Double-blinded randomized controlled trial of optimizing nutrition in preterm very low birth weight infants: Bayley scores at 18-38 months of age.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
26
08
2022
accepted:
23
11
2022
revised:
18
11
2022
pubmed:
7
12
2022
medline:
18
1
2023
entrez:
6
12
2022
Statut:
ppublish
Résumé
Human milk supplementation for preterm infants in the neonatal intensive care unit (NICU) can be based on optimized nutrition (feeding adjustments based on growth and measurements of serum nutrients) or individualized nutrition (measurements of macronutrients in mother's own milk). To compare Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at 18-38mo adjusted age in infants who had been randomly allocated to individualized+optimized nutrition (experimental group) vs optimized nutrition alone (control) in the NICU. Double-blinded randomized controlled trial in neonates <29wks gestational age (GA) and those <34wks GA and small for GA. Bayley scores were assessed in 91/114 (80%) infants. The two study groups had similar frequencies of low cognitive, motor and language Bayley scores and similar age-adjusted Bayley scores in bivariate and multivariate analyses. The type of human milk supplementation provided had no significant effect on Bayley scores assessed at 18-38mo. This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
Sections du résumé
BACKGROUND
Human milk supplementation for preterm infants in the neonatal intensive care unit (NICU) can be based on optimized nutrition (feeding adjustments based on growth and measurements of serum nutrients) or individualized nutrition (measurements of macronutrients in mother's own milk).
OBJECTIVE
To compare Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at 18-38mo adjusted age in infants who had been randomly allocated to individualized+optimized nutrition (experimental group) vs optimized nutrition alone (control) in the NICU.
METHODS
Double-blinded randomized controlled trial in neonates <29wks gestational age (GA) and those <34wks GA and small for GA.
RESULTS
Bayley scores were assessed in 91/114 (80%) infants. The two study groups had similar frequencies of low cognitive, motor and language Bayley scores and similar age-adjusted Bayley scores in bivariate and multivariate analyses.
CONCLUSIONS
The type of human milk supplementation provided had no significant effect on Bayley scores assessed at 18-38mo.
TRIAL REGISTRATION
This randomized controlled trial was registered at ClinicalTrials.gov NCT02372136.
Identifiants
pubmed: 36473929
doi: 10.1038/s41372-022-01572-6
pii: 10.1038/s41372-022-01572-6
doi:
Banques de données
ClinicalTrials.gov
['NCT02372136']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-85Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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