Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT.
Humans
Extranodal Extension
Retrospective Studies
Neoplasms, Unknown Primary
/ diagnostic imaging
Prognosis
Oropharyngeal Neoplasms
/ diagnostic imaging
Squamous Cell Carcinoma of Head and Neck
/ diagnostic imaging
Magnetic Resonance Imaging
/ methods
Head and Neck Neoplasms
Positron-Emission Tomography
/ methods
Tomography, X-Ray Computed
/ methods
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
/ methods
Biomarkers
Computed tomography
Extranodal extension
Head and neck cancer
Human papillomavirus
Magnetic resonance imaging
Oropharynx
Positron emission tomography
Squamous cell carcinoma
Unknown primary
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
19
10
2022
accepted:
23
11
2022
pubmed:
6
12
2022
medline:
9
3
2023
entrez:
5
12
2022
Statut:
ppublish
Résumé
The aim of this study was to investigate the value of metabolic tumor imaging using hybrid PET for the preoperative detection of extranodal extension (ENE) in lymph node metastases of oropharyngeal squamous cell carcinoma (OPSCC). We performed a retrospective analysis of a consecutive cohort of patients with OPSCC treated with primary surgery with or without adjuvant (chemo-) radiotherapy at the Kantonsspital Sankt-Gallen and the University Hospital Zurich, Switzerland, from 2010 until 2019. Hybrid PET was compared to conventional cross-sectional imaging with MRI and CT. Histopathological presence of ENE of neck dissection specimen served as gold standard. A total number of 234 patients were included in the study, 95 (40.6%) of which had pathological ENE (pENE). CT has a good specificity with 93.7%; meanwhile, MRI was the most sensitive diagnostic method (72.0%). The nodal metabolic tumor parameters (SUV CT achieved the best specificity, while MRI had the best sensitivity to detect ENE. Nodal metabolic tumor parameters differed significantly between ENE-positive/negative and p16-positive/negative patients. Hence, quantitative data obtained by metabolic imaging might predict presence of ENE and, therefore, could be helpful in customizing therapy management.
Identifiants
pubmed: 36471046
doi: 10.1007/s00405-022-07765-1
pii: 10.1007/s00405-022-07765-1
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1973-1981Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Coskun HH, Medina JE, Robbins KT et al (2015) Current philosophy in the surgical management of neck metastases for head and neck squamous cell carcinoma. Head Neck 37:915–926. https://doi.org/10.1002/hed.23689
doi: 10.1002/hed.23689
pubmed: 24623715
Nichols AC, Theurer J, Prisman E et al (2019) Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial. Lancet Oncol 20:1349–1359. https://doi.org/10.1016/S1470-2045(19)30410-3
doi: 10.1016/S1470-2045(19)30410-3
pubmed: 31416685
Bernier J, Cooper JS, Pajak TF et al (2005) Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 27:843–850. https://doi.org/10.1002/hed.20279
doi: 10.1002/hed.20279
pubmed: 16161069
Blanchard P, Baujat B, Holostenco V et al (2011) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. Radiother Oncol J Eur Soc Ther Radiol Oncol 100:33–40. https://doi.org/10.1016/j.radonc.2011.05.036
doi: 10.1016/j.radonc.2011.05.036
Cooper JS, Zhang Q, Pajak TF et al (2012) Long-term follow-up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 84:1198–1205. https://doi.org/10.1016/j.ijrobp.2012.05.008
doi: 10.1016/j.ijrobp.2012.05.008
pubmed: 22749632
pmcid: 3465463
Caudell JJ, Gillison ML, Maghami E et al (2022) NCCN Guidelines® insights: head and neck cancers, version 1.2022: featured updates to the NCCN guidelines. J Natl Compr Canc Netw 20:224–234. https://doi.org/10.6004/jnccn.2022.0016
doi: 10.6004/jnccn.2022.0016
pubmed: 35276673
Lydiatt W, O’Sullivan B, Patel S (2018) Major changes in head and neck staging for 2018. Am Soc Clin Oncol Educ Book. https://doi.org/10.1200/EDBK_199697
