Regulation of T cell function by protein S-acylation.
DHHC enzymes
S-acylation
T cell receptor
T cell signaling
palmitoyl acyltransferases
palmitoylation
protein acyltransferases
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
09
2022
accepted:
02
11
2022
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of S-acylation sets this modification apart from other forms of protein lipidation and allows it to play a unique role in intracellular signal transduction. In recent years, a significant number of T cell proteins, including receptors, enzymes, ion channels, and adaptor proteins, were identified as S-acylated. It has been shown that S-acylation critically contributes to their function by regulating protein localization, stability and protein-protein interactions. Furthermore, it has been demonstrated that zDHHC protein acyltransferases, the family of enzymes mediating this modification, also play a prominent role in T cell activation and differentiation. In this review, we aim to highlight the diversity of proteins undergoing S-acylation in T cells, elucidate the mechanisms by which reversible lipidation can impact protein function, and introduce protein acyltransferases as a novel class of regulatory T cell proteins.
Identifiants
pubmed: 36467682
doi: 10.3389/fphys.2022.1040968
pii: 1040968
pmc: PMC9709458
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1040968Informations de copyright
Copyright © 2022 West, Boehning and Akimzhanov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Curr Pharm Des. 2021;27(18):2189-2198
pubmed: 33183190
Mol Cell Biol. 2008 Sep;28(17):5209-22
pubmed: 18591248
PLoS One. 2010 Nov 30;5(11):e15045
pubmed: 21152083
Nat Chem Biol. 2010 Jul;6(7):498-506
pubmed: 20559317
J Biol Chem. 1993 Apr 25;268(12):8669-74
pubmed: 8473310
Cell. 2008 Oct 3;135(1):110-22
pubmed: 18854159
Elife. 2015 Dec 23;4:e11306
pubmed: 26701913
Biochem Soc Trans. 2013 Feb 1;41(1):79-83
pubmed: 23356262
Trends Biochem Sci. 2018 Feb;43(2):108-123
pubmed: 29269020
Elife. 2017 Aug 15;6:
pubmed: 28826475
Nat Immunol. 2013 Jul;14(7):723-31
pubmed: 23666293
Front Immunol. 2020 Mar 12;11:348
pubmed: 32226427
EMBO J. 1995 Nov 15;14(22):5579-88
pubmed: 8521815
Science. 2005 Mar 18;307(5716):1746-52
pubmed: 15705808
Biochem Soc Trans. 2019 Feb 28;47(1):157-167
pubmed: 30559274
J Exp Med. 2002 Aug 5;196(3):293-301
pubmed: 12163558
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1177-83
pubmed: 16460687
Nature. 1990 Aug 23;346(6286):719-23
pubmed: 2201921
Biochem Soc Trans. 2015 Apr;43(2):193-8
pubmed: 25849916
Eur J Cell Biol. 2018 Jun;97(5):319-338
pubmed: 29602512
J Biol Chem. 1980 Nov 10;255(21):10021-4
pubmed: 7430112
J Cell Biol. 2000 Oct 16;151(2):199-208
pubmed: 11038169
J Leukoc Biol. 2013 Sep;94(3):521-9
pubmed: 23801652
Immunol Rev. 2009 Sep;231(1):59-87
pubmed: 19754890
EMBO J. 2011 May 4;30(9):1673-5
pubmed: 21540881
J Biol Chem. 2007 May 4;282(18):13884-94
pubmed: 17341584
Front Immunol. 2012 Sep 21;3:291
pubmed: 23055999
Immunity. 2019 Jan 15;50(1):212-224.e4
pubmed: 30650377
J Biol Chem. 2010 Feb 26;285(9):6063-70
pubmed: 20040600
J Biol Chem. 2011 Nov 11;286(45):39573-84
pubmed: 21926431
Mol Cell Biol. 1999 Oct;19(10):6775-87
