Dosimetric impact of a robust optimization approach to mitigate effects from rotational uncertainty in prostate intensity-modulated brachytherapy.
high dose-rate brachytherapy
inverse treatment planning
prostate IMBT
robust optimization
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
17
10
2022
received:
17
05
2022
accepted:
01
11
2022
pubmed:
9
12
2022
medline:
18
2
2023
entrez:
8
12
2022
Statut:
ppublish
Résumé
Intensity-modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide an additional degree of freedom, but also introduce an additional, directional, type of uncertainty, compared to conventional high-dose-rate brachytherapy (HDR BT). We propose and evaluate a robust optimization approach to mitigate the effects of rotational uncertainty in the shields with respect to planning criteria. A previously suggested prototype for platinum-shielded prostate We compare dose plans obtained from standard models and their robust counterparts. With dwell times obtained from a linear penalty model (LPM), for 10° errors, the dose to urethra ( We conclude that robust optimization can be used to mitigate the effects from rotational uncertainty and to ensure the treatment plan quality of IMBT.
Sections du résumé
BACKGROUND
BACKGROUND
Intensity-modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide an additional degree of freedom, but also introduce an additional, directional, type of uncertainty, compared to conventional high-dose-rate brachytherapy (HDR BT).
PURPOSE
OBJECTIVE
We propose and evaluate a robust optimization approach to mitigate the effects of rotational uncertainty in the shields with respect to planning criteria.
METHODS
METHODS
A previously suggested prototype for platinum-shielded prostate
RESULTS
RESULTS
We compare dose plans obtained from standard models and their robust counterparts. With dwell times obtained from a linear penalty model (LPM), for 10° errors, the dose to urethra (
CONCLUSIONS
CONCLUSIONS
We conclude that robust optimization can be used to mitigate the effects from rotational uncertainty and to ensure the treatment plan quality of IMBT.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1029-1043Subventions
Organisme : Vetenskapsrådet
ID : VR-NT 2019-05416
Organisme : Cancerfonden
ID : CAN 2017/1029
Organisme : Canada Research Chairs
ID : 252135
Organisme : Collaborative health research projects
ID : 523394-18
Informations de copyright
© 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
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