Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.
IL-33
atopic dermatitis
polymorphism
Journal
Postepy dermatologii i alergologii
ISSN: 1642-395X
Titre abrégé: Postepy Dermatol Alergol
Pays: Poland
ID NLM: 101168357
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
15
10
2021
accepted:
06
12
2021
entrez:
2
12
2022
pubmed:
3
12
2022
medline:
3
12
2022
Statut:
ppublish
Résumé
Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD). To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD. The study group consisted of 191 patients with AD and 168 controls. The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.
Identifiants
pubmed: 36457695
doi: 10.5114/ada.2022.113130
pii: 46315
pmc: PMC9704459
doi:
Types de publication
Journal Article
Langues
eng
Pagination
959-964Informations de copyright
Copyright: © 2022 Termedia Sp. z o. o.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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