Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia.


Journal

Nature reviews. Rheumatology
ISSN: 1759-4804
Titre abrégé: Nat Rev Rheumatol
Pays: United States
ID NLM: 101500080

Informations de publication

Date de publication:
01 2023
Historique:
accepted: 04 11 2022
pubmed: 6 12 2022
medline: 24 12 2022
entrez: 5 12 2022
Statut: ppublish

Résumé

Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other symptoms, and has a substantial socioeconomic impact. Current biomedical and psychosocial treatments are unsatisfactory for many patients, and treatment progress has been hindered by the lack of a clear understanding of the pathogenesis of fibromyalgia. We present here a model of fibromyalgia that integrates current psychosocial and neurophysiological observations. We propose that an imbalance in emotion regulation, reflected by an overactive 'threat' system and underactive 'soothing' system, might keep the 'salience network' (also known as the midcingulo-insular network) in continuous alert mode, and this hyperactivation, in conjunction with other mechanisms, contributes to fibromyalgia. This proposed integrative model, which we term the Fibromyalgia: Imbalance of Threat and Soothing Systems (FITSS) model, should be viewed as a working hypothesis with limited supporting evidence available. We hope, however, that this model will shed new light on existing psychosocial and biological observations, and inspire future research to address the many gaps in our knowledge about fibromyalgia, ultimately stimulating the development of novel therapeutic interventions.

Identifiants

pubmed: 36471023
doi: 10.1038/s41584-022-00873-6
pii: 10.1038/s41584-022-00873-6
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

44-60

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022. Springer Nature Limited.

