Predictors of bowel damage in the long-term progression of Crohn's disease.
Bowel damage
Crohn’s disease
Inflammatory bowel disease
Lémann index
Magnetic resonance imaging
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
26 Nov 2022
26 Nov 2022
Historique:
received:
14
09
2022
revised:
06
10
2022
accepted:
31
10
2022
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
10
12
2022
Statut:
ppublish
Résumé
Crohn's disease (CD) is a chronic inflammatory bowel disorder that progresses to bowel damage (BD) over time. An image-based index, the Lémann index (LI), has been developed to measure cumulative BD. To characterize the long-term progression of BD in CD based on changes in the LI and to determine risk factors for long-term progression. This was a single-center longitudinal cohort study. Patients who had participated in prospective studies on the accuracy of magnetic resonance imaging using endoscopy as a gold standard and who had a follow-up of at least 5 years were re-evaluated after 5-12 years. Seventy-two patients were included. LI increased in 38 patients (52.8%), remained unchanged in 9 patients (12.5%), and decreased in 25 patients (34.7%). The small bowel score and surgery subscale significantly increased ( BD, as assessed by the LI, progressed in half of the patients with CD over a period of 5-12 years. The main determinants of BD progression were ileal location, stricturing/fistulizing phenotype, and disease duration.
Sections du résumé
BACKGROUND
BACKGROUND
Crohn's disease (CD) is a chronic inflammatory bowel disorder that progresses to bowel damage (BD) over time. An image-based index, the Lémann index (LI), has been developed to measure cumulative BD.
AIM
OBJECTIVE
To characterize the long-term progression of BD in CD based on changes in the LI and to determine risk factors for long-term progression.
METHODS
METHODS
This was a single-center longitudinal cohort study. Patients who had participated in prospective studies on the accuracy of magnetic resonance imaging using endoscopy as a gold standard and who had a follow-up of at least 5 years were re-evaluated after 5-12 years.
RESULTS
RESULTS
Seventy-two patients were included. LI increased in 38 patients (52.8%), remained unchanged in 9 patients (12.5%), and decreased in 25 patients (34.7%). The small bowel score and surgery subscale significantly increased (
CONCLUSION
CONCLUSIONS
BD, as assessed by the LI, progressed in half of the patients with CD over a period of 5-12 years. The main determinants of BD progression were ileal location, stricturing/fistulizing phenotype, and disease duration.
Identifiants
pubmed: 36483818
doi: 10.12998/wjcc.v10.i33.12208
pmc: PMC9724529
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12208-12220Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Dr. Rimola reports grants from Abbvie, personal fees from Alimentiv, personal fees from Janssen, personal fees from Takeda, non-financial support from Gilead and from Agumab during the conduct of the study.
Références
Gastroenterology. 2015 Jan;148(1):52-63.e3
pubmed: 25241327
United European Gastroenterol J. 2020 May;8(4):410-417
pubmed: 32213030
Aliment Pharmacol Ther. 2020 May;51(9):889-898
pubmed: 32221985
Aliment Pharmacol Ther. 2020 Nov;52(10):1563-1573
pubmed: 32886809
Open Med (Wars). 2019 Nov 07;14:785-791
pubmed: 31737782
Gastroenterology. 2021 Sep;161(3):853-864.e13
pubmed: 34052277
Clin Gastroenterol Hepatol. 2015 Sep;13(9):1633-40.e3
pubmed: 25766650
Clin Gastroenterol Hepatol. 2018 Jan;16(1):75-82.e5
pubmed: 28694130
Scand J Gastroenterol. 2019 Nov;54(11):1339-1345
pubmed: 31692395
Dig Liver Dis. 2017 May;49(5):490-494
pubmed: 28233685
Gut. 2015 Sep;64(9):1397-402
pubmed: 25516418
Gastroenterology. 2010 Oct;139(4):1147-55
pubmed: 20637205
J Crohns Colitis. 2015 Aug;9(8):633-9
pubmed: 25958059
Dig Liver Dis. 2017 Feb;49(2):175-180
pubmed: 27864028
J Crohns Colitis. 2010 Feb;4(1):7-27
pubmed: 21122488