Protocol for the POMELO (Prevention Of MusclE Loss in Osteoarthritis) randomized pilot feasibility trial.
Body composition
Body mass index
Intervention
Obesity
Osteoarthritis
Sarcopenia
Journal
Osteoarthritis and cartilage open
ISSN: 2665-9131
Titre abrégé: Osteoarthr Cartil Open
Pays: England
ID NLM: 101767068
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
06
06
2022
revised:
28
07
2022
accepted:
12
09
2022
entrez:
7
12
2022
pubmed:
8
12
2022
medline:
8
12
2022
Statut:
epublish
Résumé
Individuals with advanced knee osteoarthritis (OA) and a large body size [a body mass index (BMI) ≥35 kg/m This pilot randomized clinical trial compares a 12-week multimodal intervention [including targeted nutrition, progressive resistance exercise, and arthritis self-management support] to usual care. Co-primary outcomes are feasibility and acceptability, with secondary outcomes of change in lean soft tissue and physical function within and between groups at 3-months and 9-months from baseline. Change in waist circumference, fat mass, blood biomarkers, energy metabolism, OA-related pain and function, health-related quality of life, self-efficacy for arthritis management, and interest in pursuing a TKA within and between groups will be explored. This study will inform future development of more personalized knee OA treatment approaches for adults with larger bodies. Further, this will contribute to effective alternative treatment pathways that reduce inequities in access to OA care for this understudied patient population.
Identifiants
pubmed: 36474794
doi: 10.1016/j.ocarto.2022.100312
pii: S2665-9131(22)00080-2
pmc: PMC9718278
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100312Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
All authors declare no competing interests that would create a conflict of interest in connection with this manuscript. KG and MF have no disclosures. CMP has received honoraria and/or paid consultancy from Abbott Nutrition, Nutricia, Nestle Health Science, Fresenius Kabi, and Pfizer, and funding from Almased for research not related to this study.
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