Références

Harris, R. E. & Clauw, D. J. How do we know that the pain in fibromyalgia is “real”? Curr. Pain. Headache Rep. 10, 403–407 (2006).
pubmed: 17087863 doi: 10.1007/s11916-006-0069-0
Borchers, A. T. & Gershwin, M. E. Fibromyalgia: a critical and comprehensive review. Clin. Rev. Allergy Immunol. 49, 100–151 (2015).
pubmed: 26445775 doi: 10.1007/s12016-015-8509-4
Häuser, W. et al. Fibromyalgia. Nat. Rev. Dis. Prim. 1, 15022 (2015).
pubmed: 27189527 doi: 10.1038/nrdp.2015.22
Sarzi-Puttini, P., Giorgi, V., Marotto, D. & Atzeni, F. Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment. Nat. Rev. Rheumatol. 16, 645–660 (2020).
pubmed: 33024295 doi: 10.1038/s41584-020-00506-w
Clauw, D. J., Arnold, L. M. & McCarberg, B. H. The science of fibromyalgia. Mayo Clin. Proc. 86, 907–911 (2011).
pubmed: 21878603 pmcid: 3258006 doi: 10.4065/mcp.2011.0206
Woolf, C. J. Pain amplification — a perspective on the how, why, when, and where of central sensitization. J. Appl. Biobehav. Res. 23, e12124 (2018).
doi: 10.1111/jabr.12124
Häuser, W., Walitt, B., Fitzcharles, M. A. & Sommer, C. Review of pharmacological therapies in fibromyalgia syndrome. Arthritis Res. Ther. 16, 201 (2014).
pubmed: 24433463 pmcid: 3979124 doi: 10.1186/ar4441
Nüesch, E., Häuser, W., Bernardy, K., Barth, J. & Juni, P. Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis. Ann. Rheum. Dis. 72, 955–962 (2013).
pubmed: 22739992 doi: 10.1136/annrheumdis-2011-201249
Gilbert, P. Defence and safety: their function in social behaviour and psychopathology. Br. J. Clin. Psychol. 32, 131–153 (1993).
pubmed: 8318932 doi: 10.1111/j.2044-8260.1993.tb01039.x
Gilbert, P. Compassion: Conceptualisations, Research and Use in Psychotherapy (Routledge, 2005).
Sluka, K. A. & Clauw, D. J. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience 338, 114–129 (2016).
pubmed: 27291641 doi: 10.1016/j.neuroscience.2016.06.006
Littlejohn, G. Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome. Nat. Rev. Rheumatol. 11, 639–648 (2015).
pubmed: 26241184 doi: 10.1038/nrrheum.2015.100
Harte, S. E., Harris, R. E. & Clauw, D. J. The neurobiology of central sensitization. J. Appl. Biobehav. Res. 23, e12137 (2018).
doi: 10.1111/jabr.12137
Pinto, A. M. et al. An updated overview of the neurophysiological and psychosocial dimensions of fibromyalgia — a call for an integrative model. Preprint at https://www.preprints.org/manuscript/202007.0224/v1 (2020).
Kato, K., Sullivan, P. F., Evengård, B. & Pedersen, N. L. Importance of genetic influences on chronic widespread pain. Arthritis Rheum. 54, 1682–1686 (2006).
pubmed: 16646040 doi: 10.1002/art.21798
Ablin, J. N. & Buskila, D. Update on the genetics of the fibromyalgia syndrome. Best. Pract. Res. Clin. Rheumatol. 29, 20–28 (2015).
pubmed: 26266996 doi: 10.1016/j.berh.2015.04.018
Park, D. J. & Lee, S. S. New insights into the genetics of fibromyalgia. Korean J. Intern. Med. 32, 984–995 (2017).
pubmed: 29056037 pmcid: 5668398 doi: 10.3904/kjim.2016.207
D’Agnelli, S. et al. Fibromyalgia: genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers. Mol. Pain. 15, 1744806918819944 (2019).
pubmed: 30486733 doi: 10.1177/1744806918819944
Veasley, C. et al. Impact of chronic overlapping pain conditions on public health and the urgent need for safe and effective treatment: 2015 analysis and policy recommendations. http://www.chronicpainresearch.org/public/CPRA_WhitePaper_2015-FINAL-Digital.pdf (2015).
Maixner, W., Fillingim, R. B., Williams, D. A., Smith, S. B. & Slade, G. D. Overlapping chronic pain conditions: implications for diagnosis and classification. J. Pain. 17, T93–T107 (2016).
pubmed: 27586833 pmcid: 6193199 doi: 10.1016/j.jpain.2016.06.002
Schrepf, A. et al. ICD-10 codes for the study of chronic overlapping pain conditions in administrative databases. J. Pain. 21, 59–70 (2020).
pubmed: 31154033 doi: 10.1016/j.jpain.2019.05.007
Veasley, C. in Fibromyalgia Syndrome and Widespread Pain: From Construction to Relevant Recognition (eds Häuser, W. & Perrot, S.) 87–111 (Wolters Kluwer Health, 2018).
Nicholas, M. et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 160, 28–37 (2019).
pubmed: 30586068 doi: 10.1097/j.pain.0000000000001390
Yunus, M. B. Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin. Arthritis Rheum. 37, 339–352 (2008).
pubmed: 18191990 doi: 10.1016/j.semarthrit.2007.09.003
Melzack, R. From the gate to the neuromatrix. Pain Suppl 6, S121–S126 (1999).
pubmed: 10491980 doi: 10.1016/S0304-3959(99)00145-1
Melzack, R. Pain and the neuromatrix in the brain. J. Dent. Educ. 65, 1378–1382 (2001).
pubmed: 11780656 doi: 10.1002/j.0022-0337.2001.65.12.tb03497.x
Apkarian, A. V., Bushnell, M. C., Treede, R. D. & Zubieta, J. K. Human brain mechanisms of pain perception and regulation in health and disease. Eur. J. Pain. 9, 463–484 (2005).
pubmed: 15979027 doi: 10.1016/j.ejpain.2004.11.001
Brosschot, J. F., Verkuil, B. & Thayer, J. F. The default response to uncertainty and the importance of perceived safety in anxiety and stress: an evolution-theoretical perspective. J. Anxiety Disord. 41, 22–34 (2016).
pubmed: 27259803 doi: 10.1016/j.janxdis.2016.04.012
Brosschot, J. F., Verkuil, B. & Thayer, J. F. Generalized unsafety theory of stress: unsafe environments and conditions, and the default stress response. Int. J. Environ. Res. Public Health 15, 464 (2018).
pubmed: 29518937 pmcid: 5877009 doi: 10.3390/ijerph15030464
Meeus, M. et al. Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin. Arthritis Rheum. 43, 279–287 (2013).
pubmed: 23838093 doi: 10.1016/j.semarthrit.2013.03.004
Reyes Del Paso, G. A., Garrido, S., Pulgar, A., Martín-Vázquez, M. & Duschek, S. Aberrances in autonomic cardiovascular regulation in fibromyalgia syndrome and their relevance for clinical pain reports. Psychosom. Med. 72, 462–470 (2010).
pubmed: 20467004 doi: 10.1097/PSY.0b013e3181da91f1
Reyes del Paso, G. A., Garrido, S., Pulgar, Á. & Duschek, S. Autonomic cardiovascular control and responses to experimental pain stimulation in fibromyalgia syndrome. J. Psychosom. Res. 70, 125–134 (2011).
pubmed: 21262414 doi: 10.1016/j.jpsychores.2010.09.012
Martinez-Lavin, M. Fibromyalgia as a sympathetically maintained pain syndrome. Curr. Pain. Headache Rep. 8, 385–389 (2004).
pubmed: 15361323 doi: 10.1007/s11916-996-0012-4
Furlan, R. et al. Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia. J. Rheumatol. 32, 1787–1793 (2005).
pubmed: 16142879
Reyes Del Paso, G. A. & de la Coba, P. Reduced activity, reactivity and functionality of the sympathetic nervous system in fibromyalgia: an electrodermal study. PLoS One 15, e0241154 (2020).
pubmed: 33119628 pmcid: 7595305 doi: 10.1371/journal.pone.0241154
Rivat, C. et al. Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia. Pain 150, 358–368 (2010).
pubmed: 20573451 doi: 10.1016/j.pain.2010.05.031
Malin, K. & Littlejohn, G. O. Stress modulates key psychological processes and characteristic symptoms in females with fibromyalgia. Clin. Exp. Rheumatol. 31, S64–S71 (2013).
pubmed: 24143887
Jennings, E. M., Okine, B. N., Roche, M. & Finn, D. P. Stress-induced hyperalgesia. Prog. Neurobiol. 121, 1–18 (2014).
pubmed: 25010858 doi: 10.1016/j.pneurobio.2014.06.003
Critchley, H. D. & Harrison, N. A. Visceral influences on brain and behavior. Neuron 77, 624–638 (2013).
pubmed: 23439117 doi: 10.1016/j.neuron.2013.02.008
Critchley, H. D. & Garfinkel, S. N. Interoception and emotion. Curr. Opin. Psychol. 17, 7–14 (2017).
pubmed: 28950976 doi: 10.1016/j.copsyc.2017.04.020
Rost, S., Van Ryckeghem, D. M., Schulz, A., Crombez, G. & Vögele, C. Generalized hypervigilance in fibromyalgia: normal interoceptive accuracy, but reduced self-regulatory capacity. J. Psychosom. Res. 93, 48–54 (2017).
pubmed: 28107892 doi: 10.1016/j.jpsychores.2016.12.003
Valenzuela-Moguillansky, C., Reyes-Reyes, A. & Gaete, M. I. Exteroceptive and interoceptive body-self awareness in fibromyalgia patients. Front. Hum. Neurosci. 11, 117 (2017).
pubmed: 28348526 pmcid: 5346579 doi: 10.3389/fnhum.2017.00117
Duschek, S., Montoro, C. I. & Reyes Del Paso, G. A. Diminished interoceptive awareness in fibromyalgia syndrome. Behav. Med. 43, 100–107 (2017).
pubmed: 26431269 doi: 10.1080/08964289.2015.1094442
Martínez, E. et al. Embodied pain in fibromyalgia: disturbed somatorepresentations and increased plasticity of the body schema. PLoS One 13, e0194534 (2018).
pubmed: 29624596 pmcid: 5889164 doi: 10.1371/journal.pone.0194534
Kool, M. B. & Geenen, R. Loneliness in patients with rheumatic diseases: the significance of invalidation and lack of social support. J. Psychol. 146, 229–241 (2012).
pubmed: 22303622 doi: 10.1080/00223980.2011.606434
Kool, M. B., van Middendorp, H., Boeije, H. R. & Geenen, R. Understanding the lack of understanding: invalidation from the perspective of the patient with fibromyalgia. Arthritis Rheum. 61, 1650–1656 (2009).
pubmed: 19950317 doi: 10.1002/art.24922
Kool, M. B. et al. Lack of understanding in fibromyalgia and rheumatoid arthritis: the Illness Invalidation Inventory (3*I). Ann. Rheum. Dis. 69, 1990–1995 (2010).
