In vitro production of infectious Plasmodium falciparum sporozoites.
Animals
Humans
Mice
Culicidae
/ parasitology
Malaria
/ parasitology
Malaria Vaccines
/ biosynthesis
Malaria, Falciparum
/ parasitology
Plasmodium falciparum
/ growth & development
Sporozoites
/ growth & development
Hepatocytes
/ parasitology
Liver
/ parasitology
Merozoite Surface Protein 1
Erythrocytes
/ parasitology
In Vitro Techniques
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
22
02
2021
accepted:
20
10
2022
pubmed:
9
12
2022
medline:
17
12
2022
entrez:
8
12
2022
Statut:
ppublish
Résumé
An effective vaccine is needed for the prevention and elimination of malaria. The only immunogens that have been shown to have a protective efficacy of more than 90% against human malaria are Plasmodium falciparum (Pf) sporozoites (PfSPZ) manufactured in mosquitoes (mPfSPZ)
Identifiants
pubmed: 36477528
doi: 10.1038/s41586-022-05466-7
pii: 10.1038/s41586-022-05466-7
doi:
Substances chimiques
Malaria Vaccines
0
Merozoite Surface Protein 1
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
534-539Subventions
Organisme : NIAID NIH HHS
ID : R43 AI085740
Pays : United States
Organisme : NIAID NIH HHS
ID : 2R44AI085740-03A1
Pays : United States
Organisme : NIAID NIH HHS
ID : 2R44AI085740-06A1
Pays : United States
Organisme : US Department of Defense
ID : W81XWH-16-2-0025
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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