Lupus Nephritis: Current Perspectives and Moving Forward.
autoimmunity
glomerulonephritis
proteinuria
steroids
systemic lupus erythematosus
Journal
Journal of inflammation research
ISSN: 1178-7031
Titre abrégé: J Inflamm Res
Pays: New Zealand
ID NLM: 101512684
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
10
2022
accepted:
22
11
2022
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
10
12
2022
Statut:
epublish
Résumé
Lupus nephritis is a severe organ manifestation of systemic lupus erythematosus, and its pathogenesis involves complex etiology and mechanisms. Despite significant knowledge gains and extensive efforts put into understanding the development and relapsing disease activity, lupus nephritis remains a substantial cause of morbidity and mortality in lupus patients. Current therapies retain a significant unmet medical need regarding rates of complete response, preventing relapse of lupus nephritis, progression of chronic kidney disease to kidney failure, drug toxicity, and pill burden-related drug non-adherence. Connected to progression of chronic kidney disease are the associated risks for disabling or even lethal cardiovascular events, as well as chronic kidney disease-related secondary immunodeficiency and serious infections. In this regard, biomarkers are needed that can predict treatment response to specific drugs to enable personalized precision medicine. A series of clinical trials with innovative immunomodulatory drugs are ongoing and raise expectations for improvements in the management of lupus nephritis. Here, we review how new developments in pathogenesis connect with current and future perspectives for the management of lupus nephritis.
Identifiants
pubmed: 36483271
doi: 10.2147/JIR.S363722
pii: 363722
pmc: PMC9726217
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
6533-6552Informations de copyright
© 2022 Lichtnekert et al.
Déclaration de conflit d'intérêts
HJA received honoraries from GSK, Novartis, Janssen, Otsuka, Kezar, and AstraZeneca. He also reports grants and/or personal fees from Bayer, Boehringer Ingelheim, Previpharma, and Lilly. The authors report no other conflicts of interest in this work.
Références
Ann Rheum Dis. 2015 Jul;74(7):1474-8
pubmed: 25710470
Immunol Rev. 2001 Apr;180:100-11
pubmed: 11414352
Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii56-61
pubmed: 23253915
Arthritis Res Ther. 2014 May 21;16(3):R114
pubmed: 24886912
Clin Kidney J. 2016 Aug;9(4):552-5
pubmed: 27478595
Curr Opin Rheumatol. 2022 Mar 1;34(2):125-132
pubmed: 34939607
Immunol Rev. 2016 Nov;274(1):218-232
pubmed: 27782329
Arthritis Rheumatol. 2018 Feb;70(2):266-276
pubmed: 29073347
Lupus. 2013 Jan;22(1):63-72
pubmed: 23263865
J Immunol Res. 2019 Dec 1;2019:3638562
pubmed: 31871956
Nat Rev Rheumatol. 2010 Dec;6(12):683-92
pubmed: 21060334
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
pubmed: 26371324
Genomics. 1998 Jul 1;51(1):124-7
pubmed: 9693040
Ann Rheum Dis. 2016 Feb;75(2):323-31
pubmed: 26338095
BMC Res Notes. 2021 Dec 18;14(1):455
pubmed: 34922596
Clin Immunol. 2017 Dec;185:59-73
pubmed: 27519955
J Transl Autoimmun. 2019 Dec 17;3:100029
pubmed: 32743514
Nature. 2004 Dec 23;432(7020):1032-6
pubmed: 15525940
Ann Rheum Dis. 2016 Feb;75(2):332-40
pubmed: 26293163
Lupus. 2005;14(6):417-22
pubmed: 16038103
