Prediction of all-cause mortality for chronic kidney disease patients using four models of machine learning.
Bayesian network
artificial intelligence
chronic kidney disease
clinical prediction
mortality risk
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
ISSN: 1460-2385
Titre abrégé: Nephrol Dial Transplant
Pays: England
ID NLM: 8706402
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
01
07
2022
medline:
3
7
2023
pubmed:
10
12
2022
entrez:
9
12
2022
Statut:
ppublish
Résumé
The prediction tools developed from general population data to predict all-cause mortality are not adapted to chronic kidney disease (CKD) patients, because this population displays a higher mortality risk. This study aimed to create a clinical prediction tool with good predictive performance to predict the 2-year all-cause mortality of stage 4 or stage 5 CKD patients. The performance of four different models (deep learning, random forest, Bayesian network, logistic regression) to create four prediction tools was compared using a 10-fold cross validation. The model that offered the best performance for predicting mortality in the Photo-Graphe 3 cohort was selected and then optimized using synthetic data and a selected number of explanatory variables. The performance of the optimized prediction tool to correctly predict the 2-year mortality of the patients included in the Photo-Graphe 3 database were then assessed. Prediction tools developed using the Bayesian network and logistic regression tended to have the best performances. Although not significantly different from logistic regression, the prediction tool developed using the Bayesian network was chosen because of its advantages and then optimized. The optimized prediction tool that was developed using synthetic data and the seven variables with the best predictive value (age, erythropoietin-stimulating agent, cardiovascular history, smoking status, 25-hydroxy vitamin D, parathyroid hormone and ferritin levels) had satisfactory internal performance. A Bayesian network was used to create a seven-variable prediction tool to predict the 2-year all-cause mortality in patients with stage 4-5 CKD. Prior to external validation, the proposed prediction tool can be used at: https://dev.hed.cc/?a=jpfauvel&n=2022-05%20Modele%20Bayesien%2020000%20Mortalite%207%20variables%20Naif%20Zou%20online(1).neta for research purposes.
Sections du résumé
BACKGROUND
BACKGROUND
The prediction tools developed from general population data to predict all-cause mortality are not adapted to chronic kidney disease (CKD) patients, because this population displays a higher mortality risk. This study aimed to create a clinical prediction tool with good predictive performance to predict the 2-year all-cause mortality of stage 4 or stage 5 CKD patients.
METHODS
METHODS
The performance of four different models (deep learning, random forest, Bayesian network, logistic regression) to create four prediction tools was compared using a 10-fold cross validation. The model that offered the best performance for predicting mortality in the Photo-Graphe 3 cohort was selected and then optimized using synthetic data and a selected number of explanatory variables. The performance of the optimized prediction tool to correctly predict the 2-year mortality of the patients included in the Photo-Graphe 3 database were then assessed.
RESULTS
RESULTS
Prediction tools developed using the Bayesian network and logistic regression tended to have the best performances. Although not significantly different from logistic regression, the prediction tool developed using the Bayesian network was chosen because of its advantages and then optimized. The optimized prediction tool that was developed using synthetic data and the seven variables with the best predictive value (age, erythropoietin-stimulating agent, cardiovascular history, smoking status, 25-hydroxy vitamin D, parathyroid hormone and ferritin levels) had satisfactory internal performance.
CONCLUSIONS
CONCLUSIONS
A Bayesian network was used to create a seven-variable prediction tool to predict the 2-year all-cause mortality in patients with stage 4-5 CKD. Prior to external validation, the proposed prediction tool can be used at: https://dev.hed.cc/?a=jpfauvel&n=2022-05%20Modele%20Bayesien%2020000%20Mortalite%207%20variables%20Naif%20Zou%20online(1).neta for research purposes.
Identifiants
pubmed: 36484698
pii: 6885460
doi: 10.1093/ndt/gfac316
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1691-1699Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.