A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud.
Antioxydant
Antiviral
COVID-19
Paulownia tomentosa Steud extract
Phytocomplex
SARS-CoV-2
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
14
09
2022
revised:
23
11
2022
accepted:
02
12
2022
pubmed:
11
12
2022
medline:
19
1
2023
entrez:
10
12
2022
Statut:
ppublish
Résumé
COronaVIrus Disease 2019 (COVID-19) is a newly emerging infectious disease that spread across the world, caused by the novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Despite the advancements in science that led to the creation of the vaccine, there is still an urgent need for new antiviral drugs effective against SARS-CoV-2. This study aimed to investigate the antiviral effect of Paulownia tomentosa Steud extract against SARS-CoV-2 and to evaluate its antioxidant properties, including respiratory smooth muscle relaxant effects. Our results showed that P. tomentosa extract can inhibit viral replication by directly interacting with both the 3-chymotrypsin-like protease and spike protein. In addition, the phyto complex does not reduce lung epithelial cell viability and exerts a protective action in those cells damaged by tert-butyl hydroperoxide , a toxic agent able to alter cells' functions via increased oxidative stress. These data suggest the potential role of P. tomentosa extract in COVID-19 treatment, since this extract is able to act both as an antiviral and a cytoprotective agent in vitro.
Identifiants
pubmed: 36495668
pii: S0753-3322(22)01472-X
doi: 10.1016/j.biopha.2022.114083
pmc: PMC9721285
pii:
doi:
Substances chimiques
Antiviral Agents
0
Antioxidants
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114083Informations de copyright
Copyright © 2022. Published by Elsevier Masson SAS.
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