Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.

Humans Mice Animals Chlorides Calcium Pneumonia Lung Cystic Fibrosis Transmembrane Conductance Regulator TRPV Cation Channels

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
07 12 2022
Historique:
entrez: 8 12 2022
pubmed: 9 12 2022
medline: 15 12 2022
Statut: ppublish

Résumé

Pneumonia is the most common cause of the acute respiratory distress syndrome (ARDS). Here, we identified loss of endothelial cystic fibrosis transmembrane conductance regulator (CFTR) as an important pathomechanism leading to lung barrier failure in pneumonia-induced ARDS. CFTR was down-regulated after

Identifiants

DOI: 10.1126/scitranslmed.abg8577 PMID: 36475904
pubmed: 36475904
doi: 10.1126/scitranslmed.abg8577
doi:

Substances chimiques

Chlorides 0
Calcium SY7Q814VUP
CFTR protein, human 0
Cystic Fibrosis Transmembrane Conductance Regulator 126880-72-6
Trpv4 protein, mouse 0
TRPV Cation Channels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabg8577

Auteurs

Lasti Erfinanda (L)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
ORCID: 0000-0003-4974-154X

Lin Zou (L)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
German Heart Center, 13353 Berlin, Germany.
Department of Endocrinology, Shanghai Pudong New Area Gongli Hospital, 200135 Shanghai, China.
ORCID: 0000-0002-0605-6051

Birgitt Gutbier (B)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Laura Kneller (L)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
ORCID: 0000-0002-4463-6831

Sarah Weidenfeld (S)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Laura Michalick (L)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Disi Lei (D)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
German Heart Center, 13353 Berlin, Germany.

Katrin Reppe (K)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Luiz Gustavo Teixeira Alves (LG)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
ORCID: 0000-0002-5822-4168

Bill Schneider (B)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
ORCID: 0000-0003-2991-4474

Qi Zhang (Q)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Caihong Li (C)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Diana Fatykhova (D)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
ORCID: 0000-0003-4474-2025

Paul Schneider (P)

Department for General and Thoracic Surgery, DRK Clinics, 13359 Berlin, Germany.
ORCID: 0000-0002-3274-777X

Wolfgang Liedtke (W)

Departments of Neurology, Neurobiology, and Clinics for Pain and Palliative Care, Duke University Medical Center, Durham, NC 27710, USA.
ORCID: 0000-0003-4166-5394

Eisei Sohara (E)

Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0003-1668-8308

Timothy J Mitchell (TJ)

Institute of Microbiology and Infection, University of Birmingham, Birmingham B15-2TT, UK.
ORCID: 0000-0002-8309-5556

Achim D Gruber (AD)

Institute of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany.
ORCID: 0000-0002-4502-0393

Andreas Hocke (A)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
ORCID: 0000-0002-6935-8612

Stefan Hippenstiel (S)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
ORCID: 0000-0002-5146-1064

Norbert Suttorp (N)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
ORCID: 0000-0002-3958-1151

Andrea Olschewski (A)

Experimental Anaesthesiology, Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, 8010 Graz, Austria.
ORCID: 0000-0002-8189-3634

Marcus A Mall (MA)

German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany.
ORCID: 0000-0002-4057-2199

Martin Witzenrath (M)

Department of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
ORCID: 0000-0002-9787-5633

Wolfgang M Kuebler (WM)

Institute of Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, 10117 Berlin, Germany.
ORCID: 0000-0003-4100-2961

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Appareil respiratoire › Poumon › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Protéines associées à la multirésistance aux médicaments › Protéine CFTR › Loss of endothelial CFTR drives barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Loss of endothelial CFTR drives barrier...