Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap.

Alzheimer's Disease Multiparametric quantitative imaging biomarker (mp-QIB) Multivariate biomarker QIBA Technical performance

Journal

Academic radiology
ISSN: 1878-4046
Titre abrégé: Acad Radiol
Pays: United States
ID NLM: 9440159

Informations de publication

Date de publication:
02 2023
Historique:
received: 02 06 2022
revised: 24 10 2022
accepted: 29 10 2022
pmc-release: 01 02 2024
pubmed: 5 12 2022
medline: 11 1 2023
entrez: 4 12 2022
Statut: ppublish

Résumé

Multiparametric quantitative imaging biomarkers (QIBs) offer distinct advantages over single, univariate descriptors because they provide a more complete measure of complex, multidimensional biological systems. In disease, where structural and functional disturbances occur across a multitude of subsystems, multivariate QIBs are needed to measure the extent of system malfunction. This paper, the first Use Case in a series of articles on multiparameter imaging biomarkers, considers multiple QIBs as a multidimensional vector to represent all relevant disease constructs more completely. The approach proposed offers several advantages over QIBs as multiple endpoints and avoids combining them into a single composite that obscures the medical meaning of the individual measurements. We focus on establishing statistically rigorous methods to create a single, simultaneous measure from multiple QIBs that preserves the sensitivity of each univariate QIB while incorporating the correlation among QIBs. Details are provided for metrological methods to quantify the technical performance. Methods to reduce the set of QIBs, test the superiority of the mp-QIB model to any univariate QIB model, and design study strategies for generating precision and validity claims are also provided. QIBs of Alzheimer's Disease from the ADNI merge data set are used as a case study to illustrate the methods described.

Identifiants

pubmed: 36464548
pii: S1076-6332(22)00585-2
doi: 10.1016/j.acra.2022.10.026
pmc: PMC9825667
mid: NIHMS1847635
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

159-182

Subventions

Organisme : Intramural FDA HHS
ID : FD999999
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States

Informations de copyright

Copyright © 2022 The Association of University Radiologists. All rights reserved.