pubmed: 10490616
Mol Membr Biol. 2009 Jan;26(1):93-103
pubmed: 19115146
Nat Commun. 2016 Sep 22;7:12823
pubmed: 27653213
J Immunol. 2001 Apr 15;166(8):4981-6
pubmed: 11290777
J Biol Chem. 1996 Jun 28;271(26):15831-6
pubmed: 8663305
Curr Biol. 2006 Oct 24;16(20):2073-9
pubmed: 16978865
Curr Opin Immunol. 2000 Jun;12(3):289-94
pubmed: 10781411
J Vis Exp. 2020 Apr 10;(158):
pubmed: 32338654
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4573-8
pubmed: 10781062
Oncogene. 2004 Oct 18;23(48):7918-27
pubmed: 15489910
J Immunol. 2004 May 15;172(10):5887-92
pubmed: 15128768
J Immunol. 2011 Feb 15;186(4):2127-37
pubmed: 21220695
J Biol Chem. 2008 Jun 20;283(25):17333-40
pubmed: 18430726
Annu Rev Immunol. 2009;27:591-619
pubmed: 19132916
J Cell Biol. 2002 May 27;157(5):865-72
pubmed: 12021258
J Biol Chem. 1993 May 25;268(15):11394-400
pubmed: 7684381
Curr Opin Immunol. 2004 Jun;16(3):264-70
pubmed: 15134773
Physiol Rev. 2015 Apr;95(2):341-76
pubmed: 25834228
EMBO J. 2007 Jan 10;26(1):209-20
pubmed: 17159908
Nature. 2006 May 11;441(7090):179-85
pubmed: 16582901
Cell Rep. 2016 Dec 6;17(10):2776-2788
pubmed: 27926878
Eur J Immunol. 2008 Jan;38(1):250-9
pubmed: 18085663
Trends Biochem Sci. 2011 May;36(5):245-53
pubmed: 21388813
Nat Immunol. 2006 Aug;7(8):803-9
pubmed: 16855606
Biochim Biophys Acta. 2006 Apr;1761(4):474-83
pubmed: 16647879
J Biol Chem. 2001 Aug 17;276(33):30987-94
pubmed: 11423543
J Biol Chem. 2006 Jul 28;281(30):20661-20665
pubmed: 16766533
J Immunol. 2010 Sep 15;185(6):3536-43
pubmed: 20713885
Arch Biochem Biophys. 2004 Jun 15;426(2):208-24
pubmed: 15158671
Genetics. 1976 Sep;84(1):59-65
pubmed: 791749
Cell Death Differ. 2012 Jan;19(1):42-50
pubmed: 21959933
Protein Eng Des Sel. 2008 Nov;21(11):639-44
pubmed: 18753194
J Biol Chem. 2021 Jan-Jun;296:100311
pubmed: 33482200
J Biol Chem. 1993 Aug 25;268(24):18243-8
pubmed: 8349700
Blood. 2000 May 15;95(10):3199-203
pubmed: 10807788
FASEB J. 2009 Aug;23(8):2605-15
pubmed: 19299482
J Immunol. 2002 Sep 15;169(6):2813-7
pubmed: 12218089
J Exp Med. 2001 Nov 19;194(10):1485-95
pubmed: 11714755
J Cell Sci. 2022 Mar 1;135(5):
pubmed: 34156466
J Biol Chem. 2006 Nov 24;281(47):35855-62
pubmed: 17020874
Cell Mol Life Sci. 2013 Aug;70(15):2637-56
pubmed: 23052215
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11876-80
pubmed: 26351666
Biotechniques. 2004 Feb;36(2):276-85
pubmed: 14989092
Mol Biol Cell. 2008 Jul;19(7):2802-17
pubmed: 18448669
Science. 2018 Jan 12;359(6372):
pubmed: 29326245
J Cell Biol. 2003 Jan 20;160(2):165-70
pubmed: 12527752
N Engl J Med. 2009 May 7;360(19):1971-80
pubmed: 19420366
Semin Cell Dev Biol. 2007 Oct;18(5):608-15
pubmed: 17890113
Commun Biol. 2020 Jul 10;3(1):368
pubmed: 32651440
J Biol Chem. 1994 Jun 17;269(24):16701-5
pubmed: 8206991
Cell Death Dis. 2010 Oct 21;1:e88
pubmed: 21368861
J Biol Chem. 2014 Dec 5;289(49):33850-61
pubmed: 25301946
Biochem J. 1998 Aug 1;333 ( Pt 3):615-9
pubmed: 9677320
J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):297-301
pubmed: 23856010
J Biol Chem. 1997 Dec 12;272(50):31362-8
pubmed: 9395466
Nat Immunol. 2008 Apr;9(4):432-43
pubmed: 18327260
J Immunol. 2000 Aug 15;165(4):2068-76
pubmed: 10925291
Exp Mol Med. 2020 May;52(5):750-761