pubmed: 20498203 doi: 10.1136/ard.2009.123224
Santiago, M. G., Marques, A., Kool, M., Geenen, R. & da Silva, J. A. P. Invalidation in patients with rheumatic diseases: clinical and psychological framework. J. Rheumatol. 44, 512–518 (2017).
pubmed: 28202742 doi: 10.3899/jrheum.160559
Karayannis, N. V., Baumann, I., Sturgeon, J. A., Melloh, M. & Mackey, S. C. The impact of social isolation on pain interference: a longitudinal study. Ann. Behav. Med. 53, 65–74 (2019).
pubmed: 29668841 doi: 10.1093/abm/kay017
Wolf, L. D., Davis, M. C., Yeung, E. W. & Tennen, H. A. The within-day relation between lonely episodes and subsequent clinical pain in individuals with fibromyalgia: mediating role of pain cognitions. J. Psychosom. Res. 79, 202–206 (2015).
pubmed: 25637526 pmcid: 4496321 doi: 10.1016/j.jpsychores.2014.12.018
Landa, A. et al. When it hurts even more: the neural dynamics of pain and interpersonal emotions. J. Psychosom. Res. 128, 109881 (2020).
pubmed: 31835079 doi: 10.1016/j.jpsychores.2019.109881
Eisenberger, N. I., Moieni, M., Inagaki, T. K., Muscatell, K. A. & Irwin, M. R. In sickness and in health: the co-regulation of inflammation and social behavior. Neuropsychopharmacology 42, 242–253 (2017).
pubmed: 27480575 doi: 10.1038/npp.2016.141
Losin, E. A. R. et al. Neural and sociocultural mediators of ethnic differences in pain. Nat. Hum. Behav. 4, 517–530 (2020).
pubmed: 32015488 pmcid: 7494052 doi: 10.1038/s41562-020-0819-8
De Ruddere, L., Bosmans, M., Crombez, G. & Goubert, L. Patients are socially excluded when their pain has no medical explanation. J. Pain. 17, 1028–1035 (2016).
pubmed: 27349508 doi: 10.1016/j.jpain.2016.06.005
De Ruddere, L. & Craig, K. D. Understanding stigma and chronic pain: a-state-of-the-art review. Pain 157, 1607–1610 (2016).
pubmed: 26859821 doi: 10.1097/j.pain.0000000000000512
Asbring, P. & Närvänen, A. L. Women’s experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia. Qual. Health Res. 12, 148–160 (2002).
pubmed: 11837367
Häuser, W. et al. Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in fibromyalgia syndrome: a comparison of US and German outpatients. Clin. Exp. Rheumatol. 33, S86–S92 (2015).
pubmed: 25786049 pmcid: 4750383
Yavne, Y., Amital, D., Watad, A., Tiosano, S. & Amital, H. A systematic review of precipitating physical and psychological traumatic events in the development of fibromyalgia. Semin. Arthritis Rheum. 48, 121–133 (2018).
pubmed: 29428291 doi: 10.1016/j.semarthrit.2017.12.011
Kivimäki, M. et al. Work stress and incidence of newly diagnosed fibromyalgia: prospective cohort study. J. Psychosom. Res. 57, 417–422 (2004).
pubmed: 15581643
Malin, K. & Littlejohn, G. O. Rumination modulates stress and other psychological processes in fibromyalgia. Eur. J. Rheumatol. 2, 143–148 (2015).
pubmed: 27708952 pmcid: 5047227 doi: 10.5152/eurjrheum.2015.0005
Ricci, A. et al. Worry and anger rumination in fibromyalgia syndrome. Reumatismo 68, 195–198 (2016).
pubmed: 28299918 doi: 10.4081/reumatismo.2016.896
van Houdenhove, B. et al. Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study. Psychother. Psychosom. 71, 207–213 (2002).
pubmed: 12097786 doi: 10.1159/000063646
Malin, K. & Littlejohn, G. O. Personality and fibromyalgia syndrome. Open Rheumatol. J. 6, 273–285 (2012).
pubmed: 23002409 pmcid: 3447191 doi: 10.2174/1874312901206010273
Hassett, A. L., Cone, J. D., Patella, S. J. & Sigal, L. H. The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome. Arthritis Rheum. 43, 2493–2500 (2000).
pubmed: 11083273 doi: 10.1002/1529-0131(200011)43:11<2493::AID-ANR17>3.0.CO;2-W
Hassett, A. L. et al. The relationship between affect balance style and clinical outcomes in fibromyalgia. Arthritis Rheum. 59, 833–840 (2008).
pubmed: 18512724 doi: 10.1002/art.23708
Davis, M. C., Zautra, A. J. & Reich, J. W. Vulnerability to stress among women in chronic pain from fibromyalgia and osteoarthritis. Ann. Behav. Med. 23, 215–226 (2001).
pubmed: 11495222 doi: 10.1207/S15324796ABM2303_9
Zautra, A. J. et al. Fibromyalgia: evidence for deficits in positive affect regulation. Psychosom. Med. 67, 147–155 (2005).
pubmed: 15673637 pmcid: 2583466 doi: 10.1097/01.psy.0000146328.52009.23
van Middendorp, H. et al. Emotions and emotional approach and avoidance strategies in fibromyalgia. J. Psychosom. Res. 64, 159–167 (2008).
pubmed: 18222129 doi: 10.1016/j.jpsychores.2007.08.009
González, J. L. et al. Sources of stress and recovery as concurrent predictors of the affect balance of patients with fibromyalgia. Psychol. Rep. 117, 656–673 (2015).
pubmed: 26595294 doi: 10.2466/15.20.PR0.117c29z0
Estévez-López, F. et al. Adaptation profiles comprising objective and subjective measures in fibromyalgia: the al-Ándalus project. Rheumatology 56, 2015–2024 (2017).
pubmed: 28968914 doi: 10.1093/rheumatology/kex302
Wentz, K. A., Lindberg, C. & Hallberg, L. R. Psychological functioning in women with fibromyalgia: a grounded theory study. Health Care Women Int. 25, 702–729 (2004).
pubmed: 15371077 doi: 10.1080/07399330490475575
Eisenlohr-Moul, T. A. et al. Parasympathetic reactivity in fibromyalgia and temporomandibular disorder: associations with sleep problems, symptom severity, and functional impairment. J. Pain. 16, 247–257 (2015).
pubmed: 25542636 doi: 10.1016/j.jpain.2014.12.005
Wolfe, F. Fibromyalgianess. Arthritis Rheum. 61, 715–716 (2009).
pubmed: 19479689 doi: 10.1002/art.24553
Häuser, W., Schmutzer, G., Brähler, E. & Glaesmer, H. A cluster within the continuum of biopsychosocial distress can be labeled “fibromyalgia syndrome” — evidence from a representative German population survey. J. Rheumatol. 36, 2806–2812 (2009).
pubmed: 19918039 doi: 10.3899/jrheum.090579
Wolfe, F., Brähler, E., Hinz, A. & Häuser, W. Fibromyalgia prevalence, somatic symptom reporting, and the dimensionality of polysymptomatic distress: results from a survey of the general population. Arthritis Care Res. 65, 777–785 (2013).
doi: 10.1002/acr.21931
Gilbert, P. Compassion Focused Therapy: Distinctive Features (Routledge, 2010).
Panksepp, J. Affective Neuroscience: The Foundations of Human and Animal Emotions (Oxford University Press, 1998).
LeDoux, J. The Emotional Brain: The Mysterious Underpinnings of Emotional Life (Simon and Schuster, 1998).
LeDoux, J. & Daw, N. D. Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour. Nat. Rev. Neurosci. 19, 269–282 (2018).
pubmed: 29593300 doi: 10.1038/nrn.2018.22
Duarte, J., McEwan, K., Barnes, C., Gilbert, P. & Maratos, F. A. Do therapeutic imagery practices affect physiological and emotional indicators of threat in high self-critics? Psychol. Psychother. 88, 270–284 (2015).
pubmed: 25347984 doi: 10.1111/papt.12043
Roelofs, K. Freeze for action: neurobiological mechanisms in animal and human freezing. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 372, 20160206 (2017).
pubmed: 28242739 pmcid: 5332864 doi: 10.1098/rstb.2016.0206
Depue, R. A. & Morrone-Strupinsky, J. V. A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. Behav. Brain. Sci. 28, 313–350 (2005).
pubmed: 16209725 doi: 10.1017/S0140525X05000063
Berridge, K. C. & Kringelbach, M. L. Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology 199, 457–480 (2008).
pubmed: 18311558 pmcid: 3004012 doi: 10.1007/s00213-008-1099-6
Berridge, K. C. & Kringelbach, M. L. Pleasure systems in the brain. Neuron 86, 646–664 (2015).
pubmed: 25950633 pmcid: 4425246 doi: 10.1016/j.neuron.2015.02.018
Gilbert, P. Introducing compassion-focused therapy. Adv. Psychiatr. Treat. 15, 199–208 (2009).
doi: 10.1192/apt.bp.107.005264
Gilbert, P. Compassion: from its evolution to a psychotherapy. Front. Psychol. 11, 586161 (2020).
pubmed: 33362650 pmcid: 7762265 doi: 10.3389/fpsyg.2020.586161
Eippert, F. et al. Regulation of emotional responses elicited by threat-related stimuli. Hum. Brain Mapp. 28, 409–423 (2007).
pubmed: 17133391 doi: 10.1002/hbm.20291
Longe, O. et al. Having a word with yourself: neural correlates of self-criticism and self-reassurance. Neuroimage 49, 1849–1856 (2010).
pubmed: 19770047 doi: 10.1016/j.neuroimage.2009.09.019
Porges, S. W. The polyvagal perspective. Biol. Psychol. 74, 116–143 (2007).
pubmed: 17049418 doi: 10.1016/j.biopsycho.2006.06.009
Gilbert, P. Affiliative and prosocial motives and emotions in mental health. Dialogues Clin. Neurosci. 17, 381–389 (2015).
pubmed: 26869839 pmcid: 4734876 doi: 10.31887/DCNS.2015.17.4/pgilbert
Taylor, S. E. Tend and befriend: biobehavioral bases of affiliation under stress. Curr. Dir. Psychol. Sci. 15, 273–277 (2006).
doi: 10.1111/j.1467-8721.2006.00451.x
Kirsch, P. et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. J. Neurosci. 25, 11489–11493 (2005).
pubmed: 16339042 pmcid: 6725903 doi: 10.1523/JNEUROSCI.3984-05.2005
Tracy, L. M., Georgiou-Karistianis, N., Gibson, S. J. & Giummarra, M. J. Oxytocin and the modulation of pain experience: implications for chronic pain management. Neurosci. Biobehav. Rev. 55, 53–67 (2015).
pubmed: 25956252 doi: 10.1016/j.neubiorev.2015.04.013
Van Den Houte, M., Van Oudenhove, L., Bogaerts, K., Van Diest, I. & Van den Bergh, O. Endogenous pain modulation: association with resting heart rate variability and negative affectivity. Pain. Med. 19, 1587–1596 (2017).
