Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules.

breast cancer magnetic manipulation nanocapsules paclitaxel photothermal therapy

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
14 02 2023
Historique:
pubmed: 6 12 2022
medline: 17 2 2023
entrez: 5 12 2022
Statut: ppublish

Résumé

With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally boost the drug therapeutic action at ultralow drug concentrations. The MAPSULES are composed of paclitaxel-loaded polylactic-

Identifiants

pubmed: 36468629
doi: 10.1021/acsnano.2c05733
pmc: PMC9933591
doi:

Substances chimiques

Nanocapsules 0
Iron E1UOL152H7
Paclitaxel P88XT4IS4D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1946-1958

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Auteurs

Arnon Fluksman (A)

Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9190501Jerusalem, Israel.

Aritz Lafuente (A)

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193 Bellaterra, Barcelona, Spain.
Universitat Autònoma de Barcelona, Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain.

Zhi Li (Z)

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193 Bellaterra, Barcelona, Spain.

Jordi Sort (J)

Universitat Autònoma de Barcelona, Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain.
ICREA, Pg. Lluís Companys 23, 08010Barcelona, Spain.

Silvia Lope-Piedrafita (S)

Universitat Autònoma de Barcelona, Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain.

Maria José Esplandiu (MJ)

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193 Bellaterra, Barcelona, Spain.

Josep Nogues (J)

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193 Bellaterra, Barcelona, Spain.
ICREA, Pg. Lluís Companys 23, 08010Barcelona, Spain.

Alejandro G Roca (AG)

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, 08193 Bellaterra, Barcelona, Spain.

Ofra Benny (O)

Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9190501Jerusalem, Israel.

Borja Sepulveda (B)

Instituto de Microelectronica de Barcelona (IMB-CNM, CSIC), Campus UAB, 08193 Bellaterra, Barcelona, Spain.

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Classifications MeSH