Lupus. 2010 Oct;19(11):1281-9
pubmed: 20605876
Clin Exp Immunol. 2006 Feb;143(2):274-80
pubmed: 16412051
Ann Rheum Dis. 2022 Jan;81(1):100-107
pubmed: 34615636
Lancet. 2021 May 29;397(10289):2070-2080
pubmed: 33971155
Orphanet J Rare Dis. 2013 Jan 07;8:2
pubmed: 23289717
J Am Soc Nephrol. 2009 Apr;20(4):901-11
pubmed: 19297556
Kidney Dis (Basel). 2015 Sep;1(2):91-9
pubmed: 27536669
Arthritis Res Ther. 2010;12(5):R174
pubmed: 20849588
J Am Soc Nephrol. 2008 Oct;19(10):2001-10
pubmed: 18596121
Expert Opin Pharmacother. 2018 Oct;19(14):1613-1621
pubmed: 30207816
J Clin Med. 2020 Mar 05;9(3):
pubmed: 32151092
Nat Med. 2022 Oct;28(10):2124-2132
pubmed: 36109639
PLoS One. 2013 Dec 27;8(12):e84450
pubmed: 24386384
Immunity. 2016 Aug 16;45(2):227-8
pubmed: 27533006
Science. 2006 Jun 16;312(5780):1669-72
pubmed: 16709748
Lancet. 2018 Jul 21;392(10143):222-231
pubmed: 30043749
Clin Sci (Lond). 2019 Aug 5;133(15):1721-1744
pubmed: 31358596
N Engl J Med. 2020 Sep 17;383(12):1149-1155
pubmed: 32937047
Curr Rheumatol Rep. 2016 Dec;18(12):73
pubmed: 27812954
Blood. 2005 May 15;105(10):3965-71
pubmed: 15687242
J Am Soc Nephrol. 2013 Nov;24(11):1743-54
pubmed: 23970121
Nat Rev Nephrol. 2022 Jul;18(7):415-416
pubmed: 35523957
Kidney Int Rep. 2021 Dec 14;7(3):516-525
pubmed: 35257064
Clin Exp Immunol. 2006 Oct;146(1):133-45
pubmed: 16968408
Blood. 2010 Jun 3;115(22):4393-402
pubmed: 20194898
Curr Rheumatol Rep. 2013 Sep;15(9):369
pubmed: 23943494
Arthritis Rheumatol. 2014 Feb;66(2):390-6
pubmed: 24504811
J Immunol. 2012 Feb 15;188(4):1578-81
pubmed: 22250083
J Am Soc Nephrol. 2005 Nov;16(11):3273-80
pubmed: 16176997
Lancet. 2018 Mar 24;391(10126):1186-1196
pubmed: 29551338
J Am Soc Nephrol. 2010 Sep;21(9):1422-6
pubmed: 20688934
Nat Genet. 2009 Nov;41(11):1228-33
pubmed: 19838195
Ann Rheum Dis. 2022 Apr 27;:
pubmed: 35477518
RMD Open. 2020 Dec;6(3):
pubmed: 33380521
Am J Kidney Dis. 2011 Feb;57(2):235-44
pubmed: 21177013
PLoS One. 2018 Jun 28;13(6):e0199003
pubmed: 29953444
Arthritis Res Ther. 2020 Apr 25;22(1):93
pubmed: 32334614
Ann Rheum Dis. 2011 Dec;70(12):2207-17
pubmed: 21875872
PLoS One. 2012;7(9):e45356
pubmed: 23049788
J Immunol. 2005 Sep 1;175(5):2851-8
pubmed: 16116171
Genes Immun. 2013 Dec;14(8):471-8
pubmed: 23965942
Nat Med. 2008 Jul;14(7):748-55
pubmed: 18542049
J Biol Chem. 2011 May 13;286(19):17303-10
pubmed: 21454473
Lupus. 2018 May;27(6):1007-1011
pubmed: 29448881
Expert Rev Clin Immunol. 2019 Jun;15(6):629-637
pubmed: 30874446
N Engl J Med. 2021 Aug 5;385(6):567-569
pubmed: 34347960
Rheumatology (Oxford). 2022 Aug 30;61(9):3830-3840
pubmed: 35040950
Curr Opin Rheumatol. 2008 Sep;20(5):538-44
pubmed: 18698174
J Exp Med. 2004 Jun 7;199(11):1577-84
pubmed: 15173206
N Engl J Med. 2022 Mar 17;386(11):1034-1045
pubmed: 35294813
Ann Rheum Dis. 2011 Jul;70(7):1330-7
pubmed: 21622776
Ann Rheum Dis. 2018 Jun;77(6):883-889
pubmed: 29563108
Nat Genet. 2008 Feb;40(2):204-10
pubmed: 18204446
Blood. 2005 Feb 15;105(4):1614-21
pubmed: 15507523
Autoimmun Rev. 2012 Dec;12(2):174-94
pubmed: 22982174
Nephrol Dial Transplant. 2012 Apr;27(4):1467-72
pubmed: 21917733
Ann Rheum Dis. 2021 Jan;80(1):14-25
pubmed: 33051219
Ann Intern Med. 2015 Jan 6;162(1):18-26
pubmed: 25383558
Ann Rheum Dis. 2020 Jan;79(1):141-149
pubmed: 31537547
Nature. 2022 May;605(7909):349-356
pubmed: 35477763