doi: 10.1093/pm/pnx165
López-Solà, M., Geuter, S., Koban, L., Coan, J. A. & Wager, T. D. Brain mechanisms of social touch-induced analgesia in females. Pain 160, 2072–2085 (2019).
pubmed: 31241496 doi: 10.1097/j.pain.0000000000001599
Staud, R. Heart rate variability as a biomarker of fibromyalgia syndrome. Fut. Rheumatol. 3, 475–483 (2008).
pubmed: 19890437 pmcid: 2772072 doi: 10.2217/17460816.3.5.475
Jenewein, J. et al. Fear-learning deficits in subjects with fibromyalgia syndrome? Eur. J. Pain. 17, 1374–1384 (2013).
pubmed: 23468076 pmcid: 3929307 doi: 10.1002/j.1532-2149.2013.00300.x
Meulders, A., Jans, A. & Vlaeyen, J. W. S. Differences in pain-related fear acquisition and generalization: an experimental study comparing patients with fibromyalgia and healthy controls. Pain 156, 108–122 (2015).
pubmed: 25599307 doi: 10.1016/j.pain.0000000000000016
Meulders, A., Meulders, M., Stouten, I., De Bie, J. & Vlaeyen, J. W. Extinction of fear generalization: a comparison between fibromyalgia patients and healthy control participants. J. Pain. 18, 79–95 (2017).
pubmed: 27776989 doi: 10.1016/j.jpain.2016.10.004
Sandström, A. et al. Neural correlates of conditioned pain responses in fibromyalgia subjects indicate preferential formation of new pain associations rather than extinction of irrelevant ones. Pain 161, 2079–2088 (2020).
pubmed: 32379218 pmcid: 7431138 doi: 10.1097/j.pain.0000000000001907
Perry, B. D., Pollard, R. A., Blakley, T. L., Baker, W. L. & Vigilante, D. Childhood trauma, the neurobiology of adaptation, and “use-dependent” development of the brain: how “states” become “traits”. Infant Ment. Health J. 16, 271–291 (1995).
doi: 10.1002/1097-0355(199524)16:4<271::AID-IMHJ2280160404>3.0.CO;2-B
Chen, Y. & Baram, T. Z. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology 41, 197–206 (2016).
pubmed: 26105143 doi: 10.1038/npp.2015.181
Krugers, H. J. et al. Early life adversity: lasting consequences for emotional learning. Neurobiol. Stress. 6, 14–21 (2017).
pubmed: 28229105 doi: 10.1016/j.ynstr.2016.11.005
Brosschot, J. F., Verkuil, B. & Thayer, J. F. Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity. Neurosci. Biobehav. Rev. 74, 287–296 (2017).
pubmed: 27471146 doi: 10.1016/j.neubiorev.2016.07.019
Bowlby, J. in Attachment and Loss: Volume II: Separation, Anxiety and Anger 1–429 (The Hogarth Press and the Institute of Psycho-analysis, 1973).
Mikulincer, M., Shaver, P. R. & Pereg, D. Attachment theory and affect regulation: the dynamics, development, and cognitive consequences of attachment-related strategies. Motiv. Emot. 27, 77–102 (2003).
doi: 10.1023/A:1024515519160
Schore, A. N. The effects of early relational trauma on right brain development, affect regulation, and infant mental health. Infant. Ment. Health J. 22, 201–269 (2001).
doi: 10.1002/1097-0355(200101/04)22:1<201::AID-IMHJ8>3.0.CO;2-9
Hornstein, E. A. & Eisenberger, N. I. Unpacking the buffering effect of social support figures: social support attenuates fear acquisition. PLoS ONE 12, e0175891 (2017).
pubmed: 28463999 pmcid: 5413011 doi: 10.1371/journal.pone.0175891
Krahé, C., Springer, A., Weinman, J. A. & Fotopoulou, A. The social modulation of pain: others as predictive signals of salience — a systematic review. Front. Hum. Neurosci. 7, 386 (2013).
pubmed: 23888136 pmcid: 3719078 doi: 10.3389/fnhum.2013.00386
Hostinar, C. E. & Gunnar, M. R. Social support can buffer against stress and shape brain activity. AJOB Neurosci. 6, 34–42 (2015).
pubmed: 26478822 pmcid: 4607089 doi: 10.1080/21507740.2015.1047054
Pilcher, J. J. & Bryant, S. A. Implications of social support as a self-control resource. Front. Behav. Neurosci. 10, 228 (2016).
pubmed: 27965551 pmcid: 5124711 doi: 10.3389/fnbeh.2016.00228
Eisenberger, N. I. et al. Attachment figures activate a safety signal-related neural region and reduce pain experience. Proc. Natl Acad. Sci. USA 108, 11721–11726 (2011).
pubmed: 21709271 pmcid: 3136329 doi: 10.1073/pnas.1108239108
Younger, J., Aron, A., Parke, S., Chatterjee, N. & Mackey, S. Viewing pictures of a romantic partner reduces experimental pain: involvement of neural reward systems. PLoS One 5, e13309 (2010).
pubmed: 20967200 pmcid: 2954158 doi: 10.1371/journal.pone.0013309
Häuser, W., Kosseva, M., Uceyler, N., Klose, P. & Sommer, C. Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. Arthritis Care Res. 63, 808–820 (2011).
doi: 10.1002/acr.20328
Davies, K. A., Macfarlane, G. J., McBeth, J., Morriss, R. & Dickens, C. Insecure attachment style is associated with chronic widespread pain. Pain 143, 200–205 (2009).
pubmed: 19345016 pmcid: 2806947 doi: 10.1016/j.pain.2009.02.013
Wang, H., Weber, A., Schiltenwolf, M. & Amelung, D. [Attachment style and cytokine levels in patients with fibromyalgia. A prospective longitudinal study]. Schmerz 28, 504–512 (2014).
pubmed: 25034652 doi: 10.1007/s00482-014-1461-z
Peñacoba, C., Perez-Calvo, S., Blanco, S. & Sanroman, L. Attachment styles, pain intensity and emotional variables in women with fibromyalgia. Scand. J. Caring Sci. 32, 535–544 (2018).
pubmed: 28885733 doi: 10.1111/scs.12477
Jones, G. T. et al. Role of road traffic accidents and other traumatic events in the onset of chronic widespread pain: results from a population-based prospective study. Arthritis Care Res. 63, 696–701 (2011).
doi: 10.1002/acr.20417
Burke, N. N., Finn, D. P., McGuire, B. E. & Roche, M. Psychological stress in early life as a predisposing factor for the development of chronic pain: clinical and preclinical evidence and neurobiological mechanisms. J. Neurosci. Res. 95, 1257–1270 (2017).
pubmed: 27402412 doi: 10.1002/jnr.23802
Jones, G. T., Power, C. & Macfarlane, G. J. Adverse events in childhood and chronic widespread pain in adult life: results from the 1958 British Birth Cohort Study. Pain 143, 92–96 (2009).
pubmed: 19304391 doi: 10.1016/j.pain.2009.02.003
Jay, M., Bendayan, R., Cooper, R. & Muthuri, S. Lifetime socioeconomic circumstances and chronic pain in later adulthood: findings from a British birth cohort study. BMJ Open 9, e024250 (2019).
pubmed: 30850405 pmcid: 6429846 doi: 10.1136/bmjopen-2018-024250
Kaleycheva, N. et al. The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies. Psychol. Med. 51, 177–193 (2021).
pubmed: 33602373 doi: 10.1017/S0033291720004547
You, D. S. & Meagher, M. W. Childhood adversity and pain sensitization. Psychosom. Med. 78, 1084–1093 (2016).
pubmed: 27755280 doi: 10.1097/PSY.0000000000000399
Sturycz, C. A. et al. Race/ethnicity does not moderate the relationship between adverse life experiences and temporal summation of the nociceptive flexion reflex and pain: results from the Oklahoma Study of Native American Pain Risk. J. Pain. 20, 941–955 (2019).
pubmed: 30776495 pmcid: 6689448 doi: 10.1016/j.jpain.2019.02.006
Kell, P. A. et al. The relationship between adverse life events and endogenous inhibition of pain and spinal nociception: findings from the Oklahoma Study of Native American Pain Risk (OK-SNAP). J. Pain. 22, 1097–1110 (2021).
pubmed: 33819573 pmcid: 8419014 doi: 10.1016/j.jpain.2021.03.146
Rhudy, J. L. et al. Emotional modulation of pain and spinal nociception in fibromyalgia. Pain 154, 1045–1056 (2013).
pubmed: 23622762 pmcid: 3679206 doi: 10.1016/j.pain.2013.03.025
Kamping, S., Bomba, I. C., Kanske, P., Diesch, E. & Flor, H. Deficient modulation of pain by a positive emotional context in fibromyalgia patients. Pain 154, 1846–1855 (2013).
pubmed: 23752177 doi: 10.1016/j.pain.2013.06.003
Loggia, M. L. et al. Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia. Arthritis Rheumatol. 66, 203–212 (2014).
pubmed: 24449585 pmcid: 4516215 doi: 10.1002/art.38191
Siegel, D. J. The Developing Mind: How Relationships and the Brain Interact to Shape Who We Are. 2nd edn. (The Guilford Press, 2012).
Mikulincer, M. & Shaver, P. R. Attachment in Adulthood: Structure, Dynamics, and Change (The Guilford Press, 2016).
Menon, V. in Brain Mapping: an Encyclopedic Reference vol. 2 (ed Toga, A.W) 597–611 (Academic Press, 2015).
Menon, V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn. Sci. 15, 483–506 (2011).
pubmed: 21908230 doi: 10.1016/j.tics.2011.08.003
Reddan, M. C., Wager, T. D. & Schiller, D. Attenuating neural threat expression with imagination. Neuron 100, 994–1005.e1004 (2018).
pubmed: 30465766 pmcid: 6314478 doi: 10.1016/j.neuron.2018.10.047
Wager, T. D. et al. An fMRI-based neurologic signature of physical pain. N. Engl. J. Med. 368, 1388–1397 (2013).
pubmed: 23574118 pmcid: 3691100 doi: 10.1056/NEJMoa1204471
Menon, V. & Uddin, L. Q. Saliency, switching, attention and control: a network model of insula function. Brain Struct. Funct. 214, 655–667 (2010).
pubmed: 20512370 pmcid: 2899886 doi: 10.1007/s00429-010-0262-0
Legrain, V., Iannetti, G. D., Plaghki, L. & Mouraux, A. The pain matrix reloaded: a salience detection system for the body. Prog. Neurobiol. 93, 111–124 (2011).
pubmed: 21040755 doi: 10.1016/j.pneurobio.2010.10.005
