Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection.
Distribution
FGF18
Intra-articular
Pharmacokinetics
Rat model
Journal
Osteoarthritis and cartilage open
ISSN: 2665-9131
Titre abrégé: Osteoarthr Cartil Open
Pays: England
ID NLM: 101767068
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
09
04
2020
accepted:
14
04
2020
entrez:
7
12
2022
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
Fibroblast growth factor 18 (FGF18) is involved in chondrogenesis and articular cartilage repair. We investigated tissue distribution and pharmacokinetics of radioactive [ In two studies (48-96-h [n = 23] and 28-day [n = 12]), 35 male albino (Sprague Dawley) rats received single i.v. or i.a. dose [ After i.v. injection, radioactivity peaked in serum and whole blood after 4 and 24 h, respectively, with greater total radioactivity in serum. After i.a. injection, radioactivity peaked in serum and whole blood after 24 and 48 h, respectively; intact [ After i.a. injection of [3H]sprifermin in rats, radioactivity was concentrated in the knee joint, particularly articular cartilage, with low levels in other investigated tissues. Systemic exposure to sprifermin was greater with i.v. than i.a. injection. Subsequent clinical investigation in patients with osteoarthritis has reported consistent results.
Identifiants
pubmed: 36474684
doi: 10.1016/j.ocarto.2020.100068
pii: S2665-9131(20)30057-1
pmc: PMC9718268
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100068Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
C.H. Ladel and H. Guehring are employees of, and shareholders in, Merck KGaA Darmstadt, Germany. L. Barbero is an employee of Merck Serono Ivrea, Colleretto, Italy (an affiliate of Merck KGaA, Darmstadt, Germany). S. Riva is an employee of Gentium s.r.l Villa Guardia, Italy (a company of Jazz Pharmaceuticals).
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