Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
Coxiella burnetii
Cis-aconitate decarboxylase 1
Immune responsive gene 1
immunometabolism
itaconate
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
08 02 2023
08 02 2023
Historique:
revised:
19
11
2022
received:
22
02
2022
accepted:
22
11
2022
pubmed:
9
12
2022
medline:
10
2
2023
entrez:
8
12
2022
Statut:
ppublish
Résumé
Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication, while other antimicrobial pathways were dispensable. Intratracheal or intraperitoneal infection of Acod1
Identifiants
pubmed: 36479617
doi: 10.15252/emmm.202215931
pmc: PMC9906395
doi:
Substances chimiques
itaconic acid
Q4516562YH
ACOD1 protein, human
EC 4.1.1.-
Irg1 protein, mouse
EC 4.2.1.79
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15931Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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