Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types.
ROH
autozygosity
inbreeding
microarray
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
25 Nov 2022
25 Nov 2022
Historique:
received:
28
09
2022
revised:
18
11
2022
accepted:
22
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
12
12
2022
Statut:
epublish
Résumé
The present study reports runs of homozygosity (ROH) distribution in the genomes of six horse breeds (571 horses in total) representing three horse types (primitive, light, and draft horses) based on the 65k Equine BeadChip assay. Of major interest was the length, quantity, and frequency of ROH characteristics, as well as differences between horse breeds and types. Noticeable differences in the number, length and distribution of ROH between breeds were observed, as well as in genomic inbreeding coefficients. We also identified regions of the genome characterized by high ROH coverage, known as ROH islands, which may be signals of recent selection events. Eight to fourteen ROH islands were identified per breed, which spanned multiple genes. Many were involved in important horse breed characteristics, including
Identifiants
pubmed: 36496815
pii: ani12233293
doi: 10.3390/ani12233293
pmc: PMC9736150
pii:
doi:
Types de publication
Journal Article
Langues
eng
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