Probing the Biocompatibility and Immune Cell Association of Chiral, Water-Soluble, Bottlebrush Poly(2-oxazoline)s.

Mice Animals Water Tissue Distribution Oxazoles / chemistry Polyethylene Glycols Polymers / chemistry

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
09 01 2023
Historique:
pubmed: 6 12 2022
medline: 11 1 2023
entrez: 5 12 2022
Statut: ppublish

Résumé

Poly(2-oxazoline)s (POx) have received substantial attention as poly(ethylene glycol) (PEG) alternatives in the biomedical field due to their biocompatibility, high functionality, and ease of synthesis. While POx have demonstrated strong potential as biomaterial constituents, the larger family of poly(cyclic imino ether)s (PCIE) to which POx belongs remains widely underexplored. One highly interesting sub-class of PCIE is poly(2,4-disubstituted-2-oxazoline)s (PdOx), which bear an additional substituent on the backbone of the polymers' repeating units. This allows fine-tuning of the hydrophilic/hydrophobic balance and renders the PdOx chiral when enantiopure 2-oxazoline monomers are used. Herein, we synthesize new water-soluble (

Identifiants

DOI: 10.1021/acs.biomac.2c01105 PMID: 36464844
pubmed: 36464844
doi: 10.1021/acs.biomac.2c01105
doi:

Substances chimiques

poly(2-oxazoline) 0
Water 059QF0KO0R
Oxazoles 0
Polyethylene Glycols 3WJQ0SDW1A
Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

246-257

Auteurs

David Pizzi (D)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria3052, Australia.
ORCID: 0000-0003-3116-6946

James Humphries (J)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queesland4072, Australia.

Joshua P Morrow (JP)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria3052, Australia.

Ayaat M Mahmoud (AM)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria3052, Australia.

Nicholas L Fletcher (NL)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queesland4072, Australia.
ORCID: 0000-0002-2993-833X

Stefan E Sonderegger (SE)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queesland4072, Australia.
ORCID: 0000-0001-9873-0885

Craig A Bell (CA)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queesland4072, Australia.
ORCID: 0000-0002-8986-2795

Kristofer J Thurecht (KJ)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Queesland4072, Australia.
ORCID: 0000-0002-4100-3131

Kristian Kempe (K)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria3052, Australia.
Materials Science and Engineering, Monash University, Clayton, Victoria3800, Australia.
ORCID: 0000-0002-0136-9403

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Probing the Biocompatibility and Immune Cell...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Probing the Biocompatibility and Immune Cell...