Miller, A. H., Haroon, E., Raison, C. L. & Felger, J. C. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 30, 297–306 (2013).
pubmed: 23468190 pmcid: 4141874 doi: 10.1002/da.22084
Uddin, L. Q. Salience Network of the Human Brain (Academic Press, 2017).
Uddin, L. Q., Yeo, B. T. T. & Spreng, R. N. Towards a universal taxonomy of macro-scale functional human brain networks. Brain Topogr. 32, 926–942 (2019).
pubmed: 31707621 pmcid: 7325607 doi: 10.1007/s10548-019-00744-6
López-Solà, M. et al. Towards a neurophysiological signature for fibromyalgia. Pain 158, 34–47 (2017).
pubmed: 27583567 pmcid: 5161739 doi: 10.1097/j.pain.0000000000000707
Buckner, R. L., Andrews-Hanna, J. R. & Schacter, D. L. The brain’s default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124, 1–38 (2008).
pubmed: 18400922 doi: 10.1196/annals.1440.011
Gracely, R. H., Petzke, F., Wolf, J. M. & Clauw, D. J. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum. 46, 1333–1343 (2002).
pubmed: 12115241 doi: 10.1002/art.10225
Cook, D. B. et al. Functional imaging of pain in patients with primary fibromyalgia. J. Rheumatol. 31, 364–378 (2004).
pubmed: 14760810
Pujol, J. et al. Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI. PLoS One 4, e5224 (2009).
pubmed: 19381292 pmcid: 2667672 doi: 10.1371/journal.pone.0005224
López-Solà, M. et al. Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients. Arthritis Rheumatol. 66, 3200–3209 (2014).
pubmed: 25220783 pmcid: 4410766 doi: 10.1002/art.38781
Harte, S. E. et al. Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula. Pain 157, 1933–1945 (2016).
pubmed: 27101425 pmcid: 4988086 doi: 10.1097/j.pain.0000000000000593
Harris, R. E. et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum. 60, 3146–3152 (2009).
pubmed: 19790053 pmcid: 2827610 doi: 10.1002/art.24849
Harris, R. E. et al. Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients. Anesthesiology 119, 1453–1464 (2013).
pubmed: 24343290 doi: 10.1097/ALN.0000000000000017
Ichesco, E. et al. Altered resting state connectivity of the insular cortex in individuals with fibromyalgia. J. Pain. 15, 815–826.e1 (2014).
pubmed: 24815079 pmcid: 4127388 doi: 10.1016/j.jpain.2014.04.007
Napadow, V. et al. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 62, 2545–2555 (2010).
pubmed: 20506181 pmcid: 2921024 doi: 10.1002/art.27497
Kim, J. Y. et al. Increased power spectral density in resting-state pain-related brain networks in fibromyalgia. Pain 154, 1792–1797 (2013).
pubmed: 23714266 doi: 10.1016/j.pain.2013.05.040
Pujol, J. et al. The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia. Pain 155, 1492–1503 (2014).
pubmed: 24792477 doi: 10.1016/j.pain.2014.04.028
Kaplan, C. M. et al. Functional and neurochemical disruptions of brain hub topology in chronic pain. Pain 160, 973–983 (2019).
pubmed: 30763287 pmcid: 6424595 doi: 10.1097/j.pain.0000000000001480
Ellingsen, D. M. et al. A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity. Pain 162, 1352–1363 (2021).
pubmed: 33230008 doi: 10.1097/j.pain.0000000000002134
Sridharan, D., Levitin, D. J. & Menon, V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc. Natl Acad. Sci. USA 105, 12569–12574 (2008).
pubmed: 18723676 pmcid: 2527952 doi: 10.1073/pnas.0800005105
Kennerley, S. W., Behrens, T. E. & Wallis, J. D. Double dissociation of value computations in orbitofrontal and anterior cingulate neurons. Nat. Neurosci. 14, 1581–1589 (2011).
pubmed: 22037498 pmcid: 3225689 doi: 10.1038/nn.2961
Wunderlich, K., Dayan, P. & Dolan, R. J. Mapping value based planning and extensively trained choice in the human brain. Nat. Neurosci. 15, 786–791 (2012).
pubmed: 22406551 pmcid: 3378641 doi: 10.1038/nn.3068
Margulies, D. S. & Uddin, L. Q. Network convergence zones in the anterior midcingulate cortex. Handb. Clin. Neurol. 166, 103–111 (2019).
pubmed: 31731907 doi: 10.1016/B978-0-444-64196-0.00007-8
Etkin, A. & Wager, T. D. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry 164, 1476–1488 (2007).
pubmed: 17898336 pmcid: 3318959 doi: 10.1176/appi.ajp.2007.07030504
Nagai, M., Kishi, K. & Kato, S. Insular cortex and neuropsychiatric disorders: a review of recent literature. Eur. Psychiatry 22, 387–394 (2007).
pubmed: 17416488 doi: 10.1016/j.eurpsy.2007.02.006
Nieuwenhuys, R. The insular cortex: a review. Prog. Brain Res. 195, 123–163 (2012).
pubmed: 22230626 doi: 10.1016/B978-0-444-53860-4.00007-6
Sterzer, P. & Kleinschmidt, A. Anterior insula activations in perceptual paradigms: often observed but barely understood. Brain Struct. Funct. 214, 611–622 (2010).
pubmed: 20512379 doi: 10.1007/s00429-010-0252-2
Travassos, C., Sayal, A., Direito, B., Castelhano, J. & Castelo-Branco, M. Volitional modulation of the left DLPFC neural activity based on a pain empathy paradigm — a potential novel therapeutic target for pain. Front. Neurol. 11, 714 (2020).
pubmed: 32793103 pmcid: 7394699 doi: 10.3389/fneur.2020.00714
Perini, I. et al. The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula. Sci. Rep. 8, 6165 (2018).
pubmed: 29670166 pmcid: 5906579 doi: 10.1038/s41598-018-24658-8
Kross, E., Berman, M. G., Mischel, W., Smith, E. E. & Wager, T. D. Social rejection shares somatosensory representations with physical pain. Proc. Natl Acad. Sci. USA 108, 6270–6275 (2011).
pubmed: 21444827 pmcid: 3076808 doi: 10.1073/pnas.1102693108
Eisenberger, N. I. Social pain and the brain: controversies, questions, and where to go from here. Annu. Rev. Psychol. 66, 601–629 (2015).
pubmed: 25251482 doi: 10.1146/annurev-psych-010213-115146
Beissner, F., Meissner, K., Bär, K.-J. & Napadow, V. The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. J. Neurosci. 33, 10503–10511 (2013).
pubmed: 23785162 pmcid: 3685840 doi: 10.1523/JNEUROSCI.1103-13.2013
Wager, T. D. et al. Brain mediators of cardiovascular responses to social threat: part I: reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. Neuroimage 47, 821–835 (2009).
pubmed: 19465137 doi: 10.1016/j.neuroimage.2009.05.043
Wager, T. D. et al. Brain mediators of cardiovascular responses to social threat, part II: prefrontal-subcortical pathways and relationship with anxiety. Neuroimage 47, 836–851 (2009).
pubmed: 19465135 doi: 10.1016/j.neuroimage.2009.05.044
Gianaros, P. J. & Wager, T. D. Brain-body pathways linking psychological stress and physical health. Curr. Dir. Psychol. Sci. 24, 313–321 (2015).
pubmed: 26279608 pmcid: 4535428 doi: 10.1177/0963721415581476
Thayer, J. F. & Lane, R. D. A model of neurovisceral integration in emotion regulation and dysregulation. J. Affect. Disord. 61, 201–216 (2000).
pubmed: 11163422 doi: 10.1016/S0165-0327(00)00338-4
Thayer, J. F. & Lane, R. D. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci. Biobehav. Rev. 33, 81–88 (2009).
pubmed: 18771686 doi: 10.1016/j.neubiorev.2008.08.004
Thayer, J. F., Ahs, F., Fredrikson, M., Sollers, J. J. & Wager, T. D. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci. Biobehav. Rev. 36, 747–756 (2012).
pubmed: 22178086 doi: 10.1016/j.neubiorev.2011.11.009
Mouraux, A. & Iannetti, G. D. Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity. J. Neurophysiol. 101, 3258–3269 (2009).
pubmed: 19339457 doi: 10.1152/jn.91181.2008
Baliki, M. N. & Apkarian, A. V. Nociception, pain, negative moods, and behavior selection. Neuron 87, 474–491 (2015).
pubmed: 26247858 pmcid: 4529956 doi: 10.1016/j.neuron.2015.06.005
Woo, C. W. et al. Separate neural representations for physical pain and social rejection. Nat. Commun. 5, 5380 (2014).
pubmed: 25400102 doi: 10.1038/ncomms6380
Kragel, P. A. et al. Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex. Nat. Neurosci. 21, 283–289 (2018).
pubmed: 29292378 pmcid: 5801068 doi: 10.1038/s41593-017-0051-7
Krishnan, A. et al. Somatic and vicarious pain are represented by dissociable multivariate brain patterns. Elife 5, e15166 (2016).
pubmed: 27296895 pmcid: 4907690 doi: 10.7554/eLife.15166
Uddin, L. Q., Iacoboni, M., Lange, C. & Keenan, J. P. The self and social cognition: the role of cortical midline structures and mirror neurons. Trends Cogn. Sci. 11, 153–157 (2007).
pubmed: 17300981 doi: 10.1016/j.tics.2007.01.001
Goulden, N. et al. The salience network is responsible for switching between the default mode network and the central executive network: replication from DCM. Neuroimage 99, 180–190 (2014).
pubmed: 24862074 doi: 10.1016/j.neuroimage.2014.05.052
Uddin, L. Q. Salience processing and insular cortical function and dysfunction. Nat. Rev. Neurosci. 16, 55–61 (2015).
pubmed: 25406711 doi: 10.1038/nrn3857
Schiller, D., Levy, I., Niv, Y., LeDoux, J. E. & Phelps, E. A. From fear to safety and back: reversal of fear in the human brain. J. Neurosci. 28, 11517–11525 (2008).
pubmed: 18987188 pmcid: 3844784 doi: 10.1523/JNEUROSCI.2265-08.2008
Woo, C. W. et al. Quantifying cerebral contributions to pain beyond nociception. Nat. Commun. 8, 14211 (2017).
pubmed: 28195170 pmcid: 5316889 doi: 10.1038/ncomms14211
Baliki, M. N. et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J. Neurosci. 26, 12165–12173 (2006).
pubmed: 17122041 pmcid: 4177069 doi: 10.1523/JNEUROSCI.3576-06.2006
