A molecular understanding of alphavirus entry and antibody protection.


Journal

Nature reviews. Microbiology
ISSN: 1740-1534
Titre abrégé: Nat Rev Microbiol
Pays: England
ID NLM: 101190261

Informations de publication

Date de publication:
06 2023
Historique:
accepted: 01 11 2022
medline: 18 5 2023
pubmed: 7 12 2022
entrez: 6 12 2022
Statut: ppublish

Résumé

Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human infection and disease on a global scale. These viruses are classified as either arthritogenic or encephalitic based on their genetic relatedness and the clinical syndromes they cause. Although there are currently no approved therapeutics or vaccines against alphaviruses, passive transfer of monoclonal antibodies confers protection in animal models. This Review highlights recent advances in our understanding of the host factors required for alphavirus entry, the mechanisms of action by which protective antibodies inhibit different steps in the alphavirus infection cycle and candidate alphavirus vaccines currently under clinical evaluation that focus on humoral immunity. A comprehensive understanding of alphavirus entry and antibody-mediated protection may inform the development of new classes of countermeasures for these emerging viruses.

Identifiants

pubmed: 36474012
doi: 10.1038/s41579-022-00825-7
pii: 10.1038/s41579-022-00825-7
pmc: PMC9734810
doi:

Substances chimiques

Antibodies, Monoclonal 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

396-407

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI143673
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI164653
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States

Informations de copyright

© 2022. Springer Nature Limited.

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Auteurs

Arthur S Kim (AS)

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Michael S Diamond (MS)

Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. mdiamond@wustl.edu.
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. mdiamond@wustl.edu.
Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA. mdiamond@wustl.edu.
The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA. mdiamond@wustl.edu.

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