Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis.

ectopic lymphoid-like structures (ELSs) follicular dendritic cells (FDCs) germinal center (GC) pericyte and perivascular platelet-derived growth factor (PDGF) rheumatoid arthritis synovial pathotypes tumor necrosis factor-α (TNF-α)

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2022
Historique:
received: 07 08 2022
accepted: 24 10 2022
entrez: 5 12 2022
pubmed: 6 12 2022
medline: 6 12 2022
Statut: epublish

Résumé

Follicular dendritic cells (FDCs) fundamentally contribute to the formation of synovial ectopic lymphoid-like structures in rheumatoid arthritis (RA) which is associated with poor clinical prognosis. Despite this critical role, regulation of FDC development in the RA synovium and its correlation with synovial pathotype differentiation remained largely unknown. Here, we demonstrate that CNA.42

Identifiants

DOI: 10.3389/fmed.2022.1013660 PMID: 36465908 PMC: PMC9709129
pubmed: 36465908
doi: 10.3389/fmed.2022.1013660
pmc: PMC9709129
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1013660

Subventions

Organisme : Medical Research Council
ID : G0800648
Pays : United Kingdom

Informations de copyright

Copyright © 2022 El Shikh, El Sayed, Aly, Prediletto, Hands, Fossati-Jimack, Bombardieri, Lewis and Pitzalis.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Mohey Eldin M El Shikh (MEM)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Riham El Sayed (R)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Nesreen Amer Ramadan Aly (NAR)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Edoardo Prediletto (E)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Rebecca Hands (R)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Liliane Fossati-Jimack (L)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Michele Bombardieri (M)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Myles J Lewis (MJ)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Costantino Pitzalis (C)

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Classifications MeSH