Neural precursor cells tune striatal connectivity through the release of IGFBPL1.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 12 2022
08 12 2022
Historique:
received:
23
07
2021
accepted:
30
11
2022
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.
Identifiants
pubmed: 36482070
doi: 10.1038/s41467-022-35341-y
pii: 10.1038/s41467-022-35341-y
pmc: PMC9731988
doi:
Substances chimiques
IGFBPL1 protein, human
0
Insulin-Like Growth Factor Binding Proteins
0
Tumor Suppressor Proteins
0
IGFBPL-1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7579Informations de copyright
© 2022. The Author(s).
Références
Neuropathol Appl Neurobiol. 1999 Jun;25(3):215-25
pubmed: 10417663
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20994-9
pubmed: 19095802
Brain Behav. 2014 Jan;4(1):29-40
pubmed: 24653952
Bioinformatics. 2021 Apr 20;37(3):422-423
pubmed: 32745185
Biol Psychiatry. 2019 Dec 1;86(11):836-847
pubmed: 31471038
Science. 2014 Oct 3;346(6205):89-93
pubmed: 25147279
Rocz Akad Med Bialymst. 1998;43:5-26
pubmed: 9972040
Seizure. 2015 Apr;27:30-9
pubmed: 25891924
Brain. 2015 May;138(Pt 5):1239-46
pubmed: 25823475
Behav Brain Res. 2013 Oct 15;255:44-54
pubmed: 23628212
Mol Cell Neurosci. 2010 Mar;43(3):268-80
pubmed: 19969087
Nat Neurosci. 2008 Oct;11(10):1153-61
pubmed: 18758458
Brain. 2011 Jun;134(Pt 6):1585-7
pubmed: 21616966
Neuroscience. 2017 Mar 6;344:346-359
pubmed: 28057534
Front Neurosci. 2014 Apr 23;8:85
pubmed: 24795559
Nat Neurosci. 2012 Jul 26;15(8):1078-87
pubmed: 22837038
Neuron. 2017 Mar 22;93(6):1451-1463.e4
pubmed: 28334608
Front Neuroanat. 2018 Nov 08;12:91
pubmed: 30467465
Neurol Sci. 2010 Nov;31(Suppl 2):S211-4
pubmed: 20640466
Nat Neurosci. 1999 May;2(5):467-72
pubmed: 10321252
Cell Rep. 2018 Aug 21;24(8):2179-2190.e7
pubmed: 30134177
Biochem Insights. 2019 Apr 17;12:1178626419842176
pubmed: 31024217
Nature. 2020 Aug;584(7820):244-251
pubmed: 32728217
Nat Rev Neurosci. 2001 Oct;2(10):704-16
pubmed: 11584308
Sci Rep. 2018 Feb 1;8(1):2054
pubmed: 29391597
Brain. 2007 Oct;130(Pt 10):2543-53
pubmed: 17626034
Ann Neurol. 1982 Jun;11(6):599-607
pubmed: 7114809
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Jul;27(4):581-594
pubmed: 31411534
Cell Rep. 2019 Jan 8;26(2):394-406.e5
pubmed: 30625322
CNS Drugs. 2018 Jun;32(6):543-558
pubmed: 29926371
Biophys J. 1994 Jan;66(1):259-67
pubmed: 8130344
Science. 2004 Jun 25;304(5679):1926-9
pubmed: 15218136
Nature. 2003 Apr 17;422(6933):688-94
pubmed: 12700753
Genome Biol. 2018 Feb 6;19(1):15
pubmed: 29409532
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Cell. 2016 Jul 28;166(3):703-715
pubmed: 27453468
J Neurosci. 2016 Feb 03;36(5):1647-59
pubmed: 26843646
Mult Scler. 2017 Apr;23(5):721-733
pubmed: 28206827
Nat Commun. 2017 Oct 31;8(1):1229
pubmed: 29089485