Vachon-Presseau, E. et al. The emotional brain as a predictor and amplifier of chronic pain. J. Dent. Res. 95, 605–612 (2016).
pubmed: 26965423 pmcid: 4924545 doi: 10.1177/0022034516638027
Wiech, K. et al. Anterior insula integrates information about salience into perceptual decisions about pain. J. Neurosci. 30, 16324–16331 (2010).
pubmed: 21123578 pmcid: 6634837 doi: 10.1523/JNEUROSCI.2087-10.2010
Peyron, R. & Faillenot, I. [Functional brain mapping of pain perception]. Med. Sci. 27, 82–87 (2011).
Liu, C. H. et al. Increased salience network activity in patients with insomnia complaints in major depressive disorder. Front. Psychiatry 9, 93 (2018).
pubmed: 29615938 pmcid: 5869937 doi: 10.3389/fpsyt.2018.00093
Marques, D. R., Gomes, A. A., Caetano, G. & Castelo-Branco, M. Insomnia disorder and brain’s default-mode network. Curr. Neurol. Neurosci. Rep. 18, 45 (2018).
pubmed: 29886515 doi: 10.1007/s11910-018-0861-3
Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L. & Gotlib, I. H. Neural correlates of rumination in depression. Cogn. Affect. Behav. Neurosci. 10, 470–478 (2010).
pubmed: 21098808 pmcid: 4476645 doi: 10.3758/CABN.10.4.470
Kucyi, A. et al. Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination. J. Neurosci. 34, 3969–3975 (2014).
pubmed: 24623774 pmcid: 6705280 doi: 10.1523/JNEUROSCI.5055-13.2014
Servaas, M. N. et al. Connectomics and neuroticism: an altered functional network organization. Neuropsychopharmacology 40, 296–304 (2015).
pubmed: 25005250 doi: 10.1038/npp.2014.169
Schrepf, A. et al. Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study. Pain 157, 2217–2225 (2016).
pubmed: 27420606 pmcid: 5028286 doi: 10.1097/j.pain.0000000000000633
Rocchi, G. et al. Opioidergic system and functional architecture of intrinsic brain activity: implications for psychiatric disorders. Neuroscientist 26, 343–358 (2020).
pubmed: 32133917 doi: 10.1177/1073858420902360
Ballantyne, J. C. & Sullivan, M. D. Discovery of endogenous opioid systems: what it has meant for the clinician’s understanding of pain and its treatment. Pain 158, 2290–2300 (2017).
pubmed: 28832397 doi: 10.1097/j.pain.0000000000001043
Jensen, K. B. et al. Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain. Pain 144, 95–100 (2009).
pubmed: 19410366 doi: 10.1016/j.pain.2009.03.018
Jensen, K. B. et al. Patients with fibromyalgia display less functional connectivity in the brain’s pain inhibitory network. Mol. Pain. 8, 32 (2012).
pubmed: 22537768 pmcid: 3404927 doi: 10.1186/1744-8069-8-32
Jensen, K. B. et al. Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. Arthritis Rheum. 65, 3293–3303 (2013).
pubmed: 23982850 pmcid: 3984030 doi: 10.1002/art.38170
Baraniuk, J. N. et al. A chronic fatigue syndrome-related proteome in human cerebrospinal fluid. BMC Neurol. 5, 22 (2005).
pubmed: 16321154 pmcid: 1326206 doi: 10.1186/1471-2377-5-22
Macfarlane, G. J. et al. EULAR revised recommendations for the management of fibromyalgia. Ann. Rheum. Dis. 76, 318–328 (2017).
pubmed: 27377815 doi: 10.1136/annrheumdis-2016-209724
Grayston, R. et al. A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: implications for a new paradigm in fibromyalgia etiopathogenesis. Semin. Arthritis Rheum. 48, 933–940 (2018).
pubmed: 30314675 doi: 10.1016/j.semarthrit.2018.08.003
Harte, S. E. et al. Reduced intraepidermal nerve fiber density after a sustained increase in insular glutamate: a proof-of-concept study examining the pathogenesis of small fiber pathology in fibromyalgia. Pain. Rep. 2, e590 (2017).
pubmed: 29392206 pmcid: 5741296 doi: 10.1097/PR9.0000000000000590
Van Houdenhove, B. & Egle, U. T. Fibromyalgia: a stress disorder? Piecing the biopsychosocial puzzle together. Psychother. Psychosom. 73, 267–275 (2004).
pubmed: 15292624 doi: 10.1159/000078843
Martinez-Lavin, M. Fibromyalgia: when distress becomes (un)sympathetic pain. Pain. Res. Treat. 2012, 981565 (2012).
pubmed: 22110948
Lyon, P., Cohen, M. & Quintner, J. An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome). Pain. Med. 12, 1167–1178 (2011).
pubmed: 21692974 doi: 10.1111/j.1526-4637.2011.01168.x
Van Houdenhove, B. & Luyten, P. Central sensitivity syndromes: stress system failure may explain the whole picture. Semin. Arthritis Rheum. 39, 218–219 (2009).
pubmed: 18973930 doi: 10.1016/j.semarthrit.2008.08.008
Eccleston, C. Chronic pain as embodied defence: implications for current and future psychological treatments. Pain 159, S17–S23 (2018).
pubmed: 30113943 doi: 10.1097/j.pain.0000000000001286
Hill, P. Chronic pain: a consequence of dysregulated protective action. Br. J. Pain. 13, 13–21 (2019).
pubmed: 30671234 doi: 10.1177/2049463718799784
Penlington, C. Exploring a compassion-focused intervention for persistent pain in a group setting. Br. J. Pain. 13, 59–66 (2019).
pubmed: 30671240 doi: 10.1177/2049463718772148
Gooding, H., Stedmon, J. & Crix, D. ‘All these things don’t take the pain away but they do help you to accept it’: making the case for compassion-focused therapy in the management of persistent pain. Br. J. Pain. 14, 31–41 (2020).
pubmed: 32110396 doi: 10.1177/2049463719857099
Kolacz, J. & Porges, S. W. Chronic diffuse pain and functional gastrointestinal disorders after traumatic stress: pathophysiology through a polyvagal perspective. Front. Med. 5, 145 (2018).
doi: 10.3389/fmed.2018.00145
De Paepe, B., Smet, J., Baeken, C., Van Oosterwijck, J. & Meeus, M. A capital role for the brain’s insula in the diverse fibromyalgia-associated symptoms. Med. Hypotheses 143, 110077 (2020).
pubmed: 32721793 doi: 10.1016/j.mehy.2020.110077
Akiki, T. J., Averill, C. L. & Abdallah, C. G. A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies. Curr. Psychiatry Rep. 19, 81 (2017).
pubmed: 28924828 pmcid: 5960989 doi: 10.1007/s11920-017-0840-4
Häuser, W. et al. Posttraumatic stress disorder in fibromyalgia syndrome: prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome. Pain 154, 1216–1223 (2013).
pubmed: 23685006 doi: 10.1016/j.pain.2013.03.034
Häuser, W., Ablin, J. & Walitt, B. in Comprehensive Guide to Post-Traumatic Stress Disorders (eds Colin, R. M., Victor, R. P., & Vinood, B. P.) 563–577 (Springer International Publishing, 2016).
Crettaz, B. et al. Stress-induced allodynia — evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress. PLoS One 8, e69460 (2013).
pubmed: 23950894 pmcid: 3737255 doi: 10.1371/journal.pone.0069460
Krusemark, E. A., Novak, L. R., Gitelman, D. R. & Li, W. When the sense of smell meets emotion: anxiety-state-dependent olfactory processing and neural circuitry adaptation. J. Neurosci. 33, 15324–15332 (2013).
pubmed: 24068799 pmcid: 3782615 doi: 10.1523/JNEUROSCI.1835-13.2013
Martinez-Lavin, M. & Hermosillo, A. G. Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin. Arthritis Rheum. 29, 197–199 (2000).
pubmed: 10707988 doi: 10.1016/S0049-0172(00)80008-6
Kadetoff, D., Lampa, J., Westman, M., Andersson, M. & Kosek, E. Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels. J. Neuroimmunol. 242, 33–38 (2012).
pubmed: 22126705 doi: 10.1016/j.jneuroim.2011.10.013
Albrecht, D. S. et al. Brain glial activation in fibromyalgia — a multi-site positron emission tomography investigation. Brain Behav. Immun. 75, 72–83 (2018).
pubmed: 30223011 pmcid: 6541932 doi: 10.1016/j.bbi.2018.09.018
Liu, Y. Z., Wang, Y. X. & Jiang, C. L. Inflammation: the common pathway of stress-related diseases. Front. Hum. Neurosci. 11, 316 (2017).
pubmed: 28676747 pmcid: 5476783 doi: 10.3389/fnhum.2017.00316
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J. & Jovanovic, T. Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacology 42, 254–270 (2017).
pubmed: 27510423 doi: 10.1038/npp.2016.146
Troubat, R. et al. Neuroinflammation and depression: a review. Eur. J. Neurosci. 53, 151–171 (2021).
pubmed: 32150310 doi: 10.1111/ejn.14720
Forseth, K. O., Førre, O. & Gran, J. T. A 5.5 year prospective study of self-reported musculoskeletal pain and of fibromyalgia in a female population: significance and natural history. Clin. Rheumatol. 18, 114–121 (1999).
pubmed: 10357115 doi: 10.1007/s100670050067
Holm, L. W., Carroll, L. J., Cassidy, J. D., Skillgate, E. & Ahlbom, A. Widespread pain following whiplash-associated disorders: incidence, course, and risk factors. J. Rheumatol. 34, 193–200 (2007).
pubmed: 17143964
McBeth, J. et al. Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study. Arthritis Rheum. 56, 360–371 (2007).
pubmed: 17195240 doi: 10.1002/art.22336
Tak, L. M., Bakker, S. J. & Rosmalen, J. G. Dysfunction of the hypothalamic-pituitary-adrenal axis and functional somatic symptoms: a longitudinal cohort study in the general population. Psychoneuroendocrinology 34, 869–877 (2009).
pubmed: 19181451 doi: 10.1016/j.psyneuen.2008.12.017
Generaal, E. et al. Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study. Ann. Rheum. Dis. 75, 847–854 (2016).
pubmed: 25902791 doi: 10.1136/annrheumdis-2014-206741
Hung, C. H. et al. Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain. Ann. Rheum. Dis. 79, 1644–1656 (2020).
pubmed: 32907805 doi: 10.1136/annrheumdis-2020-218329