Immunity. 2006 Sep;25(3):417-28
pubmed: 16973389
Am J Transplant. 2013 Jun;13(6):1503-11
pubmed: 23570303
Arthritis Res Ther. 2012 May 29;14(3):211
pubmed: 22640752
Nat Genet. 2008 Sep;40(9):1062-4
pubmed: 19165919
Mol Immunol. 2015 Sep;67(1):3-11
pubmed: 25846716
Ann Rheum Dis. 2012 Nov;71(11):1809-14
pubmed: 22523428
Ann Rheum Dis. 2022 Apr;81(4):496-506
pubmed: 35144924
Semin Immunopathol. 2014 Jul;36(4):443-59
pubmed: 24402709
J Clin Med. 2021 Feb 07;10(4):
pubmed: 33562189
Arthritis Rheumatol. 2019 Sep;71(9):1400-1412
pubmed: 31385462
Front Genet. 2020 Jul 03;11:600
pubmed: 32719713
J Leukoc Biol. 2004 Jun;75(6):1022-8
pubmed: 15020647
Arthritis Res Ther. 2013;15 Suppl 1:S3
pubmed: 23566754
Autoimmun Rev. 2010 May;9(7):473-6
pubmed: 20144911
Dis Model Mech. 2021 Mar 18;14(3):
pubmed: 33737335
Front Immunol. 2022 Aug 24;13:953439
pubmed: 36090990
BMC Immunol. 2015 Feb 12;16:6
pubmed: 25879435
Rheumatology (Oxford). 2022 Aug 3;61(8):3329-3340
pubmed: 34897375
Clin Immunol. 2017 Dec;185:86-94
pubmed: 27423476
Nat Med. 2008 Sep;14(9):931-8
pubmed: 18724379
Trends Immunol. 2011 Dec;32(12):574-81
pubmed: 21940216
Genes Immun. 2012 Apr;13(3):232-8
pubmed: 22189356
J Exp Med. 2010 Dec 20;207(13):2959-73
pubmed: 21115689
Genes Immun. 2021 Jul;22(3):194-202
pubmed: 34127828
Immunity. 2007 Nov;27(5):801-10
pubmed: 17997333
Nat Commun. 2021 Jun 7;12(1):3391
pubmed: 34099646
PLoS Genet. 2011 Mar;7(3):e1001323
pubmed: 21408207
Arthritis Rheumatol. 2017 Jan;69(1):148-160
pubmed: 27429362
Am J Med Sci. 2013 Oct;346(4):319-23
pubmed: 23370533
Nat Rev Dis Primers. 2020 Jan 23;6(1):7
pubmed: 31974366
Nat Genet. 2008 Feb;40(2):152-4
pubmed: 18204448
Ann Rheum Dis. 2016 Jan;75(1):30-6
pubmed: 25550339
Immunol Today. 1994 Sep;15(9):432-6
pubmed: 7524520
Ann Rheum Dis. 2016 Nov;75(11):1909-1916
pubmed: 27009916
Clin Exp Rheumatol. 2022 Sep;40(9):1708-1717
pubmed: 35084314
Nat Immunol. 2017 Feb;18(2):196-204
pubmed: 27941787
Am J Hum Genet. 2013 Jan 10;92(1):41-51
pubmed: 23273568
J Autoimmun. 2010 May;34(3):J276-86
pubmed: 20005073
Clin Dev Immunol. 2012;2012:604892
pubmed: 22690240
Lupus. 2008 Apr;17(4):305-13
pubmed: 18413412
JAMA Netw Open. 2022 Mar 1;5(3):e224492
pubmed: 35353167
PLoS Genet. 2008 May 30;4(5):e1000084
pubmed: 18516230
Ann Rheum Dis. 2016 Jan;75(1):196-202
pubmed: 26038091
Cell. 2016 Apr 21;165(3):551-65
pubmed: 27040498
Ups J Med Sci. 2011 Nov;116(4):227-37
pubmed: 22066971
Z Rheumatol. 2015 Feb;74(1):20-5
pubmed: 25616773
Viral Immunol. 2018 Sep;31(7):537-538
pubmed: 29883277
Immunity. 2011 May 27;34(5):680-92
pubmed: 21616437
J Exp Med. 2017 May 1;214(5):1547-1555
pubmed: 28420733
J Am Soc Nephrol. 2013 Sep;24(9):1357-66
pubmed: 23929771
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006
pubmed: 22011580
Arthritis Rheum. 2012 Apr;64(4):1215-26
pubmed: 22231479
Nat Immunol. 2020 Sep;21(9):1094-1106
pubmed: 32747814
Curr Opin Immunol. 2016 Dec;43:32-38
pubmed: 27636649
J Am Soc Nephrol. 2022 Feb;33(2):259-278
pubmed: 34907031
Ann Rheum Dis. 2020 Aug;79(8):1070-1076
pubmed: 32448782
Arthritis Rheumatol. 2018 Jul;70(7):1071-1076
pubmed: 29513931
Biomed Res Int. 2013;2013:597921
pubmed: 23936824
Arthritis Rheum. 2010 Jan;62(1):222-33
pubmed: 20039413
Cytokine Growth Factor Rev. 2018 Apr;40:48-58
pubmed: 29625900
J Am Soc Nephrol. 2017 Dec;28(12):3671-3678
pubmed: 28760751