Clarifying the Ethics and Oversight of Chimeric Research.
animal research
bioethics
chimeras
human dignity
oversight
public communication
stem cells
Journal
The Hastings Center report
ISSN: 1552-146X
Titre abrégé: Hastings Cent Rep
Pays: United States
ID NLM: 0410447
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
15
12
2022
Statut:
ppublish
Résumé
This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human-nonhuman chimeric research. Led by bioethics researchers working closely with an interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human-nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics' previous focus on human-centered questions about the ethics of "humanization" and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less-siloed governance and oversight and more-comprehensive public communication.
Identifiants
pubmed: 36484509
doi: 10.1002/hast.1427
pmc: PMC9911087
mid: NIHMS1847141
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S2-S23Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG010168
Pays : United States
Organisme : National Human Genome Research Institute of the National Institutes of Health
ID : R01HG010168
Informations de copyright
© 2022 The Hastings Center.
Références
Biochem Pharmacol. 2014 Jan 1;87(1):162-71
pubmed: 23954708
Lancet Psychiatry. 2020 Mar;7(3):272-281
pubmed: 31704113
Kennedy Inst Ethics J. 2005 Jun;15(2):107-34
pubmed: 16149204
Kennedy Inst Ethics J. 2005 Dec;15(4):347-70
pubmed: 16453949
Berkeley Technol Law J. 1999;14:443-60
pubmed: 15732205
Science. 2019 Aug 30;365(6456):
pubmed: 31467194
Cell Stem Cell. 2014 Oct 2;15(4):406-409
pubmed: 25280216
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3585-6
pubmed: 25805804
Cell. 2017 Jan 26;168(3):473-486.e15
pubmed: 28129541
Kennedy Inst Ethics J. 2008 Dec;18(4):331-46
pubmed: 19143408
Nature. 2016 May 04;533(7602):169-71
pubmed: 27172031
Stem Cells. 2019 Apr;37(4):444-452
pubmed: 30629789
Camb Q Healthc Ethics. 2020 Jan;29(1):19-37
pubmed: 31581963
ALTEX. 2013;30(3):275-91
pubmed: 23861075
Stem Cells Dev. 2015 Jan 15;24(2):182-9
pubmed: 25192056
Stem Cell Reports. 2020 Oct 13;15(4):804-810
pubmed: 33007202
Am J Bioeth. 2014;14(2):4-12
pubmed: 24521325
US Statut Large. 1985;99(Title IV Sections 1-12):Unknown
pubmed: 11686169
PLoS One. 2009 Nov 30;4(11):e7824
pubmed: 19956596
Science. 1998 Nov 6;282(5391):1145-7
pubmed: 9804556
Cell. 2021 Apr 15;184(8):2020-2032.e14
pubmed: 33861963
Cell Stem Cell. 2021 Dec 2;28(12):2047-2061.e5
pubmed: 34861146
Nature. 2018 Mar 22;555(7697):428-430
pubmed: 29565377
Nature. 2016 Feb 4;530(7588):98-102
pubmed: 26808898
Am J Bioeth. 2003 Summer;3(3):1-13
pubmed: 14594461
Hastings Cent Rep. 2015 Mar-Apr;45(2):27-39
pubmed: 25628068
Animals (Basel). 2021 Feb 02;11(2):
pubmed: 33540590
Am J Bioeth. 2003 Summer;3(3):W6-W8
pubmed: 14594463
ILAR J. 2019 Dec 31;60(1):17-23
pubmed: 31687758
Boston Coll Law Rev. 2004 May;45(3):619-66
pubmed: 16514749
Cell Stem Cell. 2016 Aug 4;19(2):152-153
pubmed: 27494672
Reprod Domest Anim. 2016 Oct;51 Suppl 2:18-24
pubmed: 27762052
Trends Biotechnol. 2020 Apr;38(4):351-354
pubmed: 32014274
Cell Stem Cell. 2013 Mar 7;12(3):342-53
pubmed: 23472873
Xenotransplantation. 2017 Jul;24(4):
pubmed: 28677148
PLoS Biol. 2010 Mar 30;8(3):e1000344
pubmed: 20361022
Cell Stem Cell. 2007 Sep 13;1(3):259-62
pubmed: 18371360
Stem Cell Reports. 2021 Feb 9;16(2):225-226
pubmed: 33567291
N Engl J Med. 2006 Oct 19;355(16):1730-5
pubmed: 17050899
Stem Cell Reports. 2021 Jun 8;16(6):1409-1415
pubmed: 34048695
Methods Mol Biol. 2019;2005:221-231
pubmed: 31175656
Lab Anim (NY). 2018 Mar;47(3):57-58
pubmed: 29483693
Nature. 2021 Jul;595(7869):633-634
pubmed: 34267388
Cell Stem Cell. 2007 Aug 16;1(2):159-63
pubmed: 18383627
Bioethics. 2021 Jan;35(1):98-104
pubmed: 32783224
Am J Bioeth. 2007 May;7(5):27-40
pubmed: 17497502
Nature. 2016 Dec 1;540(7631):51-59
pubmed: 27905428
Stem Cells Dev. 2020 Jul 1;29(13):807-810
pubmed: 32375565
Fertil Steril. 2004 Sep;82(3):559-63
pubmed: 15374695
ILAR J. 2021 Sep 24;60(3):347-365
pubmed: 31608362
Nature. 2002 Nov 21;420(6913):255
pubmed: 12447402
PLoS Biol. 2012;10(11):e1001418
pubmed: 23152719
Curr Protoc Stem Cell Biol. 2007 Jun;Appendix 1:Appendix 1A
pubmed: 18785155
BMC Med Ethics. 2020 Mar 23;21(1):24
pubmed: 32293411