Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 Dec 2022
08 Dec 2022
Historique:
revised:
12
09
2022
received:
17
05
2022
accepted:
05
10
2022
pmc-release:
08
06
2024
pubmed:
9
12
2022
medline:
9
12
2022
entrez:
8
12
2022
Statut:
aheadofprint
Résumé
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions.
Identifiants
pubmed: 36479795
doi: 10.1002/alz.12845
pmc: PMC10576546
mid: NIHMS1934217
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG043679
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043398
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG054434
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG078362
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062550
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067063
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063857
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054434
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055770
Pays : United States
Organisme : NIA NIH HHS
ID : R21AG056518
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG043679
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG014930
Pays : United States
Organisme : NCCIH NIH HHS
ID : R90 AT008924
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG052350
Pays : United States
Organisme : NIA NIH HHS
ID : R13 AG069386
Pays : United States
Organisme : NIA NIH HHS
ID : RF1AG078362
Pays : United States
Organisme : NIA NIH HHS
ID : RF1AG076124
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060056
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG076124
Pays : United States
Organisme : NIA NIH HHS
ID : R13AG069386
Pays : United States
Organisme : NIA NIH HHS
ID : 2P01AG014930-15A1
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG055770
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS072497
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG067063
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056518
Pays : United States
Informations de copyright
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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