Teaching old drugs new tricks.

Fe-S cluster antibiotics bacteria human mitochondria mitoribosome molecular biophysics ototoxicity structural biology

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
08 Dec 2022
Historique:
entrez: 8 12 2022
pubmed: 9 12 2022
medline: 9 12 2022
Statut: epublish

Résumé

Understanding the mechanism by which streptomycin binds to the small subunit of the mitoribosome may help researchers design less toxic derivatives of this antibiotic.

Identifiants

pubmed: 36480270
doi: 10.7554/eLife.84702
pii: 84702
pmc: PMC9731568
doi:
pii:

Types de publication

Editorial

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/T012412/1
Pays : United Kingdom

Informations de copyright

© 2022, Faille and Warren.

Déclaration de conflit d'intérêts

AF, AW No competing interests declared

Références

Cancer Cell. 2011 Nov 15;20(5):674-88
pubmed: 22094260
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32540971
Elife. 2022 Dec 08;11:
pubmed: 36480258
Brain Res Rev. 2011 Jun 24;67(1-2):311-30
pubmed: 21550666
Nature. 2022 Jun;606(7914):603-608
pubmed: 35676484
Biochem Pharmacol. 2022 Apr;198:114966
pubmed: 35181313
J Otol. 2017 Mar;12(1):1-8
pubmed: 29937831
Cell Metab. 2020 Jun 2;31(6):1078-1090.e5
pubmed: 32386566
Clin Orthop Relat Res. 2005 Aug;(437):3-6
pubmed: 16056018
Cell. 2013 Dec 19;155(7):1624-38
pubmed: 24360282

Auteurs

Alexandre Faille (A)

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

Alan J Warren (AJ)

The Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

Classifications MeSH