higher levels of sIgG S1 were found after the first dose of the vaccine in COVID-19 convalescents. There was no statistically significant influence of age, body mass index and sex on the increase in the concentration of antibodies and the concentration of the determined cytokines. It was shown that the higher the initial TGF-β concentration, the greater the increase in sIgG S1 after administration of the vaccine. Vaccination did not increase the levels of IL-8, IFN-β and TGF-γ. A higher concentration of serum TGF-β before vaccination correlated with the higher concentration of sIgG S1 antibodies after the first dose of the vaccine.

Identifiants

pubmed: 36457677
doi: 10.5114/ada.2022.120884
pii: 48123
pmc: PMC9704466
doi:

Types de publication

Journal Article

Langues

eng

Pagination

913-922

Informations de copyright

Copyright: © 2022 Termedia Sp. z o. o.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Zbigniew Bartuzi (Z)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Tomasz Rosada (T)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Natalia Ukleja-Sokołowska (N)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Katarzyna Napiórkowska-Baran (K)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Kinga Lis (K)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Magdalena Żbikowska-Gotz (M)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Wojciech Kowalczyk (W)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Ewa Szynkiewicz (E)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Ewa Alska (E)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Łukasz Cała (Ł)

Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Classifications MeSH