The NAD
D. melanogaster
NAD metabolism
axon degeneration
cell biology
genetics
neurodegeneration
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 12 2022
23 12 2022
Historique:
received:
13
05
2022
accepted:
06
12
2022
pubmed:
9
12
2022
medline:
28
12
2022
entrez:
8
12
2022
Statut:
epublish
Résumé
Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1 in mammals to execute the pathological depletion of the metabolite NAD
Identifiants
pubmed: 36476387
doi: 10.7554/eLife.80245
pii: 80245
pmc: PMC9788811
doi:
pii:
Substances chimiques
Nicotinamide Mononucleotide
1094-61-7
NAD
0U46U6E8UK
SARM1 protein, mouse
0
Cytoskeletal Proteins
0
Armadillo Domain Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S009582/1a
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210904/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201535
Pays : United Kingdom
Informations de copyright
© 2022, Llobet Rosell et al.
Déclaration de conflit d'intérêts
AL, MP, JG, MK, GP, MG, LC, NR, CA, GO, PW, MC, AL, LN No competing interests declared
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