doi: 10.1200/EDBK_199697
pubmed: 30231400
Howard J, Masterson L, Dwivedi RC et al (2016) Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010963.pub2
doi: 10.1002/14651858.CD010963.pub2
pubmed: 27943254
pmcid: 6463943
An Y, Park HS, Kelly JR et al (2017) The prognostic value of extranodal extension in human papillomavirus-associated oropharyngeal squamous cell carcinoma. Cancer 123:2762–2772. https://doi.org/10.1002/cncr.30598
doi: 10.1002/cncr.30598
pubmed: 28323338
Almulla A, Noel CW, Lu L et al (2018) Radiologic-pathologic correlation of extranodal extension in patients with squamous cell carcinoma of the oral cavity: implications for future editions of the TNM classification. Int J Radiat Oncol 102:698–708. https://doi.org/10.1016/j.ijrobp.2018.05.020
doi: 10.1016/j.ijrobp.2018.05.020
Steinkamp HJ, Beck A, Werk M, Felix R (2002) Extracapsular spread of cervical lymph node metastases: diagnostic value of magnetic resonance imaging. ROFO Fortschr Geb Rontgenstr Nuklearmed 174:50–55. https://doi.org/10.1055/s-2002-19533
doi: 10.1055/s-2002-19533
pubmed: 11793284
Steinkamp HJ, van der Hoeck E, Böck JC, Felix R (1999) The extracapsular spread of cervical lymph node metastases: the diagnostic value of computed tomography. ROFO Fortschr Geb Rontgenstr Nuklearmed 170:457–462. https://doi.org/10.1055/s-2007-1011073
doi: 10.1055/s-2007-1011073
pubmed: 10370409
Park SI, Guenette JP, Suh CH et al (2021) The diagnostic performance of CT and MRI for detecting extranodal extension in patients with head and neck squamous cell carcinoma: a systematic review and diagnostic meta-analysis. Eur Radiol 31:2048–2061. https://doi.org/10.1007/s00330-020-07281-y
doi: 10.1007/s00330-020-07281-y
pubmed: 32949282
Toya R, Saito T, Matsuyama T et al (2020) Diagnostic value of FDG-PET/CT for the identification of extranodal extension in patients with head and neck squamous cell carcinoma. Anticancer Res 40:2073–2077. https://doi.org/10.21873/anticanres.14165
doi: 10.21873/anticanres.14165
pubmed: 32234899
Kubicek GJ, Champ C, Fogh S et al (2010) FDG-PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol 2:19. https://doi.org/10.1186/1758-3284-2-19
doi: 10.1186/1758-3284-2-19
pubmed: 20637102
pmcid: 2915991
Gouw ZAR, La Fontaine MD, van Kranen S et al (2019) The Prognostic value of baseline 18F-FDG PET/CT in human papillomavirus-positive versus human papillomavirus-negative patients with oropharyngeal cancer. Clin Nucl Med 44:e323–e328. https://doi.org/10.1097/RLU.0000000000002531
doi: 10.1097/RLU.0000000000002531
pubmed: 30889002
Morand GB, Vital DG, Kudura K et al (2018) Maximum standardized uptake value (SUVmax) of primary tumor predicts occult neck metastasis in oral cancer. Sci Rep 8:11817. https://doi.org/10.1038/s41598-018-30111-7
doi: 10.1038/s41598-018-30111-7
pubmed: 30087375
pmcid: 6081470
Werner J, Hüllner MW, Rupp NJ et al (2019) Predictive value of pretherapeutic maximum standardized uptake value (Suvmax) in laryngeal and hypopharyngeal cancer. Sci Rep 9:8972. https://doi.org/10.1038/s41598-019-45462-y
doi: 10.1038/s41598-019-45462-y
pubmed: 31222167
pmcid: 6586936
Morand GB, Broglie MA, Schumann P et al (2020) Histometabolic tumor imaging of hypoxia in oral cancer: clinicopathological correlation for prediction of an aggressive phenotype. Front Oncol 10:1670. https://doi.org/10.3389/fonc.2020.01670
doi: 10.3389/fonc.2020.01670
pubmed: 32984043
pmcid: 7481376
Sheppard SC, Giger R, Bojaxhiu B et al (2021) Multimodal imaging with positron emission tomography/computed tomography and magnetic resonance imaging to detect extracapsular extension in head and neck cancer. Laryngoscope 131:E163–E169. https://doi.org/10.1002/lary.28602
doi: 10.1002/lary.28602
pubmed: 32142169
Balaker AE, Abemayor E, Elashoff D, St John MA (2012) Cancer of unknown primary: does treatment modality make a difference? Laryngoscope 122:1279–1282. https://doi.org/10.1002/lary.22424