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Neurosci. 2005 Nov 23;25(47):10884-93
pubmed: 16306401
Neuron. 2016 Oct 5;92(1):84-92
pubmed: 27710792
Nat Rev Neurosci. 2006 May;7(5):395-406
pubmed: 16760919
Nat Methods. 2019 Dec;16(12):1289-1296
pubmed: 31740819
J Neurosci. 2019 Jul 10;39(28):5481-5492
pubmed: 31138656
Stem Cells Dev. 2012 Jul 20;21(11):1831-7
pubmed: 22122665
J Neurosci. 2008 May 21;28(21):5504-12
pubmed: 18495884
Neuroimage. 2017 May 15;152:450-466
pubmed: 28284799
Neuron. 2010 Aug 12;67(3):466-79
pubmed: 20696383
J Clin Invest. 2014 Mar;124(3):1228-41
pubmed: 24569378
Brain. 2012 Nov;135(Pt 11):3320-35
pubmed: 23008234
Mult Scler Relat Disord. 2019 Jun;31:93-96
pubmed: 30953954
Mov Disord. 1996 Mar;11(2):136-42
pubmed: 8684382
Nat Rev Neurosci. 2019 Aug;20(8):482-494
pubmed: 31171839
J Neurosci. 2005 May 11;25(19):4801-5
pubmed: 15888655
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Nat Neurosci. 2005 Sep;8(9):1179-87
pubmed: 16116450
Nat Neurosci. 2012 Nov;15(11):1485-7
pubmed: 23086334
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Harv Rev Psychiatry. 2017 Nov/Dec;25(6):270-278
pubmed: 29117022
Cell Syst. 2019 Apr 24;8(4):281-291.e9
pubmed: 30954476
Ann Neurol. 2019 Mar;85(3):340-351
pubmed: 30719730
J Neurol Sci. 2006 Jun 15;245(1-2):41-6
pubmed: 16643953
Cell. 2013 Jun 6;153(6):1219-1227
pubmed: 23746839
J Neurosci. 2009 Apr 15;29(15):5032-43
pubmed: 19369572
Genome Res. 2012 Sep;22(9):1760-74
pubmed: 22955987
Nat Rev Neurosci. 2001 Apr;2(4):229-39
pubmed: 11283746
Nat Cell Biol. 2011 Jul 31;13(9):1076-83
pubmed: 21804544
Mult Scler. 2006 Dec;12(6):787-93
pubmed: 17263008
Nat Rev Neurosci. 2010 May;11(5):316-28
pubmed: 20404840
Neurosci Lett. 2010 Jan 22;469(2):214-8
pubmed: 19962428
Genome Res. 2017 Mar;27(3):491-499
pubmed: 28100584
Neuroimage. 2017 Jul 15;155:159-168
pubmed: 28435096
Brain Res. 1997 Sep 19;769(1):97-107
pubmed: 9374277
Brain Res. 2020 Mar 1;1730:146619
pubmed: 31874148
Cell. 1999 Jun 11;97(6):703-16
pubmed: 10380923
J Clin Invest. 2014 Mar;124(3):970-3
pubmed: 24569367
Circ Res. 2019 Feb 15;124(4):511-525
pubmed: 30591003
J Int Neuropsychol Soc. 2015 Mar;21(3):193-202
pubmed: 25850430
Brain. 2008 Oct;131(Pt 10):2564-78
pubmed: 18757884
EMBO J. 2019 Mar 15;38(6):
pubmed: 30643018
PLoS Biol. 2015 Jan 26;13(1):e1002045
pubmed: 25621867
J Anat. 1953 Oct;87(4):387-406
pubmed: 13117757
Cell Stem Cell. 2008 Sep 11;3(3):279-88
pubmed: 18786415
Front Neurosci. 2016 Feb 23;10:52
pubmed: 26941597
Trends Neurosci. 2003 Aug;26(8):436-43
pubmed: 12900175
Neuron. 1999 Jun;23(2):399-409
pubmed: 10399944
Nature. 2004 Feb 19;427(6976):740-4
pubmed: 14973487
Science. 2019 Nov 29;366(6469):1134-1139
pubmed: 31727856
Neuron. 2016 Jul 20;91(2):260-92
pubmed: 27477017
Cell. 2017 Nov 16;171(5):1191-1205.e28
pubmed: 29149606
Nat Biotechnol. 2022 Feb;40(2):235-244
pubmed: 34635836