Références

Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Biometrika. 1948 May;35(Pts 1-2):58-79
pubmed: 18867413
Stat Methods Med Res. 2021 Jan;30(1):99-111
pubmed: 32726189
Stat Methods Med Res. 2015 Feb;24(1):9-26
pubmed: 24919826
Stat Methods Med Res. 1999 Mar;8(1):3-15
pubmed: 10347857
Acad Radiol. 2023 Feb;30(2):183-195
pubmed: 36202670
Stat Med. 2020 Feb 28;39(5):602-616
pubmed: 31858640
Med Phys. 2014 Apr;41(4):042303
pubmed: 24694153
Stat Med. 1999 Jun 15;18(11):1341-54
pubmed: 10399200
Stroke. 2003 Dec;34(12):2985-94
pubmed: 14615619
J Appl Clin Med Phys. 2021 Jan;22(1):299-307
pubmed: 33369002
Arch Dermatol. 2002 Jan;138(1):42-8
pubmed: 11790166
Sci Immunol. 2019 Oct 18;4(40):
pubmed: 31628161
Leuk Lymphoma. 2017 Oct;58(10):2298-2303
pubmed: 28264597
AJR Am J Roentgenol. 2009 Jul;193(1):14-27
pubmed: 19542391
JACC Cardiovasc Imaging. 2018 Mar;11(3):400-408
pubmed: 28734926
Stat Methods Med Res. 2015 Feb;24(1):141-74
pubmed: 24872353
Radiology. 2015 Dec;277(3):813-25
pubmed: 26267831
Cardiovasc Diagn Ther. 2020 Aug;10(4):1032-1047
pubmed: 32968659
Stat Methods Med Res. 1992;1(1):69-95
pubmed: 1341653
Circ Heart Fail. 2012 Nov;5(6):742-9
pubmed: 23065036
Biometrics. 2022 May 9;:
pubmed: 35531926
Acad Radiol. 2023 Feb;30(2):215-229
pubmed: 36411153
Epidemiology. 2010 Jul;21 Suppl 4:S10-6
pubmed: 20526201
Clin Infect Dis. 2019 May 2;68(10):1691-1698
pubmed: 30321315
Neuroimage. 2022 Oct 15;260:119475
pubmed: 35840117
J Clin Oncol. 2014 Sep 20;32(27):3059-68
pubmed: 25113753
Neurology. 2010 Jan 19;74(3):201-9
pubmed: 20042704
J Rheumatol Suppl. 1994 Sep;41:86-9
pubmed: 7799394
Eur J Nucl Med Mol Imaging. 2022 Jun;49(7):2163-2173
pubmed: 35032179
Stat Med. 2001 Oct 15;20(19):2921-33
pubmed: 11568949
Stat Med. 2003 Oct 30;22(20):3133-50
pubmed: 14518019
Biometrics. 1984 Dec;40(4):1079-87
pubmed: 6534410
J Biopharm Stat. 2012;22(6):1220-43
pubmed: 23075019
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Eur Heart J. 2012 Jan;33(2):176-82
pubmed: 21900289
J Digit Imaging. 2014 Aug;27(4):496-506
pubmed: 24496552
Radiology. 2018 Feb;286(2):622-631
pubmed: 28858564
Multivariate Behav Res. 2012 Jan 1;47(3):448-462
pubmed: 23144511
J Clin Oncol. 2002 Sep 15;20(18):3826-40
pubmed: 12228202
Pharm Stat. 2007 Jul-Sep;6(3):171-80
pubmed: 17583553
Stat Med. 2022 Jan 30;41(2):356-373
pubmed: 34726280
Circ Res. 2020 Oct 23;127(10):1253-1260
pubmed: 32842915
J Clin Oncol. 2007 May 1;25(13):1753-9
pubmed: 17470865
Compr Psychoneuroendocrinol. 2021 Mar 29;7:100052
pubmed: 35757062
J Biopharm Stat. 2009;19(1):1-11; discussion 12-41
pubmed: 19127460
Radiol Cardiothorac Imaging. 2020 Feb 27;2(1):e190119
pubmed: 32715301
Neuroimage Clin. 2013 Jul 27;3:180-95
pubmed: 24179862
Biom J. 2016 Jan;58(1):104-32
pubmed: 25682941
Stat Med. 2010 Dec 30;29(30):3245-57
pubmed: 21170918
BMC Med Res Methodol. 2020 Jun 29;20(1):170
pubmed: 32600261
Respir Res. 2017 Jun 13;18(1):117
pubmed: 28610627
JAMA Dermatol. 2017 Feb 01;153(2):207-213
pubmed: 27892996
Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):836-44
pubmed: 26530752
Circulation. 2017 Jun 6;135(23):2299-2307
pubmed: 28584030
Ann Rheum Dis. 1999 Jun;58(6):342-9
pubmed: 10340958
J Clin Med. 2020 May 21;9(5):
pubmed: 32455558
Stat Methods Med Res. 2015 Feb;24(1):68-106
pubmed: 24919829
Sri Lankan J Appl Stat. 2014;5(4):227-246
pubmed: 27110215
Stat Med. 2012 Dec 30;31(30):4280-95
pubmed: 22825800
BMJ. 2010 Aug 18;341:c3920
pubmed: 20719825
J Neurovirol. 2017 Jun;23(3):422-429
pubmed: 28101804
Circ Cardiovasc Imaging. 2015 Nov;8(11):e004181
pubmed: 26546484
Clin Infect Dis. 2015 Sep 1;61(5):800-6
pubmed: 26113652
Biometrics. 1987 Sep;43(3):487-98
pubmed: 3663814
BMC Bioinformatics. 2014 Nov 05;15:346
pubmed: 25371041
J Clin Oncol. 2014 Sep 20;32(27):3048-58
pubmed: 25113771
Acad Radiol. 2017 Oct;24(10):1203-1215
pubmed: 28551396
Stat Methods Med Res. 2015 Feb;24(1):27-67
pubmed: 24919831
Stat Med. 2012 Nov 10;31(25):2973-84
pubmed: 22711298
Curr Osteoporos Rep. 2013 Jun;11(2):147-55
pubmed: 23504496
Br J Math Stat Psychol. 1984 May;37 ( Pt 1):62-83
pubmed: 6733054
Stat Med. 2007 Mar 15;26(6):1181-92
pubmed: 16927251
J Clin Oncol. 2007 Jul 20;25(21):3109-15
pubmed: 17577020
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):162-8
pubmed: 23323713
Brain. 2020 Dec 1;143(12):3816-3826
pubmed: 33253354
Clin Infect Dis. 2016 Mar 15;62(6):814-5
pubmed: 26658302
Radiology. 2010 Aug;256(2):348-64
pubmed: 20656830
BMC Evol Biol. 2012 Nov 21;12:222
pubmed: 23171139
Biometrics. 2011 Sep;67(3):1007-16
pubmed: 21306355
Endoscopy. 2021 Sep;53(9):893-901
pubmed: 33167043
J Pharm Biomed Anal. 2015 Nov 10;115:502-8
pubmed: 26299526
Alzheimers Dement (N Y). 2019 Jul 30;5:328-337
pubmed: 31388559
Phys Med. 2019 Apr;60:188-198
pubmed: 30910431
J Med Imaging (Bellingham). 2018 Jan;5(1):011018
pubmed: 29340286
World J Urol. 2017 May;35(5):695-701
pubmed: 27637908

Auteurs

David L Raunig (DL)

Department of Statistical and Quantitative Sciences, Data Science Institute, Takeda Pharmaceuticals, Cambridge, Massachusetts. Electronic address: draunig@snet.net.

Gene A Pennello (GA)

Center for Devices and Radiological Health, US Food and Drug Administration Division of Imaging, Diagnostic and Software Reliability, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland.

Jana G Delfino (JG)

Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland.

Andrew J Buckler (AJ)

Elucid Bioimaging, Inc., Boston, Massachusetts.

Timothy J Hall (TJ)

Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.

Alexander R Guimaraes (AR)

Department of Diagnostic Radiology, Oregon Health & Sciences University, Portland, Oregon.

Xiaofeng Wang (X)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, Ohio.

Erich P Huang (EP)

Biometric Research Program, Division of Cancer Treatment and Diagnosis - National Cancer Institute, National Institutes of Health, Bethesda, MD.

Huiman X Barnhart (HX)

Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina.

Nandita deSouza (N)

Division of Radiotherapy and Imaging, the Insitute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.

Nancy Obuchowski (N)

Department of Quantitative Health Sciences, Lerner Research Institute Cleveland Clinic Foundation, Cleveland, Ohio.

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