Suarez-Roca, H. et al. Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia. Behav. Brain Res. 167, 205–211 (2006).
pubmed: 16214233 doi: 10.1016/j.bbr.2005.09.006
Pierce, A. N. & Christianson, J. A. Stress and chronic pelvic pain. Prog. Mol. Biol. Transl. Sci. 131, 509–535 (2015).
pubmed: 25744684 doi: 10.1016/bs.pmbts.2014.11.009
Kaplan, C. M. et al. Neurobiological antecedents of multisite pain in children. Pain 163, e596–e603 (2021).
doi: 10.1097/j.pain.0000000000002431
Calhoon, G. G. & Tye, K. M. Resolving the neural circuits of anxiety. Nat. Neurosci. 18, 1394–1404 (2015).
pubmed: 26404714 pmcid: 7575249 doi: 10.1038/nn.4101
Xie, S., Zhang, X., Cheng, W. & Yang, Z. Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults. Gen. Psychiatr. 34, e100411 (2021).
pubmed: 34423252 pmcid: 8340272 doi: 10.1136/gpsych-2020-100411
Abend, R. et al. Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety. Neurobiol. Stress. 16, 100428 (2022).
pubmed: 35036479 pmcid: 8749274 doi: 10.1016/j.ynstr.2022.100428
Clemens, B. et al. Alerted default mode: functional connectivity changes in the aftermath of social stress. Sci. Rep. 7, 40180 (2017).
pubmed: 28054651 pmcid: 5215522 doi: 10.1038/srep40180
Abdallah, C. G. et al. Salience network disruption in U.S. Army soldiers with posttraumatic stress disorder. Chronic Stress 3, 2470547019850467 (2019).
pubmed: 31131337 pmcid: 6529942 doi: 10.1177/2470547019850467
Banks, S. M. & Kerns, R. D. Explaining high rates of depression in chronic pain: a diathesis-stress framework. Psychol. Bull. 119, 95–110 (1996).
doi: 10.1037/0033-2909.119.1.95
Geenen, R., Newman, S., Bossema, E. R., Vriezekolk, J. E. & Boelen, P. A. Psychological interventions for patients with rheumatic diseases and anxiety or depression. Best. Pract. Res. Clin. Rheumatol. 26, 305–319 (2012).
pubmed: 22867928 doi: 10.1016/j.berh.2012.05.004
Choy, E. H. The role of sleep in pain and fibromyalgia. Nat. Rev. Rheumatol. 11, 513–520 (2015).
pubmed: 25907704 doi: 10.1038/nrrheum.2015.56
Creed, F. A review of the incidence and risk factors for fibromyalgia and chronic widespread pain in population-based studies. Pain 161, 1169–1176 (2020).
pubmed: 32040078 doi: 10.1097/j.pain.0000000000001819
Karcher, N. R. & Barch, D. M. The ABCD study: understanding the development of risk for mental and physical health outcomes. Neuropsychopharmacology 46, 131–142 (2021).
pubmed: 32541809 doi: 10.1038/s41386-020-0736-6
Houtveen, J. H., van Eck van der Sluijs, J., Thorsell, S., van Broeckhuysen-Kloth, S. & Geenen, R. Changed dynamic symptom networks after a self-compassion training in patients with somatic symptom disorder: a multiple single-case pilot project. J. Psychosom. Res. 154, 110724 (2022).
pubmed: 35078078 doi: 10.1016/j.jpsychores.2022.110724
Vachon-Presseau, E. et al. Identification of traits and functional connectivity-based neurotraits of chronic pain. PLoS Biol. 17, e3000349 (2019).
pubmed: 31430270 pmcid: 6701751 doi: 10.1371/journal.pbio.3000349
Pace, T. W. et al. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology 34, 87–98 (2009).
pubmed: 18835662 doi: 10.1016/j.psyneuen.2008.08.011
Arch, J. J. et al. Self-compassion training modulates alpha-amylase, heart rate variability, and subjective responses to social evaluative threat in women. Psychoneuroendocrinology 42, 49–58 (2014).
pubmed: 24636501 pmcid: 3985278 doi: 10.1016/j.psyneuen.2013.12.018
Andrés-Rodríguez, L. et al. Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): a randomized, controlled clinical trial. Brain Behav. Immun. 80, 109–119 (2019).
pubmed: 30818032 doi: 10.1016/j.bbi.2019.02.030
Matthewson, G. M., Woo, C. W., Reddan, M. C. & Wager, T. D. Cognitive self-regulation influences pain-related physiology. Pain 160, 2338–2349 (2019).
pubmed: 31145211 doi: 10.1097/j.pain.0000000000001621
Montero-Marin, J. et al. Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: a randomized controlled trial. Sci. Rep. 9, 15639 (2019).
pubmed: 31666651 pmcid: 6821772 doi: 10.1038/s41598-019-52260-z
Maratos, F. A. & Sheffield, D. Brief compassion-focused imagery dampens physiological pain responses. Mindfulness 11, 2730–2740 (2020).
doi: 10.1007/s12671-020-01485-5
Doll, A., Hölzel, B. K., Boucard, C. C., Wohlschläger, A. M. & Sorg, C. Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks. Front. Hum. Neurosci. 9, 461 (2015).
pubmed: 26379526 pmcid: 4548211 doi: 10.3389/fnhum.2015.00461
Cunningham, N. R., Kashikar-Zuck, S. & Coghill, R. C. Brain mechanisms impacted by psychological therapies for pain: identifying targets for optimization of treatment effects. Pain. Rep. 4, e767 (2019).
pubmed: 31579858 pmcid: 6727993 doi: 10.1097/PR9.0000000000000767
Kober, H., Buhle, J., Weber, J., Ochsner, K. N. & Wager, T. D. Let it be: mindful acceptance down-regulates pain and negative emotion. Soc. Cogn. Affect. Neurosci. 14, 1147–1158 (2019).
pubmed: 31989171 doi: 10.1093/scan/nsz104
Scult, M. A. et al. Changes in functional connectivity following treatment with emotion regulation therapy. Front. Behav. Neurosci. 13, 10 (2019).
pubmed: 30778290 pmcid: 6369363 doi: 10.3389/fnbeh.2019.00010
Reddan, M. C. & Wager, T. D. Brain systems at the intersection of chronic pain and self-regulation. Neurosci. Lett. 702, 24–33 (2019).
pubmed: 30503923 doi: 10.1016/j.neulet.2018.11.047
Zeidan, F., Baumgartner, J. N. & Coghill, R. C. The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer. Pain. Rep. 4, e759 (2019).
pubmed: 31579851 pmcid: 6728003 doi: 10.1097/PR9.0000000000000759
Jinich-Diamant, A. et al. Neurophysiological mechanisms supporting mindfulness meditation-based pain relief: an updated review. Curr. Pain. Headache Rep. 24, 56 (2020).
pubmed: 32803491 doi: 10.1007/s11916-020-00890-8
Gentili, C. et al. Psychological flexibility as a resilience factor in individuals with chronic pain. Front. Psychol. 10, 2016 (2019).
pubmed: 31551871 pmcid: 6734029 doi: 10.3389/fpsyg.2019.02016
Conversano, C. et al. Optimism and its impact on mental and physical well-being. Clin. Pract. Epidemiol. Ment. Health 6, 25–29 (2010).
pubmed: 20592964 pmcid: 2894461 doi: 10.2174/1745017901006010025
Purdie, F. & Morley, S. Compassion and chronic pain. Pain 157, 2625–2627 (2016).
pubmed: 27257856 doi: 10.1097/j.pain.0000000000000638
Vallejo, M. A. et al. Self-forgiveness in fibromyalgia patients and its relationship with acceptance, catastrophising and coping. Clin. Exp. Rheumatol. 38, 79–85 (2020).
pubmed: 32116214
Adler-Neal, A. L. & Zeidan, F. Mindfulness meditation for fibromyalgia: mechanistic and clinical considerations. Curr. Rheumatol. Rep. 19, 59 (2017).
pubmed: 28752493 pmcid: 5693231 doi: 10.1007/s11926-017-0686-0
Pinto, A. M., Geenen, R., Castilho, P. & da Silva, J. A. P. Progress towards improved non-pharmacological management of fibromyalgia. Jt. Bone Spine 87, 377–379 (2020).
doi: 10.1016/j.jbspin.2020.02.005
Perrot, S. & Russell, I. J. More ubiquitous effects from non-pharmacologic than from pharmacologic treatments for fibromyalgia syndrome: a meta-analysis examining six core symptoms. Eur. J. Pain. 18, 1067–1080 (2014).
pubmed: 25139817 doi: 10.1002/ejp.564
Veehof, M. M., Trompetter, H. R., Bohlmeijer, E. T. & Schreurs, K. M. Acceptance- and mindfulness-based interventions for the treatment of chronic pain: a meta-analytic review. Cogn. Behav. Ther. 45, 5–31 (2016).
pubmed: 26818413 doi: 10.1080/16506073.2015.1098724
Haugmark, T., Hagen, K. B., Smedslund, G. & Zangi, H. A. Mindfulness- and acceptance-based interventions for patients with fibromyalgia — a systematic review and meta-analyses. PLoS One 14, e0221897 (2019).
pubmed: 31479478 pmcid: 6719827 doi: 10.1371/journal.pone.0221897
Montero-Marin, J. et al. Efficacy of “Attachment-Based Compassion Therapy” in the treatment of fibromyalgia: a randomized controlled trial. Front. Psychiatry 8, 307 (2017).
pubmed: 29387020 doi: 10.3389/fpsyt.2017.00307
Austin, J. et al. Compassion-based interventions for people with long-term physical conditions: a mixed methods systematic review. Psychol. Health 36, 16–42 (2021).
pubmed: 32116052 doi: 10.1080/08870446.2019.1699090
Lumley, M. A. et al. Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster-randomized controlled trial. Pain 158, 2354–2363 (2017).
pubmed: 28796118 pmcid: 5680092 doi: 10.1097/j.pain.0000000000001036
Trindade, I. A., Ferreira, C. & Pinto-Gouveia, J. Acceptability and preliminary test of efficacy of the mind programme in women with breast cancer: an acceptance, mindfulness, and compassion-based intervention. J. Context. Behav. Sci. 15, 162–171 (2020).
doi: 10.1016/j.jcbs.2019.12.005
Carvalho, S. A. et al. Self-compassion in acceptance and commitment therapy for chronic pain: a pilot study. Scand. J. Pain. 22, 631–638 (2021).
pubmed: 34954932 doi: 10.1515/sjpain-2021-0214
Bernardy, K., Klose, P., Welsch, P. & Häuser, W. Efficacy, acceptability and safety of Internet-delivered psychological therapies for fibromyalgia syndrome: a systematic review and meta-analysis of randomized controlled trials. Eur. J. Pain. 23, 3–14 (2019).
pubmed: 29984490 doi: 10.1002/ejp.1284

