Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis.
Takayasu Arteritis (TA)
bulk RNA sequencing
interleukin
single cell RNA sequencing (scRNA)
smooth muscle cell (SMC)
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
09
2022
accepted:
24
10
2022
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
Takayasu arteritis (TA) is a chronic granulomatous vasculitis involving in the main branches of aorta. Previous studies mainly used peripheral blood and some vascular tissues but seldom studies have sequenced vascular tissues. Here in this study, we aimed to explore the alterations of mRNA in TA by performing bulk RNA sequencing. A total of 14 abdominal aortic tissues including 8 from renal transplantation and 6 from patient with TA undergoing bypass surgeries. Bulk RNA sequencing were performed and after the quality control, a total of 1897 transcripts were observed to be significantly differently (
Identifiants
pubmed: 36468014
doi: 10.3389/fgene.2022.1036233
pii: 1036233
pmc: PMC9709398
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1036233Informations de copyright
Copyright © 2022 Yuqing, Shang, Qing, Jiyang, Ruihao, Zuoguan, Yongpeng, Zhiyuan and Yongjun.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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