Acute and chronic blood serum proteome changes in patients with methanol poisoning.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 12 2022
09 12 2022
Historique:
received:
25
08
2022
accepted:
30
11
2022
entrez:
9
12
2022
pubmed:
10
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with group M) and with a control group (C) of 24 samples of patients with a similar proportion of chronic alcohol abuse. When comparing any two groups, tens to hundreds of proteins with a significant change in concentration were identified. Fifteen proteins showed significant changes when compared between any two groups. The group with acute methanol poisoning showed significant changes in protein concentrations for at least 64 proteins compared to the other groups. Among the most important identified proteins closely related to intoxication are mainly those involved in blood coagulation, metabolism of vitamin A (increased retinol-binding protein), immune response (e.g., increased complement factor I, complement factors C3 and C5), and lipid transport (increased apolipoprotein A I, apolipoprotein A II, adiponectin). For blood coagulation, the most affected proteins with significant changes in the methanol poisoning group were von Willebrand factor, carboxypeptidase N, alpha-2-antiplasmin (all increased), inter-alpha-trypsin inhibitor heavy chain H4, kininogen-1, plasma serine protease inhibitor, plasminogen (all decreased). However, heparin administration used for the methanol poisoning group could have interfered with some of the changes in their concentrations. Data are available via ProteomeXchange with the identifier PXD035726.
Identifiants
pubmed: 36494437
doi: 10.1038/s41598-022-25492-9
pii: 10.1038/s41598-022-25492-9
pmc: PMC9734099
doi:
Substances chimiques
Methanol
Y4S76JWI15
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21379Informations de copyright
© 2022. The Author(s).
Références
Br J Pharmacol. 2001 Aug;133(8):1323-9
pubmed: 11498518
Biochem J. 1987 Apr 15;243(2):579-88
pubmed: 2443128
Arterioscler Thromb Vasc Biol. 1997 May;17(5):925-31
pubmed: 9157957
J Cell Biochem. 1999 Jun 1;73(3):303-11
pubmed: 10321830
Nucleic Acids Res. 2021 Jan 8;49(D1):D613-D621
pubmed: 33211851
Toxicol Appl Pharmacol. 2013 Feb 1;266(3):470-80
pubmed: 23200777
Biochem Med. 1975 Aug;13(4):319-33
pubmed: 2163
Clin Toxicol (Phila). 2021 Mar;59(3):235-245
pubmed: 32762574
J Biol Chem. 1992 Nov 15;267(32):23035-42
pubmed: 1331074
Wien Klin Wochenschr. 2017 Nov;129(21-22):835-843
pubmed: 28762059
Neuropharmacology. 2015 Aug;95:309-20
pubmed: 25839897
Clin Toxicol (Phila). 2018 Oct;56(10):893-903
pubmed: 29607701
Diabetes. 2021 Mar;70(3):788-799
pubmed: 33334874
Cell Biol Toxicol. 2007 May;23(3):177-87
pubmed: 17131096
J Mass Spectrom. 2015 Nov;50(11):1270-8
pubmed: 26505772
Scand J Clin Lab Invest. 1968;21(1):89-91
pubmed: 5637480
Neuro Endocrinol Lett. 2015;36(8):737-44
pubmed: 26921573
Methods Mol Biol. 2010;604:55-71
pubmed: 20013364
N Engl J Med. 1982 Sep 2;307(10):597-601
pubmed: 7202119
PLoS One. 2013 Jun 20;8(6):e66649
pubmed: 23818956
Biochem J. 1989 Jan 1;257(1):143-50
pubmed: 2920007
Ann Neurol. 2000 Jan;47(1):54-63
pubmed: 10632101
Blood Rev. 2015 Jul;29(4):231-41
pubmed: 25555324
J Biol Chem. 2002 Jun 21;277(25):22553-7
pubmed: 11960985
Immunol Cell Biol. 2010 Nov-Dec;88(8):781-6
pubmed: 20404838
Clin Toxicol (Phila). 2007;45(2):152-7
