Synthesis and pharmacokinetic properties of novel cPLA
Bioavailability
Caco2 cell permeation
Cytosolic phospholipase A(2)α
Inhibitor
Metabolic stability
Solubility
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
07
10
2022
revised:
16
11
2022
accepted:
22
11
2022
pubmed:
11
12
2022
medline:
4
1
2023
entrez:
10
12
2022
Statut:
ppublish
Résumé
Indole-5-carboxylic acids with 3-aryloxy-2‑oxopropyl residues in position 1 have been shown to be potent inhibitors of cytosolic phospholipase A
Identifiants
pubmed: 36495814
pii: S0968-0896(22)00503-X
doi: 10.1016/j.bmc.2022.117110
pii:
doi:
Substances chimiques
Group IV Phospholipases A2
EC 3.1.1.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117110Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.