Auteurs

Ana Margarida Pinto (AM)

University of Coimbra, Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, Coimbra, Portugal.
University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal.
University of Coimbra, Psychological Medicine Institute, Faculty of Medicine, Coimbra, Portugal.

Rinie Geenen (R)

Department of Psychology, Utrecht University, Utrecht, The Netherlands.
Altrecht Psychosomatic Medicine Eikenboom, Zeist, The Netherlands.

Tor D Wager (TD)

Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

Mark A Lumley (MA)

Department of Psychology, Wayne State University, Detroit, MI, USA.

Winfried Häuser (W)

Department Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Munich, Germany.

Eva Kosek (E)

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Jacob N Ablin (JN)

Internal Medicine H, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Kirstine Amris (K)

The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

Jaime Branco (J)

Rheumatology Department, Egas Moniz Hospital - Lisboa Ocidental Hospital Centre (CHLO-EPE), Lisbon, Portugal.
Comprehensive Health Research Center (CHRC), Chronic Diseases Research Centre (CEDOC), NOVA Medical School, NOVA University Lisbon (NMS/UNL), Lisbon, Portugal.

Dan Buskila (D)

Ben Gurion University of the Negev Beer-Sheba, Beersheba, Israel.

João Castelhano (J)

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Coimbra, Portugal.

Miguel Castelo-Branco (M)

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Coimbra, Portugal.

Leslie J Crofford (LJ)

Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Mary-Ann Fitzcharles (MA)

Division of Rheumatology, Department of Medicine, McGill University, Montreal, QC, Canada.

Marina López-Solà (M)

Serra Hunter Programme, Department of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.

Mariana Luís (M)

Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal.

Tiago Reis Marques (TR)

Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital, Imperial College London, London, UK.
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Philip J Mease (PJ)

Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, USA.
University of Washington School of Medicine, Seattle, WA, USA.

Filipe Palavra (F)

Centre for Child Development, Neuropediatric Unit, Paediatric Hospital, Coimbra Hospital and University Centre, Coimbra, Portugal.
University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal.

Jamie L Rhudy (JL)

Department of Psychology, University of Tulsa, Tulsa, OK, USA.

Lucina Q Uddin (LQ)

Department of Psychology, University of Miami, Coral Gables, FL, USA.

Paula Castilho (P)

University of Coimbra, Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, Coimbra, Portugal.

Johannes W G Jacobs (JWG)

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

José A P da Silva (JAP)

University of Coimbra, University Clinic of Rheumatology, Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
Rheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.
University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (i.CBR), Faculty of Medicine, Coimbra, Portugal. jdasilva@chuc.min-saude.pt.

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