pubmed: 17364632
Clin J Am Soc Nephrol. 2008 Jan;3(1):208-25
pubmed: 18045860
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Front Cell Neurosci. 2020 Nov 19;14:577935
pubmed: 33328889
Proteomics Clin Appl. 2008 Jul;2(7-8):1087-98
pubmed: 21136906
Res Exp Med (Berl). 1988;188(3):175-81
pubmed: 3420300
J Neurosci. 2018 Mar 7;38(10):2519-2532
pubmed: 29437855
Front Physiol. 2018 Aug 30;9:1215
pubmed: 30214418
J Am Coll Cardiol. 2000 Jul;36(1):110-4
pubmed: 10898421
Am Heart J. 2000 Apr;139(4):704-9
pubmed: 10740155
Toxicol Mech Methods. 2003;13(4):277-93
pubmed: 20021153
Sci Transl Med. 2019 Jul 3;11(499):
pubmed: 31270273
Front Cell Neurosci. 2014 Nov 07;8:380
pubmed: 25426028
Nat Protoc. 2007;2(8):1896-906
pubmed: 17703201
J Intern Med. 2005 Aug;258(2):181-90
pubmed: 16018795
FASEB J. 2013 Sep;27(9):3797-804
pubmed: 23737250
Alcohol Clin Exp Res. 1979 Apr;3(2):135-41
pubmed: 391074
Gastroenterology. 1983 Mar;84(3):562-72
pubmed: 6681606
Circulation. 2001 Sep 18;104(12):1367-73
pubmed: 11560851
Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2636-2639
pubmed: 15800867
EMBO J. 2006 Mar 22;25(6):1364-74
pubmed: 16498410
Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G732-45
pubmed: 20150243
J Anal Toxicol. 2020 Dec 12;44(8):880-885
pubmed: 32364609
J Neurosci. 2015 Jan 14;35(2):518-26
pubmed: 25589747
Nutrients. 2012 May;4(5):356-71
pubmed: 22690322
Chem Biol Interact. 2006 May 15;161(1):14-25
pubmed: 16564515
J Crit Care. 2017 Jun;39:190-198
pubmed: 28291652
Thromb Haemost. 1998 Mar;79(3):587-90
pubmed: 9531046
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
Med Princ Pract. 2015;24(6):581-3
pubmed: 26380973
J Proteome Res. 2008 Feb;7(2):731-40
pubmed: 18183947
J Neuroinflammation. 2018 Jan 22;15(1):24
pubmed: 29357880
Lancet. 1975 May 31;1(7918):1251-2
pubmed: 48886
Clin Toxicol (Phila). 2014 Dec;52(10):1013-24
pubmed: 25345388
Genome Biol. 2016 May 06;17(1):91
pubmed: 27154141
Arch Toxicol. 2022 Feb;96(2):431-451
pubmed: 34988610
Hepatology. 1991 Nov;14(5):776-80
pubmed: 1657753
Clin Toxicol (Phila). 2015;53(8):797-806
pubmed: 26109326
Am J Ophthalmol. 2018 Jul;191:100-115
pubmed: 29709459
Cent Eur J Public Health. 2019 Dec;27 Suppl:S29-S39
pubmed: 31901190
Rapid Commun Mass Spectrom. 2018 Jun 15;32(11):871-881
pubmed: 29520858
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
Prog Retin Eye Res. 2004 Jan;23(1):53-89
pubmed: 14766317
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
J Hepatol. 1989 Jan;8(1):26-31
pubmed: 2921501
J Mol Neurosci. 2018 Jul;65(3):277-288
pubmed: 29915983
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
J Sep Sci. 2021 Nov;44(22):4132-4140
pubmed: 34545700
Chem Res Toxicol. 2017 Aug 21;30(8):1592-1598
pubmed: 28662331
Atherosclerosis. 1995 Jun;115(2):225-32
pubmed: 7661881
Turk J Anaesthesiol Reanim. 2015 Oct;43(5):337-43
pubmed: 27366524
Int J Vitam Nutr Res. 1983;53(3):273-9
pubmed: 6629666
Thromb Haemost. 1988 Dec 22;60(3):457-62
pubmed: 3238649
Toxicology. 2012 Mar 11;293(1-3):89-96
pubmed: 22257634
Neuroreport. 2001 Feb 12;12(2):289-93
pubmed: 11209937
Clin Toxicol (Phila). 2020 Apr;58(4):241-253
pubmed: 31298045
Toxicol Lett. 2018 Dec 1;298:60-69
pubmed: 29733875
Arch Intern Med. 2003 Oct 27;163(19):2368-92
pubmed: 14581258
Mol Cell Proteomics. 2014 Jan;13(1):339-47
pubmed: 24143002
Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):228-38
pubmed: 26806851