Non-invasive diagnostic method to objectively measure olfaction and diagnose smell disorders by molecularly targeted fluorescent imaging agent.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
29 Nov 2022
Historique:
pubmed: 10 12 2022
medline: 10 12 2022
entrez: 9 12 2022
Statut: epublish

Résumé

The sense of smell (olfaction) is one of the most important senses for animals including humans. Despite significant advances in the understanding mechanism of olfaction, currently, there are no objective non-invasive methods that can identify loss of smell. Covid-19-related loss of smell has highlighted the need to develop methods that can identify loss of olfaction. Voltage-gated sodium channel 1.7 (Na

Identifiants

DOI: 10.1101/2021.10.07.463532 PMID: 36482968 PMC: PMC9727758
pubmed: 36482968
doi: 10.1101/2021.10.07.463532
pmc: PMC9727758
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIDCD NIH HHS
ID : K23 DC019678
Pays : United States

Déclaration de conflit d'intérêts

Disclosure of Potential Conflicts of Interest S.P. and T.R. are shareholders of Summit Biomedical Imaging, T.R. is now an executive of and shareholder in Novartis AG. J.G., P.D.S.F., G.K. and T.R. are co-inventors on a Tsp1a-related patent application. All other authors have no conflicts to declare.

Auteurs

Dauren Adilbay (D)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Junior Gonzales (J)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Marianna Zazhytska (M)

Mortimer B. Zuckerman Mind, Brain and Behavior Institute, Columbia University, New York, NY 10027, USA.

Paula Demetrio de Souza Franca (P)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Sheryl Roberts (S)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tara Viray (T)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Raik Artschwager (R)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Snehal Patel (S)

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Albana Kodra (A)

Mortimer B. Zuckerman Mind, Brain and Behavior Institute, Columbia University, New York, NY 10027, USA.
Department of Genetics and Development, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

Jonathan B Overdevest (JB)

Department of Otolaryngology- Head and Neck Surgery, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

Chun Yuen Chow (CY)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St Lucia, QLD 4072, Australia.

Glenn F King (GF)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St Lucia, QLD 4072, Australia.

Sanjay K Jain (SK)

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alvaro A Ordonez (AA)

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Laurence S Carroll (LS)

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Thomas Reiner (T)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiology, Weill Cornell Medical College, New York, NY, USA.
Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nagavarakishore Pillarsetty (N)

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiology, Weill Cornell Medical College, New York, NY, USA.
Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Classifications MeSH