pubmed: 32439954
J Immunol. 2003 Jan 15;170(2):913-21
pubmed: 12517957
Biophys J. 2006 Sep 1;91(5):1619-29
pubmed: 16751250
Mol Cell Biol. 2000 Mar;20(5):1759-71
pubmed: 10669752
Curr Biol. 2005 Jul 12;15(13):1235-41
pubmed: 16005298
J Immunol. 2002 Apr 15;168(8):4121-6
pubmed: 11937572
J Cell Sci. 2022 Mar 1;135(5):
pubmed: 34080635
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9357-62
pubmed: 16751269
Immunity. 2021 Jul 13;54(7):1561-1577.e7
pubmed: 34102100
Antioxidants (Basel). 2017 Dec 29;7(1):
pubmed: 29286308
Crit Rev Immunol. 2014;34(4):301-14
pubmed: 24941158
Immunity. 2006 May;24(5):513-22
pubmed: 16713970
Am J Clin Exp Immunol. 2012;1(2):147-153
pubmed: 23205323
Cell Death Differ. 2015 Apr;22(4):643-53
pubmed: 25301068
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1365-E1374
pubmed: 28167757
EMBO J. 1997 Aug 15;16(16):4983-98
pubmed: 9305640
Mol Biol Rep. 2020 Aug;47(8):6471-6478
pubmed: 32789573
Nat Rev Immunol. 2019 Mar;19(3):154-169
pubmed: 30622345
Immunol Rev. 2008 Feb;221:90-106
pubmed: 18275477
J Exp Med. 2000 May 1;191(9):1591-604
pubmed: 10790433
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2011-6
pubmed: 18250319
Nat Immunol. 2020 Mar;21(3):298-308
pubmed: 32066953
Sci Rep. 2017 Feb 20;7:42758
pubmed: 28218251
Front Mol Biosci. 2021 Apr 26;8:656440
pubmed: 33981723
J Biol Chem. 2002 Oct 25;277(43):41268-73
pubmed: 12193598
Antioxid Redox Signal. 2015 Oct 1;23(10):854-62
pubmed: 26058750
J Biol Chem. 1998 Jun 19;273(25):15830-7
pubmed: 9624183
Sci Rep. 2015 Jun 26;5:11598
pubmed: 26111759
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83
pubmed: 25368151
Adv Immunol. 2011;109:1-44
pubmed: 21569911
Fly (Austin). 2008 Jul-Aug;2(4):198-214
pubmed: 18719403
Nat Immunol. 2002 Oct;3(10):911-7
pubmed: 12244310
Mol Membr Biol. 2011 Oct-Nov;28(7-8):473-86
pubmed: 22034844
Nat Rev Immunol. 2011 Sep 09;11(10):672-84
pubmed: 21904389
Immunity. 1998 Aug;9(2):239-46
pubmed: 9729044
Nature. 2020 Oct;586(7829):434-439
pubmed: 33029007
Immunol Lett. 2004 Mar 29;92(1-2):43-9
pubmed: 15081526
Mol Cell Biol. 1995 Dec;15(12):6914-22
pubmed: 8524258
J Biol Chem. 2022 Sep;298(9):102303
pubmed: 35934052
Immunity. 2001 Nov;15(5):691-701
pubmed: 11728332
J Biol Chem. 1994 Feb 11;269(6):4571-6
pubmed: 8308028
Cell. 1990 Oct 5;63(1):133-9
pubmed: 2208277
J Biol Chem. 2012 Mar 2;287(10):7236-45
pubmed: 22247542
PLoS Genet. 2009 Nov;5(11):e1000748
pubmed: 19956733
J Neurosci. 2016 Jun 15;36(24):6431-44
pubmed: 27307232
Cell. 1979 Aug;17(4):813-9
pubmed: 226266
Nat Immunol. 2018 Jul;19(7):733-741
pubmed: 29915297
J Biol Chem. 1993 Oct 25;268(30):22566-74
pubmed: 7901201
EMBO J. 2007 Jan 10;26(1):221-31
pubmed: 17159907
Annu Rev Biophys. 2012;41:543-56
pubmed: 22404679
J Biol Chem. 1992 Jul 5;267(19):13593-7
pubmed: 1618861
Immunity. 2010 Jun 25;32(6):766-77
pubmed: 20541955
J Cell Biol. 2002 Oct 14;159(1):23-8
pubmed: 12370247
J Biol Chem. 1994 Sep 16;269(37):23212-9
pubmed: 7916016
J Cell Biol. 1997 Mar 10;136(5):1023-35
pubmed: 9060467
J Biol Chem. 2004 Jan 2;279(1):704-12
pubmed: 14570906
Nat Rev Immunol. 2013 Apr;13(4):257-69
pubmed: 23524462
Methods Mol Biol. 2019;2009:203-214
pubmed: 31152406
Elife. 2021 Dec 16;10:
pubmed: 34913437