The course of attention-deficit/hyperactivity disorder through midlife.
Adults
Attention-Deficit/Hyperactivity Disorder
Clinical follow-up
PRS
Trajectories
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
09 Dec 2022
09 Dec 2022
Historique:
received:
22
07
2022
accepted:
29
11
2022
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
10
12
2022
Statut:
aheadofprint
Résumé
The course of ADHD from childhood up to young adulthood has been characterized in several studies. However, little is known about the course of symptoms into middle age and beyond. This study aims to evaluate predictors of ADHD trajectories in midlife based on three assessments. The follow-up sample comprised 323 adults with ADHD, evaluated at baseline and seven and thirteen years later, from the average ages of 34 up to 47 years old. ADHD status at reassessments was used to characterize trajectories. Demographics, ADHD features, comorbidities, and polygenic scores for ADHD and genetically correlated psychiatric disorders were evaluated to predict ADHD trajectories. Study retention rate was 67% at T2 (n = 216) and 62% at T3 (n = 199). Data from patients evaluated three times showed that 68.8% coursed stable, 25.5% unstable, and 5.7% remission trajectory of ADHD. Women, individuals with more severe syndromes, higher frequency of comorbidities at reassessments, and genetic liability to depression present a higher probability of a stable trajectory. Our findings shed light on midlife ADHD trajectories and their gender, genomic and clinical correlates.
Identifiants
pubmed: 36484846
doi: 10.1007/s00406-022-01531-4
pii: 10.1007/s00406-022-01531-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 476529/2012-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 466722/2014-1
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 424041/2016-2
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 426905/2016-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 431472/2018-1
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : Finance Code 001
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : FIPE-HCPA 160600
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : PqG-19/2551-0001731-6
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 19/2551-001668-9
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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