Amyloid precursor protein and mitochondria.
Alzheimer's disease
Amyloid precursor protein
Bioenergetics
Mitochondria
γ-secretase
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
22
09
2022
revised:
28
10
2022
accepted:
31
10
2022
pmc-release:
01
02
2024
pubmed:
4
12
2022
medline:
18
1
2023
entrez:
3
12
2022
Statut:
ppublish
Résumé
Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD. Mitochondrial dysfunction is observed in AD subjects within the brain and systemically. APP and γ-secretase are localized to mitochondria. APP can be processed within mitochondria and its localization to mitochondria affects function. Here we discuss the evidence showing APP and γ-secretase localize to mitochondria. We also discuss the implications for the function of APP and its cleavage products in regulating mitochondrial function.
Identifiants
pubmed: 36462447
pii: S0959-4388(22)00145-3
doi: 10.1016/j.conb.2022.102651
pmc: PMC9845182
mid: NIHMS1847985
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Amyloid Precursor Protein Secretases
EC 3.4.-
APP protein, human
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102651Subventions
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072973
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG056600
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflicts.
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