Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors.
Cancer
Cda-knockout mice
Cytidine deaminase (Cda)
Genetic instability
Poly(ADP-Ribose) polymerase 1(Parp-1)
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
received:
29
08
2022
revised:
22
11
2022
accepted:
29
11
2022
pubmed:
11
12
2022
medline:
25
1
2023
entrez:
10
12
2022
Statut:
ppublish
Résumé
Cytidine deaminase (CDA) catalyzes the deamination of cytidine (C) and deoxycytidine (dC) to uridine and deoxyuridine, respectively. We recently showed that CDA deficiency leads to genomic instability, a hallmark of cancers. We therefore investigated whether constitutive CDA inactivation conferred a predisposition to cancer development. We developed a novel mouse model of Cda deficiency by generating Cda-knockout mice. Cda
Identifiants
pubmed: 36496104
pii: S0304-3835(22)00517-1
doi: 10.1016/j.canlet.2022.216030
pii:
doi:
Substances chimiques
Cytidine Deaminase
EC 3.5.4.5
Poly(ADP-ribose) Polymerase Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
216030Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.