Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 12 2022
05 12 2022
Historique:
received:
08
09
2022
accepted:
30
11
2022
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
19
1
2023
Statut:
epublish
Résumé
Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64-68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging.
Identifiants
pubmed: 36470934
doi: 10.1038/s41598-022-25503-9
pii: 10.1038/s41598-022-25503-9
pmc: PMC9722656
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20957Informations de copyright
© 2022. The Author(s).
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