The evolutionary and functional significance of germline immunoglobulin gene variation.
adaptive immunity
affinity maturation
immunoglobulin
population genetics
somatic hypermutation
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
25
10
2022
accepted:
07
11
2022
pubmed:
6
12
2022
medline:
4
1
2023
entrez:
5
12
2022
Statut:
ppublish
Résumé
The recombination between immunoglobulin (IG) gene segments determines an individual's naïve antibody repertoire and, consequently, (auto)antigen recognition. Emerging evidence suggests that mammalian IG germline variation impacts humoral immune responses associated with vaccination, infection, and autoimmunity - from the molecular level of epitope specificity, up to profound changes in the architecture of antibody repertoires. These links between IG germline variants and immunophenotype raise the question on the evolutionary causes and consequences of diversity within IG loci. We discuss why the extreme diversity in IG loci remains a mystery, why resolving this is important for the design of more effective vaccines and therapeutics, and how recent evidence from multiple lines of inquiry may help us do so.
Identifiants
pubmed: 36470826
pii: S1471-4906(22)00236-8
doi: 10.1016/j.it.2022.11.001
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-21Subventions
Organisme : NIAID NIH HHS
ID : R24 AI162317
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM135004
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI138963
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests V.G. declares advisory board positions in aiNET GmbH, Enpicom B.V, Specifica Inc, Adaptyv Biosystems, EVQLV, Omniscope, Diagonal Therapeutics, and Absci. V.G. is a consultant for Roche/Genentech, immunai, and Proteinea.