doi: 10.1002/lary.22424
pubmed: 22538837
Huang SH, O’Sullivan B, Su J et al (2020) Prognostic importance of radiologic extranodal extension in HPV-positive oropharyngeal carcinoma and its potential role in refining TNM-8 cN-classification. Radiother Oncol J Eur Soc Ther Radiol Oncol 144:13–22. https://doi.org/10.1016/j.radonc.2019.10.011
doi: 10.1016/j.radonc.2019.10.011
Noor A, Mintz J, Patel S et al (2019) Predictive value of computed tomography in identifying extracapsular spread of cervical lymph node metastases in p16 positive oropharyngeal squamous cell carcinoma. J Med Imaging Radiat Oncol 63:500–509. https://doi.org/10.1111/1754-9485.12888
doi: 10.1111/1754-9485.12888
pubmed: 30973213
Robbins KT, Clayman G, Levine PA et al (2002) Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg 128:751–758. https://doi.org/10.1001/archotol.128.7.751
doi: 10.1001/archotol.128.7.751
pubmed: 12117328
Huellner MW, Appenzeller P, Kuhn FP et al (2014) Whole-body nonenhanced PET/MR versus PET/CT in the staging and restaging of cancers: preliminary observations. Radiology 273:859–869. https://doi.org/10.1148/radiol.14140090
doi: 10.1148/radiol.14140090
pubmed: 25102372
Messerli M, Muehlematter UJ, Fassbind S et al (2021) A pilot study on lung cancer detection based on regional metabolic activity distribution in digital low-dose 18F-FDG PET. Br J Radiol 94:20200244. https://doi.org/10.1259/bjr.20200244
doi: 10.1259/bjr.20200244
pubmed: 33529052
pmcid: 8011269
Freitag J, Wald T, Kuhnt T et al (2020) Extracapsular extension of neck nodes and absence of human papillomavirus 16-DNA are predictors of impaired survival in p16-positive oropharyngeal squamous cell carcinoma. Cancer. https://doi.org/10.1002/cncr.32667
doi: 10.1002/cncr.32667
pubmed: 32503469
pmcid: 7275428
Waech T, Pazahr S, Guarda V et al (2021) Measurement variations of MRI and CT in the assessment of tumor depth of invasion in oral cancer: a retrospective study. Eur J Radiol 135:109480. https://doi.org/10.1016/j.ejrad.2020.109480
doi: 10.1016/j.ejrad.2020.109480
pubmed: 33370639
Faraji F, Aygun N, Coquia SF et al (2020) Computed tomography performance in predicting extranodal extension in HPV-positive oropharynx cancer. Laryngoscope 130:1479–1486. https://doi.org/10.1002/lary.28237
doi: 10.1002/lary.28237
pubmed: 31411751
Stoeckli SJ (2007) Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck. Laryngoscope 117:1539–1551. https://doi.org/10.1097/MLG.0b013e318093ee67
doi: 10.1097/MLG.0b013e318093ee67
pubmed: 17667135
Tirelli G, Tofanelli M, Sacchet E et al (2021) Extranodal extension in head and neck squamous cell cancer: is there a role for further stratification? Br J Oral Maxillofac Surg 59:567–572. https://doi.org/10.1016/j.bjoms.2020.09.015
doi: 10.1016/j.bjoms.2020.09.015
pubmed: 33441284
Gal TJ, O’Brien KJ, Chen Q, Huang B (2020) Clinical vs microscopic extranodal extension and survival in oropharyngeal carcinoma in the human papillomavirus era. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 162:693–701. https://doi.org/10.1177/0194599820910431
doi: 10.1177/0194599820910431
Mermod M, Tolstonog G, Simon C, Monnier Y (2016) Extracapsular spread in head and neck squamous cell carcinoma: a systematic review and meta-analysis. Oral Oncol 62:60–71. https://doi.org/10.1016/j.oraloncology.2016.10.003
doi: 10.1016/j.oraloncology.2016.10.003
pubmed: 27865373
Benchetrit L, Torabi SJ, Givi B et al (2021) Prognostic significance of extranodal extension in HPV-mediated oropharyngeal carcinoma: a systematic review and meta-analysis. Otolaryngol Neck Surg 164:720–732. https://doi.org/10.1177/0194599820951176
doi: 10.1177/0194599820951176
ECOG-ACRIN Cancer Research Group (2022) Phase II randomized trial of transoral surgical resection followed by low-dose or standard-dose IMRT in Resectable p16+ locally advanced oropharynx cancer. clinicaltrials.gov