Connexin43 in Musculoskeletal System: New Targets for Development and Disease Progression.
Connexin43
gap junction
hemichannel
liver
musculoskeletal system
osteoarthritis
osteoporosis
rheumatoid arthritis
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
01 Dec 2022
01 Dec 2022
Historique:
received:
09
03
2022
accepted:
21
04
2022
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
Connexin43, which is the most highly expressed connexin subtype in the musculoskeletal system, exists in a variety of bone cells, synovial tissue, and cartilage tissue. Connexin43 has been suggested to be a key regulator of bone homeostasis. Studies have shown aberrant Connexin43 expression in musculoskeletal disorders, such as osteoporosis, osteoarthritis, and rheumatoid arthritis. During cellular activities, Connexin43 can participate in the formation of functionally specific gap junctions and hemichannels and can exert independent cellular regulatory and signaling functions through special C-termini. The critical role of Connexin43 in physiological development and disease progression has been gradually revealed. In this article, the function of Connexin43 in musculoskeletal tissues is summarized, revealing the potential role of Connexin43 as a key target in the treatment of related bone and muscle disorders and the need for further discovery.
Identifiants
pubmed: 36465186
doi: 10.14336/AD.2022.0421
pii: ad-13-6-1715
pmc: PMC9662276
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1715-1732Informations de copyright
copyright: © 2022 An et al.
Déclaration de conflit d'intérêts
Competing interests The authors have declared that no competing interest exists.
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