Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease.

Humans Alzheimer Disease Cognitive Reserve Brain Mapping Cognition Brain / diagnostic imaging Cognitive Dysfunction Amyloid beta-Peptides Magnetic Resonance Imaging
Alzheimer's disease Cognitive reserve Default-mode network Functional MRI Lifelong experiences Neural reserve

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
02 2023
Historique:
received: 10 10 2021
revised: 08 04 2022
accepted: 30 05 2022
pubmed: 9 12 2022
medline: 17 1 2023
entrez: 8 12 2022
Statut: ppublish

Résumé

Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.

Identifiants

DOI: 10.1016/j.neurobiolaging.2022.05.015 PMID: 36476760
pubmed: 36476760
pii: S0197-4580(22)00224-X
doi: 10.1016/j.neurobiolaging.2022.05.015
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

33-44

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ersin Ersoezlue (E)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Boris-Stephan Rauchmann (BS)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK.

Thomas Schneider-Axmann (T)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Michael Wagner (M)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Tommaso Ballarini (T)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Maia Tato (M)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Julia Utecht (J)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Carolin Kurz (C)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Boris Papazov (B)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Selim Guersel (S)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Lena Burow (L)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Gabriele Koller (G)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Sophia Stöcklein (S)

Department of Radiology, University Hospital, LMU Munich, Munich, Germany.

Daniel Keeser (D)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Claudia Bartels (C)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany.

Frederic Brosseron (F)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Katharina Buerger (K)

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Arda C Cetindag (AC)

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany.

Peter Dechent (P)

MR-Research in Neurology and Psychiatry, Georg-August-University Göttingen, Germany.

Laura Dobisch (L)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

Michael Ewers (M)

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Klaus Fliessbach (K)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Ingo Frommann (I)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

John D Haynes (JD)

Bernstein Center for Computational Neuroscience, Charité - Universitätsmedizin, Berlin, Germany.

Michael T Heneka (MT)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Daniel Janowitz (D)

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Ingo Kilimann (I)

German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.

Luca Kleinedam (L)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Christoph Laske (C)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Franziska Maier (F)

Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.

Coraline D Metzger (CD)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.

Matthias H Munk (MH)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Oliver Peters (O)

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.

Lukas Preis (L)

German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.

Josef Priller (J)

German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany; Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany.

Alfredo Ramirez (A)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.

Sandra Roeske (S)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Nina Roy (N)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Klaus Scheffler (K)

Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany.

Anja Schneider (A)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Annika Spottke (A)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University of Bonn, Bonn, Germany.

Eike J Spruth (EJ)

Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.

Stefan Teipel (S)

German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.

Jens Wiltfang (J)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.

Steffen Wolfsgruber (S)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany.

Renat Yakupov (R)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

Emrah Duezel (E)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.

Frank Jessen (F)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany.

Robert Perneczky (R)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK; Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK. Electronic address: robert.perneczky@med.lmu.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Réserve cognitive › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Lifelong experiences as a proxy of cognitive...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Lifelong experiences as a proxy of cognitive...