Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome.

Humans Retrospective Studies Respiratory Distress Syndrome / therapy Respiration Italy Respiratory Dead Space Respiration, Artificial
ARDS dead space mechanical ventilation venous admixture ventilatory ratio

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
03 2023
Historique:
received: 16 08 2022
revised: 12 10 2022
accepted: 13 10 2022
pubmed: 6 12 2022
medline: 25 2 2023
entrez: 5 12 2022
Statut: ppublish

Résumé

Ventilatory ratio (VR) has been proposed as an alternative approach to estimate physiological dead space. However, the absolute value of VR, at constant dead space, might be affected by venous admixture and CO This was a retrospective, observational study of mechanically ventilated patients with acute respiratory distress syndrome (ARDS) in the UK and Italy. Venous admixture was either directly measured or estimated using the surrogate measure Pa A total of 641 mechanically ventilated patients with mild (n=65), moderate (n=363), or severe (n=213) ARDS were studied. Venous admixture was measured (n=153 patients) or estimated using the Pa VR is a useful aggregate variable associated with outcome, but variables not associated with ventilation (VCO

Sections du résumé

BACKGROUND
Ventilatory ratio (VR) has been proposed as an alternative approach to estimate physiological dead space. However, the absolute value of VR, at constant dead space, might be affected by venous admixture and CO
METHODS
This was a retrospective, observational study of mechanically ventilated patients with acute respiratory distress syndrome (ARDS) in the UK and Italy. Venous admixture was either directly measured or estimated using the surrogate measure Pa
RESULTS
A total of 641 mechanically ventilated patients with mild (n=65), moderate (n=363), or severe (n=213) ARDS were studied. Venous admixture was measured (n=153 patients) or estimated using the Pa
CONCLUSIONS
VR is a useful aggregate variable associated with outcome, but variables not associated with ventilation (VCO

Identifiants

DOI: 10.1016/j.bja.2022.10.035 PMID: 36470747 PMC: PMC9718027
pubmed: 36470747
pii: S0007-0912(22)00624-9
doi: 10.1016/j.bja.2022.10.035
pmc: PMC9718027
pii:
doi:

Types de publication

Observational Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

360-367

Informations de copyright

Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Auteurs

Roberta Maj (R)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Paola Palermo (P)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Simone Gattarello (S)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Serena Brusatori (S)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Rosanna D'Albo (R)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Carmelo Zinnato (C)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Mara Velati (M)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Federica Romitti (F)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Mattia Busana (M)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Johannes Wieditz (J)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Peter Herrmann (P)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Onnen Moerer (O)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Micheal Quintel (M)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Konrad Meissner (K)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany.

Barnaby Sanderson (B)

Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences, London, UK.

Davide Chiumello (D)

Department of Anaesthesiology and Intensive Care, ASST Santi Paolo e Carlo Hospital, University of Milan, Milan, Italy.

John J Marini (JJ)

Department of Pulmonary and Critical Care Medicine, Regions Hospital, St. Paul, MN, USA.

Luigi Camporota (L)

Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences, London, UK.

Luciano Gattinoni (L)

Department of Anaesthesiology, Medical University of Göttingen, University Medical Centre Göttingen, Göttingen, Germany. Electronic address: gattinoniluciano@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Régions géographiques › Europe › Italie › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Espace mort respiratoire › Ventilatory ratio, dead space, and venous...
questionsmedicales.fr › Thérapeutique › Thérapie respiratoire › Ventilation artificielle › Ventilatory ratio, dead space, and venous...